ALX1 (ALX homeobox 1)

2014-02-01  

Identity

HGNC
LOCATION
12q21.31
LOCUSID
ALIAS
CART1,FND3,HEL23

Other Information

Locus ID:

NCBI: 8092
MIM: 601527
HGNC: 1494
Ensembl: ENSG00000180318

Variants:

dbSNP: 8092
ClinVar: 8092
TCGA: ENSG00000180318
COSMIC: ALX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180318ENST00000316824Q15699
ENSG00000180318ENST00000316824V9HWA7

Expression (GTEx)

0
1
2
3
4
5
6

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240819452013A prognostic DNA methylation signature for stage I non-small-cell lung cancer.100
204511712010Disruption of ALX1 causes extreme microphthalmia and severe facial clefting: expanding the spectrum of autosomal-recessive ALX-related frontonasal dysplasia.33
232885092013ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian cancer cells.23
209323152010Genes encoding critical transcriptional activators for murine neural tube development and human spina bifida: a case-control study.5
257369242015Depletion of ALX1 causes inhibition of migration and induction of apoptosis in human osteosarcoma.3
267223972015ALX1 promotes migration and invasion of lung cancer cells through increasing snail expression.2
273248662017Exome sequencing revealed a novel splice site variant in the ALX1 gene underlying frontonasal dysplasia.1
270536132016[Knockdown of CART1 induces S phase arrest and inhibits invasion and migration of MDA-MB-231 breast cancer cells].0
299364722018Novel Potential Biomarkers for Opisthorchis viverrini Infection and Associated Cholangiocarcinoma.0
307732582019Knockdown of aristaless-like homeobox1 inhibits epithelial-mesenchymal transition through Wnt/β-catenin signaling pathway in melanoma cells.0

Citation

Dessen P

ALX1 (ALX homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53788/alx1