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ALX3 (ALX homeobox 3)

Identity

Alias_namesFND
aristaless-like homeobox 3
frontonasal dysplasia
Other aliasFND1
HGNC (Hugo) ALX3
LocusID (NCBI) 257
Atlas_Id 54120
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 110060375 and ends at 110070700 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RECK (9p13.3) / ALX3 (1p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALX3   449
Cards
Entrez_Gene (NCBI)ALX3  257  ALX homeobox 3
AliasesFND; FND1
GeneCards (Weizmann)ALX3
Ensembl hg19 (Hinxton)ENSG00000156150 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156150 [Gene_View]  chr1:110060375-110070700 [Contig_View]  ALX3 [Vega]
ICGC DataPortalENSG00000156150
TCGA cBioPortalALX3
AceView (NCBI)ALX3
Genatlas (Paris)ALX3
WikiGenes257
SOURCE (Princeton)ALX3
Genetics Home Reference (NIH)ALX3
Genomic and cartography
GoldenPath hg38 (UCSC)ALX3  -     chr1:110060375-110070700 -  1p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALX3  -     1p13.3   [Description]    (hg19-Feb_2009)
EnsemblALX3 - 1p13.3 [CytoView hg19]  ALX3 - 1p13.3 [CytoView hg38]
Mapping of homologs : NCBIALX3 [Mapview hg19]  ALX3 [Mapview hg38]
OMIM136760   606014   
Gene and transcription
Genbank (Entrez)AF008203 BC112007 BC113428
RefSeq transcript (Entrez)NM_006492
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALX3
Cluster EST : UnigeneHs.669953 [ NCBI ]
CGAP (NCI)Hs.669953
Alternative Splicing GalleryENSG00000156150
Gene ExpressionALX3 [ NCBI-GEO ]   ALX3 [ EBI - ARRAY_EXPRESS ]   ALX3 [ SEEK ]   ALX3 [ MEM ]
Gene Expression Viewer (FireBrowse)ALX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)257
GTEX Portal (Tissue expression)ALX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95076   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95076  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95076
Splice isoforms : SwissVarO95076
PhosPhoSitePlusO95076
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)ALX3    Homeobox-like    Homeobox_CS    Homeobox_dom   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)ALX3
DMDM Disease mutations257
Blocks (Seattle)ALX3
SuperfamilyO95076
Human Protein AtlasENSG00000156150
Peptide AtlasO95076
HPRD16190
IPIIPI00028290   
Protein Interaction databases
DIP (DOE-UCLA)O95076
IntAct (EBI)O95076
FunCoupENSG00000156150
BioGRIDALX3
STRING (EMBL)ALX3
ZODIACALX3
Ontologies - Pathways
QuickGOO95076
Ontology : AmiGOnucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  pattern specification process  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  regulation of apoptotic process  sequence-specific DNA binding  embryonic cranial skeleton morphogenesis  
Ontology : EGO-EBInucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  pattern specification process  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  regulation of apoptotic process  sequence-specific DNA binding  embryonic cranial skeleton morphogenesis  
NDEx NetworkALX3
Atlas of Cancer Signalling NetworkALX3
Wikipedia pathwaysALX3
Orthology - Evolution
OrthoDB257
GeneTree (enSembl)ENSG00000156150
Phylogenetic Trees/Animal Genes : TreeFamALX3
HOVERGENO95076
HOGENOMO95076
Homologs : HomoloGeneALX3
Homology/Alignments : Family Browser (UCSC)ALX3
Gene fusions - Rearrangements
Fusion : MitelmanRECK/ALX3 [9p13.3/1p13.3]  [t(1;9)(p13;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALX3
dbVarALX3
ClinVarALX3
1000_GenomesALX3 
Exome Variant ServerALX3
ExAC (Exome Aggregation Consortium)ALX3 (select the gene name)
Genetic variants : HAPMAP257
Genomic Variants (DGV)ALX3 [DGVbeta]
DECIPHERALX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALX3 
Mutations
ICGC Data PortalALX3 
TCGA Data PortalALX3 
Broad Tumor PortalALX3
OASIS PortalALX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALX3
DgiDB (Drug Gene Interaction Database)ALX3
DoCM (Curated mutations)ALX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALX3 (select a term)
intoGenALX3
Cancer3DALX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM136760    606014   
Orphanet22625   
MedgenALX3
Genetic Testing Registry ALX3
NextProtO95076 [Medical]
TSGene257
GENETestsALX3
Target ValidationALX3
Huge Navigator ALX3 [HugePedia]
snp3D : Map Gene to Disease257
BioCentury BCIQALX3
ClinGenALX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD257
Chemical/Pharm GKB GenePA24754
Clinical trialALX3
Miscellaneous
canSAR (ICR)ALX3 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALX3
EVEXALX3
GoPubMedALX3
iHOPALX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:23:33 CEST 2017

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