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ALPK1 (alpha-kinase 1)

Identity

Alias_symbol (synonym)Lak
FLJ22670
KIAA1527
Other alias8430410J10Rik
LAK
HGNC (Hugo) ALPK1
LocusID (NCBI) 80216
Atlas_Id 60265
Location 4q25  [Link to chromosome band 4q25]
Location_base_pair Starts at 113218499 and ends at 113363764 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ALPK1 (4q25) / ELP2 (18q12.2)ANK2 (4q25) / ALPK1 (4q25)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALPK1   20917
Cards
Entrez_Gene (NCBI)ALPK1  80216  alpha-kinase 1
Aliases8430410J10Rik; LAK
GeneCards (Weizmann)ALPK1
Ensembl hg19 (Hinxton)ENSG00000073331 [Gene_View]  chr4:113218499-113363764 [Contig_View]  ALPK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000073331 [Gene_View]  chr4:113218499-113363764 [Contig_View]  ALPK1 [Vega]
ICGC DataPortalENSG00000073331
TCGA cBioPortalALPK1
AceView (NCBI)ALPK1
Genatlas (Paris)ALPK1
WikiGenes80216
SOURCE (Princeton)ALPK1
Genetics Home Reference (NIH)ALPK1
Genomic and cartography
GoldenPath hg19 (UCSC)ALPK1  -     chr4:113218499-113363764 +  4q25   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALPK1  -     4q25   [Description]    (hg38-Dec_2013)
EnsemblALPK1 - 4q25 [CytoView hg19]  ALPK1 - 4q25 [CytoView hg38]
Mapping of homologs : NCBIALPK1 [Mapview hg19]  ALPK1 [Mapview hg38]
OMIM607347   
Gene and transcription
Genbank (Entrez)AB040960 AB075877 AK026323 AK026715 AK091872
RefSeq transcript (Entrez)NM_001102406 NM_001253884 NM_025144
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)ALPK1
Cluster EST : UnigeneHs.652825 [ NCBI ]
CGAP (NCI)Hs.652825
Alternative Splicing GalleryENSG00000073331
Gene ExpressionALPK1 [ NCBI-GEO ]   ALPK1 [ EBI - ARRAY_EXPRESS ]   ALPK1 [ SEEK ]   ALPK1 [ MEM ]
Gene Expression Viewer (FireBrowse)ALPK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80216
GTEX Portal (Tissue expression)ALPK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96QP1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96QP1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96QP1
Splice isoforms : SwissVarQ96QP1
Catalytic activity : Enzyme2.7.11.- [ Enzyme-Expasy ]   2.7.11.-2.7.11.- [ IntEnz-EBI ]   2.7.11.- [ BRENDA ]   2.7.11.- [ KEGG ]   
PhosPhoSitePlusQ96QP1
Domaine pattern : Prosite (Expaxy)ALPHA_KINASE (PS51158)   
Domains : Interpro (EBI)Kinase-like_dom    MHCK_EF2_kinase   
Domain families : Pfam (Sanger)Alpha_kinase (PF02816)   
Domain families : Pfam (NCBI)pfam02816   
Domain families : Smart (EMBL)Alpha_kinase (SM00811)  
Conserved Domain (NCBI)ALPK1
DMDM Disease mutations80216
Blocks (Seattle)ALPK1
SuperfamilyQ96QP1
Human Protein AtlasENSG00000073331
Peptide AtlasQ96QP1
HPRD09554
IPIIPI00304706   IPI00018624   IPI00963820   IPI00968036   IPI00910947   IPI00967449   IPI00967754   
Protein Interaction databases
DIP (DOE-UCLA)Q96QP1
IntAct (EBI)Q96QP1
FunCoupENSG00000073331
BioGRIDALPK1
STRING (EMBL)ALPK1
ZODIACALPK1
Ontologies - Pathways
QuickGOQ96QP1
Ontology : AmiGOpositive regulation of defense response to virus by host  protein serine/threonine kinase activity  ATP binding  protein phosphorylation  activation of mitophagy in response to mitochondrial depolarization  
Ontology : EGO-EBIpositive regulation of defense response to virus by host  protein serine/threonine kinase activity  ATP binding  protein phosphorylation  activation of mitophagy in response to mitochondrial depolarization  
NDEx NetworkALPK1
Atlas of Cancer Signalling NetworkALPK1
Wikipedia pathwaysALPK1
Orthology - Evolution
OrthoDB80216
GeneTree (enSembl)ENSG00000073331
Phylogenetic Trees/Animal Genes : TreeFamALPK1
HOVERGENQ96QP1
HOGENOMQ96QP1
Homologs : HomoloGeneALPK1
Homology/Alignments : Family Browser (UCSC)ALPK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALPK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALPK1
dbVarALPK1
ClinVarALPK1
1000_GenomesALPK1 
Exome Variant ServerALPK1
ExAC (Exome Aggregation Consortium)ALPK1 (select the gene name)
Genetic variants : HAPMAP80216
Genomic Variants (DGV)ALPK1 [DGVbeta]
DECIPHER (Syndromes)4:113218499-113363764  ENSG00000073331
CONAN: Copy Number AnalysisALPK1 
Mutations
ICGC Data PortalALPK1 
TCGA Data PortalALPK1 
Broad Tumor PortalALPK1
OASIS PortalALPK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALPK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALPK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALPK1
DgiDB (Drug Gene Interaction Database)ALPK1
DoCM (Curated mutations)ALPK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALPK1 (select a term)
intoGenALPK1
Cancer3DALPK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607347   
Orphanet
MedgenALPK1
Genetic Testing Registry ALPK1
NextProtQ96QP1 [Medical]
TSGene80216
GENETestsALPK1
Huge Navigator ALPK1 [HugePedia]
snp3D : Map Gene to Disease80216
BioCentury BCIQALPK1
ClinGenALPK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80216
Chemical/Pharm GKB GenePA134891785
Clinical trialALPK1
Miscellaneous
canSAR (ICR)ALPK1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALPK1
EVEXALPK1
GoPubMedALPK1
iHOPALPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 11:54:09 CET 2017

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