Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ALX4 (ALX homeobox 4)

Identity

Alias (NCBI)CRS5
FND2
HGNC (Hugo) ALX4
HGNC Alias symbFPP
PFM
KIAA1788
HGNC Previous namePFM2
HGNC Previous nameparietal foramina 2
 aristaless-like homeobox 4
LocusID (NCBI) 60529
Atlas_Id 52812
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 44260440 and ends at 44310139 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALX4 (11p11.2) / STK33 (11p15.4)EXT2 (11p11.2) / ALX4 (11p11.2)KMT2E (7q22.3) / ALX4 (11p11.2)
ALX4 11p11.2 / STK33 11p15.4EXT2 11p11.2 / ALX4 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)ALX4   450
Cards
Entrez_Gene (NCBI)ALX4    ALX homeobox 4
AliasesCRS5; FND2
GeneCards (Weizmann)ALX4
Ensembl hg19 (Hinxton)ENSG00000052850 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000052850 [Gene_View]  ENSG00000052850 [Sequence]  chr11:44260440-44310139 [Contig_View]  ALX4 [Vega]
ICGC DataPortalENSG00000052850
TCGA cBioPortalALX4
AceView (NCBI)ALX4
Genatlas (Paris)ALX4
SOURCE (Princeton)ALX4
Genetics Home Reference (NIH)ALX4
Genomic and cartography
GoldenPath hg38 (UCSC)ALX4  -     chr11:44260440-44310139 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALX4  -     11p11.2   [Description]    (hg19-Feb_2009)
GoldenPathALX4 - 11p11.2 [CytoView hg19]  ALX4 - 11p11.2 [CytoView hg38]
ImmunoBaseENSG00000052850
genome Data Viewer NCBIALX4 [Mapview hg19]  
OMIM605420   609597   613451   615529   
Gene and transcription
Genbank (Entrez)AB058691 AF294629 AJ404888 AK092346
RefSeq transcript (Entrez)NM_021926
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALX4
Alternative Splicing GalleryENSG00000052850
Gene ExpressionALX4 [ NCBI-GEO ]   ALX4 [ EBI - ARRAY_EXPRESS ]   ALX4 [ SEEK ]   ALX4 [ MEM ]
Gene Expression Viewer (FireBrowse)ALX4 [ Firebrowse - Broad ]
GenevisibleExpression of ALX4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60529
GTEX Portal (Tissue expression)ALX4
Human Protein AtlasENSG00000052850-ALX4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H161   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H161  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H161
Splice isoforms : SwissVarQ9H161
PhosPhoSitePlusQ9H161
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    OAR (PS50803)   
Domains : Interpro (EBI)ALX4    Homeobox-like_sf    Homeobox_CS    Homeobox_dom    OAR_dom   
Domain families : Pfam (Sanger)Homeodomain (PF00046)    OAR (PF03826)   
Domain families : Pfam (NCBI)pfam00046    pfam03826   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)ALX4
Blocks (Seattle)ALX4
PDB (RSDB)2M0C   
PDB Europe2M0C   
PDB (PDBSum)2M0C   
PDB (IMB)2M0C   
Structural Biology KnowledgeBase2M0C   
SCOP (Structural Classification of Proteins)2M0C   
CATH (Classification of proteins structures)2M0C   
SuperfamilyQ9H161
Human Protein Atlas [tissue]ENSG00000052850-ALX4 [tissue]
Peptide AtlasQ9H161
HPRD05661
IPIIPI00334769   
Protein Interaction databases
DIP (DOE-UCLA)Q9H161
IntAct (EBI)Q9H161
BioGRIDALX4
STRING (EMBL)ALX4
ZODIACALX4
Ontologies - Pathways
QuickGOQ9H161
Ontology : AmiGOchromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  skeletal system development  hair follicle development  DNA binding  protein binding  nucleus  nucleus  nucleoplasm  transcription regulator complex  regulation of transcription by RNA polymerase II  muscle organ development  post-embryonic development  anterior/posterior pattern specification  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  embryonic digit morphogenesis  regulation of apoptotic process  positive regulation of transcription by RNA polymerase II  digestive tract development  embryonic skeletal system morphogenesis  roof of mouth development  HMG box domain binding  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBIchromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  skeletal system development  hair follicle development  DNA binding  protein binding  nucleus  nucleus  nucleoplasm  transcription regulator complex  regulation of transcription by RNA polymerase II  muscle organ development  post-embryonic development  anterior/posterior pattern specification  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  embryonic digit morphogenesis  regulation of apoptotic process  positive regulation of transcription by RNA polymerase II  digestive tract development  embryonic skeletal system morphogenesis  roof of mouth development  HMG box domain binding  sequence-specific double-stranded DNA binding  
NDEx NetworkALX4
Atlas of Cancer Signalling NetworkALX4
Wikipedia pathwaysALX4
Orthology - Evolution
OrthoDB60529
GeneTree (enSembl)ENSG00000052850
Phylogenetic Trees/Animal Genes : TreeFamALX4
HOGENOMQ9H161
Homologs : HomoloGeneALX4
Homology/Alignments : Family Browser (UCSC)ALX4
Gene fusions - Rearrangements
Fusion : MitelmanALX4/STK33 [11p11.2/11p15.4]  
Fusion : MitelmanEXT2/ALX4 [11p11.2/11p11.2]  
Fusion PortalALX4 11p11.2 STK33 11p15.4 BRCA
Fusion PortalEXT2 11p11.2 ALX4 11p11.2 BRCA
Fusion : QuiverALX4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALX4 [hg38]
dbVarALX4
ClinVarALX4
MonarchALX4
1000_GenomesALX4 
Exome Variant ServerALX4
GNOMAD BrowserENSG00000052850
Varsome BrowserALX4
Genomic Variants (DGV)ALX4 [DGVbeta]
DECIPHERALX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALX4 
Mutations
ICGC Data PortalALX4 
TCGA Data PortalALX4 
Broad Tumor PortalALX4
OASIS PortalALX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALX4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DALX4
Mutations and Diseases : HGMDALX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALX4
DgiDB (Drug Gene Interaction Database)ALX4
DoCM (Curated mutations)ALX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALX4 (select a term)
intoGenALX4
Cancer3DALX4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605420    609597    613451    615529   
Orphanet19121    10796    10367    10684   
DisGeNETALX4
MedgenALX4
Genetic Testing Registry ALX4
NextProtQ9H161 [Medical]
GENETestsALX4
Target ValidationALX4
Huge Navigator ALX4 [HugePedia]
ClinGenALX4 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeALX4
Protein Interactions : CTD
Pharm GKB GenePA24755
PharosQ9H161
Clinical trialALX4
Miscellaneous
canSAR (ICR)ALX4 (select the gene name)
HarmonizomeALX4
DataMed IndexALX4
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXALX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:10:44 CET 2021

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