ALPP (alkaline phosphatase, placental)

2008-12-01  

Identity

HGNC
ALPP
LOCATION
2q37.1
LOCUSID
250
ALIAS
ALP,ALPI,IAP,PALP,PLAP,PLAP-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 250
MIM: 171800
HGNC: 439
Ensembl: ENSG00000163283

Variants:

dbSNP: 250
ClinVar: 250
TCGA: ENSG00000163283
COSMIC: ALPP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163283ENST00000392027P05187

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thiamine metabolismKEGGko00730
Folate biosynthesisKEGGko00790
Thiamine metabolismKEGGhsa00730
Folate biosynthesisKEGGhsa00790
Metabolic pathwaysKEGGhsa01100
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
187523242008Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis.88
123728312002Structural evidence of functional divergence in human alkaline phosphatases.27
223331592012High serum alkaline phosphatase cooperating with MMP-9 predicts metastasis and poor prognosis in patients with primary osteosarcoma in Southern China.27
202993382010Outcome predictability of serum alkaline phosphatase in men with pre-dialysis CKD.25
195748832009Diagnostic utility of SALL4 in extragonadal yolk sac tumors: an immunohistochemical study of 59 cases with comparison to placental-like alkaline phosphatase, alpha-fetoprotein, and glypican-3.19
159466772005Structural studies of human placental alkaline phosphatase in complex with functional ligands.13
120814852002Proximity of the protein moiety of a GPI-anchored protein to the membrane surface: a FRET study.10
184165352008Membrane features and activity of GPI-anchored enzymes: alkaline phosphatase reconstituted in model membranes.10
168931772006Mammalian alkaline phosphatase catalysis requires active site structure stabilization via the N-terminal amino acid microenvironment.9
240195142013Identification of a region within the placental alkaline phosphatase mRNA that mediates p180-dependent targeting to the endoplasmic reticulum.9

Citation

Dessen P

ALPP (alkaline phosphatase, placental)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50534/alpp