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ALX4 (ALX homeobox 4)

Identity

Other namesCRS5
FND2
HGNC (Hugo) ALX4
LocusID (NCBI) 60529
Location 11p11.2
Location_base_pair Starts at 44282278 and ends at 44331716 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)ALX4   450
Cards
Entrez_Gene (NCBI)ALX4  60529  ALX homeobox 4
GeneCards (Weizmann)ALX4
Ensembl hg19 (Hinxton)ENSG00000052850 [Gene_View]  chr11:44282278-44331716 [Contig_View]  ALX4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000052850 [Gene_View]  chr11:44282278-44331716 [Contig_View]  ALX4 [Vega]
ICGC DataPortalENSG00000052850
cBioPortalALX4
AceView (NCBI)ALX4
Genatlas (Paris)ALX4
WikiGenes60529
SOURCE (Princeton)ALX4
Genomic and cartography
GoldenPath hg19 (UCSC)ALX4  -     chr11:44282278-44331716 -  11p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALX4  -     11p11.2   [Description]    (hg38-Dec_2013)
EnsemblALX4 - 11p11.2 [CytoView hg19]  ALX4 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIALX4 [Mapview hg19]  ALX4 [Mapview hg38]
OMIM605420   609597   613451   615529   
Gene and transcription
Genbank (Entrez)AB058691 AF294629 AJ404888 AK092346 BC166622
RefSeq transcript (Entrez)NM_021926
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_015809 NT_009237 NW_001838022 NW_004929378
Consensus coding sequences : CCDS (NCBI)ALX4
Cluster EST : UnigeneHs.436055 [ NCBI ]
CGAP (NCI)Hs.436055
Alternative Splicing : Fast-db (Paris)GSHG0005713
Alternative Splicing GalleryENSG00000052850
Gene ExpressionALX4 [ NCBI-GEO ]     ALX4 [ SEEK ]   ALX4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H161 (Uniprot)
NextProtQ9H161  [Medical]
With graphics : InterProQ9H161
Splice isoforms : SwissVarQ9H161 (Swissvar)
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)    OAR (PS50803)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    OAR_dom   
Related proteins : CluSTrQ9H161
Domain families : Pfam (Sanger)Homeobox (PF00046)    OAR (PF03826)   
Domain families : Pfam (NCBI)pfam00046    pfam03826   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations60529
Blocks (Seattle)Q9H161
PDB (SRS)2M0C   
PDB (PDBSum)2M0C   
PDB (IMB)2M0C   
PDB (RSDB)2M0C   
Human Protein AtlasENSG00000052850
Peptide AtlasQ9H161
HPRD05661
IPIIPI00334769   
Protein Interaction databases
DIP (DOE-UCLA)Q9H161
IntAct (EBI)Q9H161
FunCoupENSG00000052850
BioGRIDALX4
IntegromeDBALX4
STRING (EMBL)ALX4
Ontologies - Pathways
QuickGOQ9H161
Ontology : AmiGOskeletal system development  hair follicle development  DNA binding  sequence-specific DNA binding transcription factor activity  nucleus  nucleus  transcription factor complex  transcription, DNA-templated  muscle organ development  post-embryonic development  anterior/posterior pattern specification  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  embryonic digit morphogenesis  regulation of apoptotic process  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  digestive tract development  embryonic skeletal system morphogenesis  palate development  HMG box domain binding  
Ontology : EGO-EBIskeletal system development  hair follicle development  DNA binding  sequence-specific DNA binding transcription factor activity  nucleus  nucleus  transcription factor complex  transcription, DNA-templated  muscle organ development  post-embryonic development  anterior/posterior pattern specification  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  embryonic digit morphogenesis  regulation of apoptotic process  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  digestive tract development  embryonic skeletal system morphogenesis  palate development  HMG box domain binding  
Protein Interaction DatabaseALX4
DoCM (Curated mutations)ALX4
Wikipedia pathwaysALX4
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerALX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALX4
dbVarALX4
ClinVarALX4
1000_GenomesALX4 
Exome Variant ServerALX4
SNP (GeneSNP Utah)ALX4
SNP : HGBaseALX4
Genetic variants : HAPMAPALX4
Genomic VariantsALX4  ALX4 [DGVbeta]
Mutations
ICGC Data PortalENSG00000052850 
Somatic Mutations in Cancer : COSMICALX4 
CONAN: Copy Number AnalysisALX4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:44282278-44331716
Mutations and Diseases : HGMDALX4
OMIM605420    609597    613451    615529   
MedgenALX4
NextProtQ9H161 [Medical]
GENETestsALX4
Disease Genetic AssociationALX4
Huge Navigator ALX4 [HugePedia]  ALX4 [HugeCancerGEM]
snp3D : Map Gene to Disease60529
DGIdb (Drug Gene Interaction db)ALX4
General knowledge
Homologs : HomoloGeneALX4
Homology/Alignments : Family Browser (UCSC)ALX4
Phylogenetic Trees/Animal Genes : TreeFamALX4
Chemical/Protein Interactions : CTD60529
Chemical/Pharm GKB GenePA24755
Clinical trialALX4
Cancer Resource (Charite)ENSG00000052850
Other databases
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
CoreMineALX4
GoPubMedALX4
iHOPALX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 20:06:14 CET 2014

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