AMACR (alpha-methylacyl-CoA racemase)

2012-08-01  

Identity

HGNC
AMACR
LOCATION
5p13.2
LOCUSID
23600
ALIAS
AMACRD,CBAS4,P504S,RACE,RM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23600
MIM: 604489
HGNC: 451
Ensembl: ENSG00000242110

Variants:

dbSNP: 23600
ClinVar: 23600
TCGA: ENSG00000242110
COSMIC: AMACR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242110ENST00000335606Q9UHK6
ENSG00000242110ENST00000382068V9GYU9
ENSG00000242110ENST00000382072Q9UHK6
ENSG00000242110ENST00000382085Q9UHK6
ENSG00000242110ENST00000426255V9GYP4
ENSG00000242110ENST00000502637D6RB81
ENSG00000242110ENST00000506639Q9UHK6
ENSG00000242110ENST00000512079V9GZ45

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Primary bile acid biosynthesisKEGGko00120
Primary bile acid biosynthesisKEGGhsa00120
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholateKEGGhsa_M00104
Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholateKEGGM00104
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Peroxisomal lipid metabolismREACTOMER-HSA-390918
Beta-oxidation of pristanoyl-CoAREACTOMER-HSA-389887
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Synthesis of bile acids and bile saltsREACTOMER-HSA-192105
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolREACTOMER-HSA-193368
Synthesis of bile acids and bile salts via 24-hydroxycholesterolREACTOMER-HSA-193775

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166160055cholic acidChemicalLabelAnnotationassociated
PA449957ibuprofenChemicalPathwayassociated25502615

References

Pubmed IDYearTitleCitations
119268902002alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer.136
146125352003Alpha-methylacyl-CoA racemase as an androgen-independent growth modifier in prostate cancer.33
122137122002alpha-Methylacyl-CoA racemase: expression levels of this novel cancer biomarker depend on tumor differentiation.32
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
159419512005Decreased alpha-methylacyl CoA racemase expression in localized prostate cancer is associated with an increased rate of biochemical recurrence and cancer-specific death.29
153307992004Alpha-methylacyl-CoA racemase: a multi-institutional study of a new prostate cancer marker.26
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
182793922008Alpha-methylacyl-CoA racemase--an 'obscure' metabolic enzyme takes centre stage.22
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.20
164914802006The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase.19

Citation

Dessen P

AMACR (alpha-methylacyl-CoA racemase)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52843/amacr