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ALPPL2 (alkaline phosphatase, placental like 2)

Identity

Alias_namesalkaline phosphatase
Other aliasALPG
ALPPL
GCAP
HGNC (Hugo) ALPPL2
LocusID (NCBI) 251
Atlas_Id 624
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233271552 and ends at 233275424 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Testis: Spermatocytic seminoma


External links

Nomenclature
HGNC (Hugo)ALPPL2   441
Cards
Entrez_Gene (NCBI)ALPPL2  251  alkaline phosphatase, placental like 2
AliasesALPG; ALPPL; GCAP
GeneCards (Weizmann)ALPPL2
Ensembl hg19 (Hinxton)ENSG00000163286 [Gene_View]  chr2:233271552-233275424 [Contig_View]  ALPPL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163286 [Gene_View]  chr2:233271552-233275424 [Contig_View]  ALPPL2 [Vega]
ICGC DataPortalENSG00000163286
TCGA cBioPortalALPPL2
AceView (NCBI)ALPPL2
Genatlas (Paris)ALPPL2
WikiGenes251
SOURCE (Princeton)ALPPL2
Genetics Home Reference (NIH)ALPPL2
Genomic and cartography
GoldenPath hg19 (UCSC)ALPPL2  -     chr2:233271552-233275424 +  2q37.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALPPL2  -     2q37.1   [Description]    (hg38-Dec_2013)
EnsemblALPPL2 - 2q37.1 [CytoView hg19]  ALPPL2 - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIALPPL2 [Mapview hg19]  ALPPL2 [Mapview hg38]
OMIM171810   
Gene and transcription
Genbank (Entrez)AB012642 AI982769 AK293017 BC014139 DB194270
RefSeq transcript (Entrez)NM_031313
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)ALPPL2
Cluster EST : UnigeneHs.333509 [ NCBI ]
CGAP (NCI)Hs.333509
Alternative Splicing GalleryENSG00000163286
Gene ExpressionALPPL2 [ NCBI-GEO ]   ALPPL2 [ EBI - ARRAY_EXPRESS ]   ALPPL2 [ SEEK ]   ALPPL2 [ MEM ]
Gene Expression Viewer (FireBrowse)ALPPL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)251
GTEX Portal (Tissue expression)ALPPL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10696   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10696  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10696
Splice isoforms : SwissVarP10696
Catalytic activity : Enzyme3.1.3.1 [ Enzyme-Expasy ]   3.1.3.13.1.3.1 [ IntEnz-EBI ]   3.1.3.1 [ BRENDA ]   3.1.3.1 [ KEGG ]   
PhosPhoSitePlusP10696
Domaine pattern : Prosite (Expaxy)ALKALINE_PHOSPHATASE (PS00123)   
Domains : Interpro (EBI)Alkaline_Pase-like_a/b/a    Alkaline_phosphatase    Alkaline_phosphatase_AS    Alkaline_phosphatase_core   
Domain families : Pfam (Sanger)Alk_phosphatase (PF00245)   
Domain families : Pfam (NCBI)pfam00245   
Domain families : Smart (EMBL)alkPPc (SM00098)  
Conserved Domain (NCBI)ALPPL2
DMDM Disease mutations251
Blocks (Seattle)ALPPL2
SuperfamilyP10696
Human Protein AtlasENSG00000163286
Peptide AtlasP10696
HPRD01380
IPIIPI00290380   
Protein Interaction databases
DIP (DOE-UCLA)P10696
IntAct (EBI)P10696
FunCoupENSG00000163286
BioGRIDALPPL2
STRING (EMBL)ALPPL2
ZODIACALPPL2
Ontologies - Pathways
QuickGOP10696
Ontology : AmiGOalkaline phosphatase activity  plasma membrane  dephosphorylation  dephosphorylation  anchored component of membrane  metal ion binding  
Ontology : EGO-EBIalkaline phosphatase activity  plasma membrane  dephosphorylation  dephosphorylation  anchored component of membrane  metal ion binding  
Pathways : KEGGFolate biosynthesis   
NDEx NetworkALPPL2
Atlas of Cancer Signalling NetworkALPPL2
Wikipedia pathwaysALPPL2
Orthology - Evolution
OrthoDB251
GeneTree (enSembl)ENSG00000163286
Phylogenetic Trees/Animal Genes : TreeFamALPPL2
HOVERGENP10696
HOGENOMP10696
Homologs : HomoloGeneALPPL2
Homology/Alignments : Family Browser (UCSC)ALPPL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALPPL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALPPL2
dbVarALPPL2
ClinVarALPPL2
1000_GenomesALPPL2 
Exome Variant ServerALPPL2
ExAC (Exome Aggregation Consortium)ALPPL2 (select the gene name)
Genetic variants : HAPMAP251
Genomic Variants (DGV)ALPPL2 [DGVbeta]
DECIPHER (Syndromes)2:233271552-233275424  ENSG00000163286
CONAN: Copy Number AnalysisALPPL2 
Mutations
ICGC Data PortalALPPL2 
TCGA Data PortalALPPL2 
Broad Tumor PortalALPPL2
OASIS PortalALPPL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALPPL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALPPL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALPPL2
DgiDB (Drug Gene Interaction Database)ALPPL2
DoCM (Curated mutations)ALPPL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALPPL2 (select a term)
intoGenALPPL2
Cancer3DALPPL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM171810   
Orphanet
MedgenALPPL2
Genetic Testing Registry ALPPL2
NextProtP10696 [Medical]
TSGene251
GENETestsALPPL2
Huge Navigator ALPPL2 [HugePedia]
snp3D : Map Gene to Disease251
BioCentury BCIQALPPL2
ClinGenALPPL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD251
Chemical/Pharm GKB GenePA24731
Clinical trialALPPL2
Miscellaneous
canSAR (ICR)ALPPL2 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALPPL2
EVEXALPPL2
GoPubMedALPPL2
iHOPALPPL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:55:37 CET 2017

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