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ALYREF (Aly/REF export factor)

Identity

Alias_namesTHOC4
THO complex 4
Alias_symbol (synonym)ALY
BEF
ALY/REF
REF
Other alias
HGNC (Hugo) ALYREF
LocusID (NCBI) 10189
Atlas_Id 47636
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81887835 and ends at 81891586 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ALYREF (17q25.3) / PRDX3 (10q26.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALYREF   19071
Cards
Entrez_Gene (NCBI)ALYREF  10189  Aly/REF export factor
AliasesALY; ALY/REF; BEF; REF; 
THOC4
GeneCards (Weizmann)ALYREF
Ensembl hg19 (Hinxton)ENSG00000183684 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183684 [Gene_View]  chr17:81887835-81891586 [Contig_View]  ALYREF [Vega]
ICGC DataPortalENSG00000183684
TCGA cBioPortalALYREF
AceView (NCBI)ALYREF
Genatlas (Paris)ALYREF
WikiGenes10189
SOURCE (Princeton)ALYREF
Genetics Home Reference (NIH)ALYREF
Genomic and cartography
GoldenPath hg38 (UCSC)ALYREF  -     chr17:81887835-81891586 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ALYREF  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblALYREF - 17q25.3 [CytoView hg19]  ALYREF - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBIALYREF [Mapview hg19]  ALYREF [Mapview hg38]
OMIM604171   
Gene and transcription
Genbank (Entrez)AF047002 AF086513 BC052302 BU624466 EU831428
RefSeq transcript (Entrez)NM_005782
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ALYREF
Cluster EST : UnigeneHs.534385 [ NCBI ]
CGAP (NCI)Hs.534385
Alternative Splicing GalleryENSG00000183684
Gene ExpressionALYREF [ NCBI-GEO ]   ALYREF [ EBI - ARRAY_EXPRESS ]   ALYREF [ SEEK ]   ALYREF [ MEM ]
Gene Expression Viewer (FireBrowse)ALYREF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10189
GTEX Portal (Tissue expression)ALYREF
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86V81   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86V81  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86V81
Splice isoforms : SwissVarQ86V81
PhosPhoSitePlusQ86V81
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)FoP_C    Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)FoP_duplication (PF13865)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam13865    pfam00076   
Domain families : Smart (EMBL)FoP_duplication (SM01218)  RRM (SM00360)  
Conserved Domain (NCBI)ALYREF
DMDM Disease mutations10189
Blocks (Seattle)ALYREF
PDB (SRS)3ULH   
PDB (PDBSum)3ULH   
PDB (IMB)3ULH   
PDB (RSDB)3ULH   
Structural Biology KnowledgeBase3ULH   
SCOP (Structural Classification of Proteins)3ULH   
CATH (Classification of proteins structures)3ULH   
SuperfamilyQ86V81
Human Protein AtlasENSG00000183684
Peptide AtlasQ86V81
HPRD09168
IPIIPI01010794   IPI00328840   
Protein Interaction databases
DIP (DOE-UCLA)Q86V81
IntAct (EBI)Q86V81
FunCoupENSG00000183684
BioGRIDALYREF
STRING (EMBL)ALYREF
ZODIACALYREF
Ontologies - Pathways
QuickGOQ86V81
Ontology : AmiGOregulation of DNA recombination  transcription export complex  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  nuclear chromosome, telomeric region  osteoblast differentiation  RNA binding  protein binding  nucleoplasm  cytosol  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  membrane  nuclear speck  mRNA 3'-end processing  replication fork processing  positive regulation of DNA-templated transcription, elongation  exon-exon junction complex  viral mRNA export from host cell nucleus  extracellular exosome  catalytic step 2 spliceosome  
Ontology : EGO-EBIregulation of DNA recombination  transcription export complex  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  nuclear chromosome, telomeric region  osteoblast differentiation  RNA binding  protein binding  nucleoplasm  cytosol  termination of RNA polymerase II transcription  RNA export from nucleus  mRNA export from nucleus  mRNA export from nucleus  membrane  nuclear speck  mRNA 3'-end processing  replication fork processing  positive regulation of DNA-templated transcription, elongation  exon-exon junction complex  viral mRNA export from host cell nucleus  extracellular exosome  catalytic step 2 spliceosome  
Pathways : KEGGRNA transport    mRNA surveillance pathway    Spliceosome    Herpes simplex infection   
NDEx NetworkALYREF
Atlas of Cancer Signalling NetworkALYREF
Wikipedia pathwaysALYREF
Orthology - Evolution
OrthoDB10189
GeneTree (enSembl)ENSG00000183684
Phylogenetic Trees/Animal Genes : TreeFamALYREF
HOVERGENQ86V81
HOGENOMQ86V81
Homologs : HomoloGeneALYREF
Homology/Alignments : Family Browser (UCSC)ALYREF
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALYREF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALYREF
dbVarALYREF
ClinVarALYREF
1000_GenomesALYREF 
Exome Variant ServerALYREF
ExAC (Exome Aggregation Consortium)ALYREF (select the gene name)
Genetic variants : HAPMAP10189
Genomic Variants (DGV)ALYREF [DGVbeta]
DECIPHERALYREF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisALYREF 
Mutations
ICGC Data PortalALYREF 
TCGA Data PortalALYREF 
Broad Tumor PortalALYREF
OASIS PortalALYREF [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDALYREF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALYREF
DgiDB (Drug Gene Interaction Database)ALYREF
DoCM (Curated mutations)ALYREF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALYREF (select a term)
intoGenALYREF
Cancer3DALYREF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604171   
Orphanet
MedgenALYREF
Genetic Testing Registry ALYREF
NextProtQ86V81 [Medical]
TSGene10189
GENETestsALYREF
Target ValidationALYREF
Huge Navigator ALYREF [HugePedia]
snp3D : Map Gene to Disease10189
BioCentury BCIQALYREF
ClinGenALYREF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10189
Chemical/Pharm GKB GenePA134925107
Clinical trialALYREF
Miscellaneous
canSAR (ICR)ALYREF (select the gene name)
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALYREF
EVEXALYREF
GoPubMedALYREF
iHOPALYREF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:54:52 CEST 2017

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