Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ALPL (alkaline phosphatase, liver/bone/kidney)

Identity

Alias_namesHOPS
Alias_symbol (synonym)TNSALP
Other aliasAP-TNAP
APTNAP
TNAP
HGNC (Hugo) ALPL
LocusID (NCBI) 249
Atlas_Id 623
Location 1p36.12  [Link to chromosome band 1p36]
Location_base_pair Starts at 21509358 and ends at 21578412 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ALPL (1p36.12) / CBLB (3q13.11)ALPL (1p36.12) / FILIP1L (3q12.1)CD302 (2q24.2) / ALPL (1p36.12)
ALPL 1p36.12 / FILIP1L 3q12.1CD302 2q24.2 / ALPL 1p36.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALPL   438
Cards
Entrez_Gene (NCBI)ALPL  249  alkaline phosphatase, liver/bone/kidney
AliasesAP-TNAP; APTNAP; HOPS; TNAP; 
TNSALP
GeneCards (Weizmann)ALPL
Ensembl hg19 (Hinxton)ENSG00000162551 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162551 [Gene_View]  chr1:21509358-21578412 [Contig_View]  ALPL [Vega]
ICGC DataPortalENSG00000162551
TCGA cBioPortalALPL
AceView (NCBI)ALPL
Genatlas (Paris)ALPL
WikiGenes249
SOURCE (Princeton)ALPL
Genetics Home Reference (NIH)ALPL
Genomic and cartography
GoldenPath hg38 (UCSC)ALPL  -     chr1:21509358-21578412 +  1p36.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALPL  -     1p36.12   [Description]    (hg19-Feb_2009)
EnsemblALPL - 1p36.12 [CytoView hg19]  ALPL - 1p36.12 [CytoView hg38]
Mapping of homologs : NCBIALPL [Mapview hg19]  ALPL [Mapview hg38]
OMIM146300   171760   241500   241510   
Gene and transcription
Genbank (Entrez)AB011406 AB012643 AB209814 AH007388 AK097413
RefSeq transcript (Entrez)NM_000478 NM_001127501 NM_001177520
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALPL
Cluster EST : UnigeneHs.75431 [ NCBI ]
CGAP (NCI)Hs.75431
Alternative Splicing GalleryENSG00000162551
Gene ExpressionALPL [ NCBI-GEO ]   ALPL [ EBI - ARRAY_EXPRESS ]   ALPL [ SEEK ]   ALPL [ MEM ]
Gene Expression Viewer (FireBrowse)ALPL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)249
GTEX Portal (Tissue expression)ALPL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05186   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05186  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05186
Splice isoforms : SwissVarP05186
PhosPhoSitePlusP05186
Domaine pattern : Prosite (Expaxy)ALKALINE_PHOSPHATASE (PS00123)   
Domains : Interpro (EBI)Alkaline_Pase-like_a/b/a    Alkaline_phosphatase    Alkaline_phosphatase_AS    Alkaline_phosphatase_core   
Domain families : Pfam (Sanger)Alk_phosphatase (PF00245)   
Domain families : Pfam (NCBI)pfam00245   
Domain families : Smart (EMBL)alkPPc (SM00098)  
Conserved Domain (NCBI)ALPL
DMDM Disease mutations249
Blocks (Seattle)ALPL
SuperfamilyP05186
Human Protein AtlasENSG00000162551
Peptide AtlasP05186
HPRD01377
IPIIPI00419916   IPI00956631   IPI00643764   
Protein Interaction databases
DIP (DOE-UCLA)P05186
IntAct (EBI)P05186
FunCoupENSG00000162551
BioGRIDALPL
STRING (EMBL)ALPL
ZODIACALPL
Ontologies - Pathways
QuickGOP05186
Ontology : AmiGOskeletal system development  osteoblast differentiation  endochondral ossification  developmental process involved in reproduction  alkaline phosphatase activity  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  plasma membrane  C-terminal protein lipidation  membrane  integral component of membrane  dephosphorylation  pyrophosphatase activity  anchored component of membrane  response to lipopolysaccharide  response to vitamin D  response to antibiotic  metal ion binding  response to glucocorticoid  extracellular membrane-bounded organelle  extracellular exosome  cellular response to organic cyclic compound  cementum mineralization  
Ontology : EGO-EBIskeletal system development  osteoblast differentiation  endochondral ossification  developmental process involved in reproduction  alkaline phosphatase activity  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  plasma membrane  C-terminal protein lipidation  membrane  integral component of membrane  dephosphorylation  pyrophosphatase activity  anchored component of membrane  response to lipopolysaccharide  response to vitamin D  response to antibiotic  metal ion binding  response to glucocorticoid  extracellular membrane-bounded organelle  extracellular exosome  cellular response to organic cyclic compound  cementum mineralization  
Pathways : BIOCARTARegulators of Bone Mineralization [Genes]   
Pathways : KEGGFolate biosynthesis   
NDEx NetworkALPL
Atlas of Cancer Signalling NetworkALPL
Wikipedia pathwaysALPL
Orthology - Evolution
OrthoDB249
GeneTree (enSembl)ENSG00000162551
Phylogenetic Trees/Animal Genes : TreeFamALPL
HOVERGENP05186
HOGENOMP05186
Homologs : HomoloGeneALPL
Homology/Alignments : Family Browser (UCSC)ALPL
Gene fusions - Rearrangements
Fusion : MitelmanALPL/FILIP1L [1p36.12/3q12.1]  
Fusion : MitelmanCD302/ALPL [2q24.2/1p36.12]  [t(1;2)(p36;q24)]  
Fusion: TCGAALPL 1p36.12 FILIP1L 3q12.1 BRCA
Fusion: TCGACD302 2q24.2 ALPL 1p36.12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALPL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALPL
dbVarALPL
ClinVarALPL
1000_GenomesALPL 
Exome Variant ServerALPL
ExAC (Exome Aggregation Consortium)ALPL (select the gene name)
Genetic variants : HAPMAP249
Genomic Variants (DGV)ALPL [DGVbeta]
DECIPHERALPL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALPL 
Mutations
ICGC Data PortalALPL 
TCGA Data PortalALPL 
Broad Tumor PortalALPL
OASIS PortalALPL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALPL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALPL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALPL
DgiDB (Drug Gene Interaction Database)ALPL
DoCM (Curated mutations)ALPL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALPL (select a term)
intoGenALPL
Cancer3DALPL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146300    171760    241500    241510   
Orphanet19536    19531    19532    19533    19534    19535   
MedgenALPL
Genetic Testing Registry ALPL
NextProtP05186 [Medical]
TSGene249
GENETestsALPL
Target ValidationALPL
Huge Navigator ALPL [HugePedia]
snp3D : Map Gene to Disease249
BioCentury BCIQALPL
ClinGenALPL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD249
Chemical/Pharm GKB GenePA24729
Clinical trialALPL
Miscellaneous
canSAR (ICR)ALPL (select the gene name)
Probes
Litterature
PubMed218 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALPL
EVEXALPL
GoPubMedALPL
iHOPALPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:23:32 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.