ALPI (alkaline phosphatase, intestinal)

2003-11-01 Affiliation

Identity

HGNC

ALPI

LOCATION

2q37.1

LOCUSID

248

ALIAS

IAP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 248
MIM: 171740
HGNC: 437
Ensembl: ENSG00000163295

Variants:

dbSNP: 248
ClinVar: 248
TCGA: ENSG00000163295
COSMIC: ALPI

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163295	ENST00000295463	P09923
ENSG00000163295	ENST00000295463	A0A024R4A2
ENSG00000163295	ENST00000457560	F8WEQ0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Thiamine metabolism	KEGG	ko00730
Folate biosynthesis	KEGG	ko00790
Thiamine metabolism	KEGG	hsa00730
Folate biosynthesis	KEGG	hsa00790
Metabolic pathways	KEGG	hsa01100
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteins	REACTOME	R-HSA-163125
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Synthesis of PA	REACTOME	R-HSA-1483166
Miscellaneous digestion events	REACTOME	R-HSA-8935690

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18292227	2008	Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition.	111
12919939	2004	Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor.	38
20489044	2010	Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase.	37
12372831	2002	Structural evidence of functional divergence in human alkaline phosphatases.	27
27083970	2016	Intestinal alkaline phosphatase: a summary of its role in clinical disease.	19
27106638	2016	Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.	19
22783049	2012	Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease.	14
26299896	2015	Optimization of Caco-2 and HT29 co-culture in vitro cell models for permeability studies.	12
15831710	2005	Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells.	11
25037223	2014	The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.	10

Citation

Dessen P

ALPI (alkaline phosphatase, intestinal)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/622/alpi