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AMIGO2 (adhesion molecule with Ig like domain 2)

Identity

Alias_symbol (synonym)ALI1
DEGA
Other aliasAMIGO-2
HGNC (Hugo) AMIGO2
LocusID (NCBI) 347902
Atlas_Id 46394
Location 12q13.11  [Link to chromosome band 12q13]
Location_base_pair Starts at 47075707 and ends at 47079951 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NNT (5p12) / AMIGO2 (12q13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(5;12)(p12;q13) NNT/AMIGO2


External links

Nomenclature
HGNC (Hugo)AMIGO2   24073
Cards
Entrez_Gene (NCBI)AMIGO2  347902  adhesion molecule with Ig like domain 2
AliasesALI1; AMIGO-2; DEGA
GeneCards (Weizmann)AMIGO2
Ensembl hg19 (Hinxton)ENSG00000139211 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139211 [Gene_View]  ENSG00000139211 [Sequence]  chr12:47075707-47079951 [Contig_View]  AMIGO2 [Vega]
ICGC DataPortalENSG00000139211
TCGA cBioPortalAMIGO2
AceView (NCBI)AMIGO2
Genatlas (Paris)AMIGO2
WikiGenes347902
SOURCE (Princeton)AMIGO2
Genetics Home Reference (NIH)AMIGO2
Genomic and cartography
GoldenPath hg38 (UCSC)AMIGO2  -     chr12:47075707-47079951 -  12q13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AMIGO2  -     12q13.11   [Description]    (hg19-Feb_2009)
EnsemblAMIGO2 - 12q13.11 [CytoView hg19]  AMIGO2 - 12q13.11 [CytoView hg38]
Mapping of homologs : NCBIAMIGO2 [Mapview hg19]  AMIGO2 [Mapview hg38]
OMIM615690   
Gene and transcription
Genbank (Entrez)AB079074 AB080610 AK091761 AK093111 AL833007
RefSeq transcript (Entrez)NM_001143668 NM_181847
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AMIGO2
Cluster EST : UnigeneHs.121520 [ NCBI ]
CGAP (NCI)Hs.121520
Alternative Splicing GalleryENSG00000139211
Gene ExpressionAMIGO2 [ NCBI-GEO ]   AMIGO2 [ EBI - ARRAY_EXPRESS ]   AMIGO2 [ SEEK ]   AMIGO2 [ MEM ]
Gene Expression Viewer (FireBrowse)AMIGO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)347902
GTEX Portal (Tissue expression)AMIGO2
Human Protein AtlasENSG00000139211-AMIGO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86SJ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86SJ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86SJ2
Splice isoforms : SwissVarQ86SJ2
PhosPhoSitePlusQ86SJ2
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    LRR (PS51450)   
Domains : Interpro (EBI)AMIGO    AMIGO2    Cys-rich_flank_reg_C    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Immunoglobulin    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf   
Domain families : Pfam (Sanger)ig (PF00047)    LRR_1 (PF00560)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam00047    pfam00560    pfam13855   
Domain families : Smart (EMBL)IG (SM00409)  LRR_TYP (SM00369)  LRRCT (SM00082)  
Conserved Domain (NCBI)AMIGO2
DMDM Disease mutations347902
Blocks (Seattle)AMIGO2
SuperfamilyQ86SJ2
Human Protein Atlas [tissue]ENSG00000139211-AMIGO2 [tissue]
Peptide AtlasQ86SJ2
HPRD16483
IPIIPI00238262   
Protein Interaction databases
DIP (DOE-UCLA)Q86SJ2
IntAct (EBI)Q86SJ2
FunCoupENSG00000139211
BioGRIDAMIGO2
STRING (EMBL)AMIGO2
ZODIACAMIGO2
Ontologies - Pathways
QuickGOQ86SJ2
Ontology : AmiGOprotein binding  nucleus  plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  integral component of membrane  negative regulation of apoptotic process  negative regulation of programmed cell death  positive regulation of synapse assembly  
Ontology : EGO-EBIprotein binding  nucleus  plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  integral component of membrane  negative regulation of apoptotic process  negative regulation of programmed cell death  positive regulation of synapse assembly  
NDEx NetworkAMIGO2
Atlas of Cancer Signalling NetworkAMIGO2
Wikipedia pathwaysAMIGO2
Orthology - Evolution
OrthoDB347902
GeneTree (enSembl)ENSG00000139211
Phylogenetic Trees/Animal Genes : TreeFamAMIGO2
HOVERGENQ86SJ2
HOGENOMQ86SJ2
Homologs : HomoloGeneAMIGO2
Homology/Alignments : Family Browser (UCSC)AMIGO2
Gene fusions - Rearrangements
Fusion : MitelmanNNT/AMIGO2 [5p12/12q13.11]  [t(5;12)(p12;q13)]  
Fusion : QuiverAMIGO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAMIGO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AMIGO2
dbVarAMIGO2
ClinVarAMIGO2
1000_GenomesAMIGO2 
Exome Variant ServerAMIGO2
ExAC (Exome Aggregation Consortium)ENSG00000139211
GNOMAD BrowserENSG00000139211
Varsome BrowserAMIGO2
Genetic variants : HAPMAP347902
Genomic Variants (DGV)AMIGO2 [DGVbeta]
DECIPHERAMIGO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAMIGO2 
Mutations
ICGC Data PortalAMIGO2 
TCGA Data PortalAMIGO2 
Broad Tumor PortalAMIGO2
OASIS PortalAMIGO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAMIGO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAMIGO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AMIGO2
DgiDB (Drug Gene Interaction Database)AMIGO2
DoCM (Curated mutations)AMIGO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AMIGO2 (select a term)
intoGenAMIGO2
Cancer3DAMIGO2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615690   
Orphanet
DisGeNETAMIGO2
MedgenAMIGO2
Genetic Testing Registry AMIGO2
NextProtQ86SJ2 [Medical]
TSGene347902
GENETestsAMIGO2
Target ValidationAMIGO2
Huge Navigator AMIGO2 [HugePedia]
snp3D : Map Gene to Disease347902
BioCentury BCIQAMIGO2
ClinGenAMIGO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD347902
Chemical/Pharm GKB GenePA142672626
Clinical trialAMIGO2
Miscellaneous
canSAR (ICR)AMIGO2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAMIGO2
EVEXAMIGO2
GoPubMedAMIGO2
iHOPAMIGO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:50:58 CET 2018

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