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ALPP (alkaline phosphatase, placental)

Identity

Alias_namesalkaline phosphatase
Other aliasALP
PALP
PLAP
PLAP-1
HGNC (Hugo) ALPP
LocusID (NCBI) 250
Atlas_Id 50534
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 232378534 and ends at 232382889 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ALPP (2q37.1) / PTPRU (1p35.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALPP   439
Cards
Entrez_Gene (NCBI)ALPP  250  alkaline phosphatase, placental
AliasesALP; PALP; PLAP; PLAP-1
GeneCards (Weizmann)ALPP
Ensembl hg19 (Hinxton)ENSG00000163283 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163283 [Gene_View]  chr2:232378534-232382889 [Contig_View]  ALPP [Vega]
ICGC DataPortalENSG00000163283
TCGA cBioPortalALPP
AceView (NCBI)ALPP
Genatlas (Paris)ALPP
WikiGenes250
SOURCE (Princeton)ALPP
Genetics Home Reference (NIH)ALPP
Genomic and cartography
GoldenPath hg38 (UCSC)ALPP  -     chr2:232378534-232382889 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALPP  -     2q37.1   [Description]    (hg19-Feb_2009)
EnsemblALPP - 2q37.1 [CytoView hg19]  ALPP - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIALPP [Mapview hg19]  ALPP [Mapview hg38]
OMIM171800   
Gene and transcription
Genbank (Entrez)AF217992 AH007074 AK075432 AK312931 BC009647
RefSeq transcript (Entrez)NM_001632
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALPP
Cluster EST : UnigeneHs.284255 [ NCBI ]
CGAP (NCI)Hs.284255
Alternative Splicing GalleryENSG00000163283
Gene ExpressionALPP [ NCBI-GEO ]   ALPP [ EBI - ARRAY_EXPRESS ]   ALPP [ SEEK ]   ALPP [ MEM ]
Gene Expression Viewer (FireBrowse)ALPP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)250
GTEX Portal (Tissue expression)ALPP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05187   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05187  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05187
Splice isoforms : SwissVarP05187
Catalytic activity : Enzyme3.1.3.1 [ Enzyme-Expasy ]   3.1.3.13.1.3.1 [ IntEnz-EBI ]   3.1.3.1 [ BRENDA ]   3.1.3.1 [ KEGG ]   
PhosPhoSitePlusP05187
Domaine pattern : Prosite (Expaxy)ALKALINE_PHOSPHATASE (PS00123)   
Domains : Interpro (EBI)Alkaline_Pase-like_a/b/a    Alkaline_phosphatase    Alkaline_phosphatase_AS    Alkaline_phosphatase_core   
Domain families : Pfam (Sanger)Alk_phosphatase (PF00245)   
Domain families : Pfam (NCBI)pfam00245   
Domain families : Smart (EMBL)alkPPc (SM00098)  
Conserved Domain (NCBI)ALPP
DMDM Disease mutations250
Blocks (Seattle)ALPP
PDB (SRS)1EW2    1ZEB    1ZED    1ZEF    2GLQ    3MK0    3MK1    3MK2   
PDB (PDBSum)1EW2    1ZEB    1ZED    1ZEF    2GLQ    3MK0    3MK1    3MK2   
PDB (IMB)1EW2    1ZEB    1ZED    1ZEF    2GLQ    3MK0    3MK1    3MK2   
PDB (RSDB)1EW2    1ZEB    1ZED    1ZEF    2GLQ    3MK0    3MK1    3MK2   
Structural Biology KnowledgeBase1EW2    1ZEB    1ZED    1ZEF    2GLQ    3MK0    3MK1    3MK2   
SCOP (Structural Classification of Proteins)1EW2    1ZEB    1ZED    1ZEF    2GLQ    3MK0    3MK1    3MK2   
CATH (Classification of proteins structures)1EW2    1ZEB    1ZED    1ZEF    2GLQ    3MK0    3MK1    3MK2   
SuperfamilyP05187
Human Protein AtlasENSG00000163283
Peptide AtlasP05187
IPIIPI00007289   
Protein Interaction databases
DIP (DOE-UCLA)P05187
IntAct (EBI)P05187
FunCoupENSG00000163283
BioGRIDALPP
STRING (EMBL)ALPP
ZODIACALPP
Ontologies - Pathways
QuickGOP05187
Ontology : AmiGOmagnesium ion binding  alkaline phosphatase activity  alkaline phosphatase activity  protein binding  plasma membrane  zinc ion binding  cell surface  integral component of membrane  dephosphorylation  anchored component of membrane  
Ontology : EGO-EBImagnesium ion binding  alkaline phosphatase activity  alkaline phosphatase activity  protein binding  plasma membrane  zinc ion binding  cell surface  integral component of membrane  dephosphorylation  anchored component of membrane  
Pathways : KEGGFolate biosynthesis   
NDEx NetworkALPP
Atlas of Cancer Signalling NetworkALPP
Wikipedia pathwaysALPP
Orthology - Evolution
OrthoDB250
GeneTree (enSembl)ENSG00000163283
Phylogenetic Trees/Animal Genes : TreeFamALPP
HOVERGENP05187
HOGENOMP05187
Homologs : HomoloGeneALPP
Homology/Alignments : Family Browser (UCSC)ALPP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALPP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALPP
dbVarALPP
ClinVarALPP
1000_GenomesALPP 
Exome Variant ServerALPP
ExAC (Exome Aggregation Consortium)ALPP (select the gene name)
Genetic variants : HAPMAP250
Genomic Variants (DGV)ALPP [DGVbeta]
DECIPHERALPP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALPP 
Mutations
ICGC Data PortalALPP 
TCGA Data PortalALPP 
Broad Tumor PortalALPP
OASIS PortalALPP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALPP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALPP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALPP
DgiDB (Drug Gene Interaction Database)ALPP
DoCM (Curated mutations)ALPP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALPP (select a term)
intoGenALPP
Cancer3DALPP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM171800   
Orphanet
MedgenALPP
Genetic Testing Registry ALPP
NextProtP05187 [Medical]
TSGene250
GENETestsALPP
Target ValidationALPP
Huge Navigator ALPP [HugePedia]
snp3D : Map Gene to Disease250
BioCentury BCIQALPP
ClinGenALPP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD250
Chemical/Pharm GKB GenePA24730
Clinical trialALPP
Miscellaneous
canSAR (ICR)ALPP (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALPP
EVEXALPP
GoPubMedALPP
iHOPALPP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:23:32 CEST 2017

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