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ALX4 (ALX homeobox 4)

Identity

Other namesCRS5
FND2
HGNC (Hugo) ALX4
LocusID (NCBI) 60529
Atlas_Id 52812
Location 11p11.2
Location_base_pair Starts at 44282278 and ends at 44331716 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
ALX4 11p11.2 / STK33 11p15.4EXT2 11p11.2 / ALX4 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALX4   450
Cards
Entrez_Gene (NCBI)ALX4  60529  ALX homeobox 4
GeneCards (Weizmann)ALX4
Ensembl hg19 (Hinxton)ENSG00000052850 [Gene_View]  chr11:44282278-44331716 [Contig_View]  ALX4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000052850 [Gene_View]  chr11:44282278-44331716 [Contig_View]  ALX4 [Vega]
ICGC DataPortalENSG00000052850
TCGA cBioPortalALX4
AceView (NCBI)ALX4
Genatlas (Paris)ALX4
WikiGenes60529
SOURCE (Princeton)ALX4
Genomic and cartography
GoldenPath hg19 (UCSC)ALX4  -     chr11:44282278-44331716 -  11p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALX4  -     11p11.2   [Description]    (hg38-Dec_2013)
EnsemblALX4 - 11p11.2 [CytoView hg19]  ALX4 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIALX4 [Mapview hg19]  ALX4 [Mapview hg38]
OMIM605420   609597   613451   615529   
Gene and transcription
Genbank (Entrez)AB058691 AF294629 AJ404888 AK092346 BC166622
RefSeq transcript (Entrez)NM_021926
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_015809 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)ALX4
Cluster EST : UnigeneHs.436055 [ NCBI ]
CGAP (NCI)Hs.436055
Alternative Splicing : Fast-db (Paris)GSHG0005713
Alternative Splicing GalleryENSG00000052850
Gene ExpressionALX4 [ NCBI-GEO ]     ALX4 [ SEEK ]   ALX4 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)60529
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H161 (Uniprot)
NextProtQ9H161  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H161
Splice isoforms : SwissVarQ9H161 (Swissvar)
PhosPhoSitePlusQ9H161
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    OAR (PS50803)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    OAR_dom   
Domain families : Pfam (Sanger)Homeobox (PF00046)    OAR (PF03826)   
Domain families : Pfam (NCBI)pfam00046    pfam03826   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations60529
Blocks (Seattle)ALX4
PDB (SRS)2M0C   
PDB (PDBSum)2M0C   
PDB (IMB)2M0C   
PDB (RSDB)2M0C   
Structural Biology KnowledgeBase2M0C   
SCOP (Structural Classification of Proteins)2M0C   
CATH (Classification of proteins structures)2M0C   
Human Protein AtlasENSG00000052850
Peptide AtlasQ9H161
HPRD05661
IPIIPI00334769   
Protein Interaction databases
DIP (DOE-UCLA)Q9H161
IntAct (EBI)Q9H161
FunCoupENSG00000052850
BioGRIDALX4
IntegromeDBALX4
STRING (EMBL)ALX4
ZODIACALX4
Ontologies - Pathways
QuickGOQ9H161
Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  skeletal system development  hair follicle development  DNA binding  nucleus  nucleus  transcription factor complex  transcription from RNA polymerase II promoter  muscle organ development  post-embryonic development  anterior/posterior pattern specification  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  embryonic digit morphogenesis  regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  digestive tract development  embryonic skeletal system morphogenesis  palate development  HMG box domain binding  
Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  skeletal system development  hair follicle development  DNA binding  nucleus  nucleus  transcription factor complex  transcription from RNA polymerase II promoter  muscle organ development  post-embryonic development  anterior/posterior pattern specification  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  embryonic digit morphogenesis  regulation of apoptotic process  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  digestive tract development  embryonic skeletal system morphogenesis  palate development  HMG box domain binding  
Protein Interaction DatabaseALX4
Atlas of Cancer Signalling NetworkALX4
Wikipedia pathwaysALX4
Orthology - Evolution
OrthoDB60529
GeneTree (enSembl)ENSG00000052850
Phylogenetic Trees/Animal Genes : TreeFamALX4
Homologs : HomoloGeneALX4
Homology/Alignments : Family Browser (UCSC)ALX4
Gene fusions - Rearrangements
Fusion: TCGAALX4 11p11.2 STK33 11p15.4 BRCA
Fusion: TCGAEXT2 11p11.2 ALX4 11p11.2 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerALX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALX4
dbVarALX4
ClinVarALX4
1000_GenomesALX4 
Exome Variant ServerALX4
Exome Aggregation Consortium (ExAC)ENSG00000052850
SNP (GeneSNP Utah)ALX4
SNP : HGBaseALX4
Genetic variants : HAPMAPALX4
Genomic Variants (DGV)ALX4 [DGVbeta]
Mutations
ICGC Data PortalALX4 
TCGA Data PortalALX4 
Tumor PortalALX4
TCGA Copy Number PortalALX4
Somatic Mutations in Cancer : COSMICALX4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALX4
DgiDB (Drug Gene Interaction Database)ALX4
DoCM (Curated mutations)ALX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALX4 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:44282278-44331716
CONAN: Copy Number AnalysisALX4 
Mutations and Diseases : HGMDALX4
OMIM605420    609597    613451    615529   
MedgenALX4
NextProtQ9H161 [Medical]
TSGene60529
GENETestsALX4
Huge Navigator ALX4 [HugePedia]  ALX4 [HugeCancerGEM]
snp3D : Map Gene to Disease60529
BioCentury BCIQALX4
General knowledge
Chemical/Protein Interactions : CTD60529
Chemical/Pharm GKB GenePA24755
Clinical trialALX4
Other databases
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALX4
GoPubMedALX4
iHOPALX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 18:07:04 CET 2016

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