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AMOTL1 (angiomotin like 1)

Identity

Alias_symbol (synonym)JEAP
Other alias
HGNC (Hugo) AMOTL1
LocusID (NCBI) 154810
Atlas_Id 52612
Location 11q21  [Link to chromosome band 11q21]
Location_base_pair Starts at 94501508 and ends at 94609918 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AMOTL1 (11q21) / CCDC88B (11q13.1)AMOTL1 (11q21) / PPIF (10q22.3)AMOTL1 (11q21) / SLCO2B1 (11q13.4)
MPPED2 (11p14.1) / AMOTL1 (11q21)PIR-FIGF (Xp22.2) / AMOTL1 (11q21)SMARCD2 (17q23.3) / AMOTL1 (11q21)
AMOTL1 11q21 / CCDC88B 11q13.1AMOTL1 11q21 / SLCO2B1 11q13.4MPPED2 11p14.1 / AMOTL1 11q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AMOTL1   17811
Cards
Entrez_Gene (NCBI)AMOTL1  154810  angiomotin like 1
AliasesJEAP
GeneCards (Weizmann)AMOTL1
Ensembl hg19 (Hinxton)ENSG00000166025 [Gene_View]  chr11:94501508-94609918 [Contig_View]  AMOTL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000166025 [Gene_View]  chr11:94501508-94609918 [Contig_View]  AMOTL1 [Vega]
ICGC DataPortalENSG00000166025
TCGA cBioPortalAMOTL1
AceView (NCBI)AMOTL1
Genatlas (Paris)AMOTL1
WikiGenes154810
SOURCE (Princeton)AMOTL1
Genetics Home Reference (NIH)AMOTL1
Genomic and cartography
GoldenPath hg19 (UCSC)AMOTL1  -     chr11:94501508-94609918 +  11q21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AMOTL1  -     11q21   [Description]    (hg38-Dec_2013)
EnsemblAMOTL1 - 11q21 [CytoView hg19]  AMOTL1 - 11q21 [CytoView hg38]
Mapping of homologs : NCBIAMOTL1 [Mapview hg19]  AMOTL1 [Mapview hg38]
OMIM614657   
Gene and transcription
Genbank (Entrez)AF453742 AK024350 AK074084 AK093699 AL137281
RefSeq transcript (Entrez)NM_001301007 NM_130847
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929380
Consensus coding sequences : CCDS (NCBI)AMOTL1
Cluster EST : UnigeneHs.503594 [ NCBI ]
CGAP (NCI)Hs.503594
Alternative Splicing GalleryENSG00000166025
Gene ExpressionAMOTL1 [ NCBI-GEO ]   AMOTL1 [ EBI - ARRAY_EXPRESS ]   AMOTL1 [ SEEK ]   AMOTL1 [ MEM ]
Gene Expression Viewer (FireBrowse)AMOTL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)154810
GTEX Portal (Tissue expression)AMOTL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IY63   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IY63  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IY63
Splice isoforms : SwissVarQ8IY63
PhosPhoSitePlusQ8IY63
Domains : Interpro (EBI)Angiomotin    Angiomotin_C   
Domain families : Pfam (Sanger)Angiomotin_C (PF12240)   
Domain families : Pfam (NCBI)pfam12240   
Conserved Domain (NCBI)AMOTL1
DMDM Disease mutations154810
Blocks (Seattle)AMOTL1
SuperfamilyQ8IY63
Human Protein AtlasENSG00000166025
Peptide AtlasQ8IY63
HPRD12451
IPIIPI00217664   IPI00651638   IPI00186093   IPI00942192   IPI00179037   
Protein Interaction databases
DIP (DOE-UCLA)Q8IY63
IntAct (EBI)Q8IY63
FunCoupENSG00000166025
BioGRIDAMOTL1
STRING (EMBL)AMOTL1
ZODIACAMOTL1
Ontologies - Pathways
QuickGOQ8IY63
Ontology : AmiGOestablishment of cell polarity involved in ameboidal cell migration  protein binding  cytoplasm  cytosol  bicellular tight junction  COP9 signalosome  Wnt signaling pathway  apical plasma membrane  lamellipodium  cell junction  cytoplasmic vesicle  hippo signaling  identical protein binding  positive regulation of blood vessel endothelial cell migration  
Ontology : EGO-EBIestablishment of cell polarity involved in ameboidal cell migration  protein binding  cytoplasm  cytosol  bicellular tight junction  COP9 signalosome  Wnt signaling pathway  apical plasma membrane  lamellipodium  cell junction  cytoplasmic vesicle  hippo signaling  identical protein binding  positive regulation of blood vessel endothelial cell migration  
Pathways : KEGGTight junction   
NDEx NetworkAMOTL1
Atlas of Cancer Signalling NetworkAMOTL1
Wikipedia pathwaysAMOTL1
Orthology - Evolution
OrthoDB154810
GeneTree (enSembl)ENSG00000166025
Phylogenetic Trees/Animal Genes : TreeFamAMOTL1
HOVERGENQ8IY63
HOGENOMQ8IY63
Homologs : HomoloGeneAMOTL1
Homology/Alignments : Family Browser (UCSC)AMOTL1
Gene fusions - Rearrangements
Fusion : MitelmanAMOTL1/CCDC88B [11q21/11q13.1]  
Fusion : MitelmanAMOTL1/SLCO2B1 [11q21/11q13.4]  [t(11;11)(q13;q21)]  
Fusion : MitelmanMPPED2/AMOTL1 [11p14.1/11q21]  [t(11;11)(p14;q21)]  
Fusion: TCGAAMOTL1 11q21 CCDC88B 11q13.1 LGG
Fusion: TCGAAMOTL1 11q21 SLCO2B1 11q13.4 BLCA
Fusion: TCGAMPPED2 11p14.1 AMOTL1 11q21 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAMOTL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AMOTL1
dbVarAMOTL1
ClinVarAMOTL1
1000_GenomesAMOTL1 
Exome Variant ServerAMOTL1
ExAC (Exome Aggregation Consortium)AMOTL1 (select the gene name)
Genetic variants : HAPMAP154810
Genomic Variants (DGV)AMOTL1 [DGVbeta]
DECIPHER (Syndromes)11:94501508-94609918  ENSG00000166025
CONAN: Copy Number AnalysisAMOTL1 
Mutations
ICGC Data PortalAMOTL1 
TCGA Data PortalAMOTL1 
Broad Tumor PortalAMOTL1
OASIS PortalAMOTL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAMOTL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAMOTL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AMOTL1
DgiDB (Drug Gene Interaction Database)AMOTL1
DoCM (Curated mutations)AMOTL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AMOTL1 (select a term)
intoGenAMOTL1
Cancer3DAMOTL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614657   
Orphanet
MedgenAMOTL1
Genetic Testing Registry AMOTL1
NextProtQ8IY63 [Medical]
TSGene154810
GENETestsAMOTL1
Huge Navigator AMOTL1 [HugePedia]
snp3D : Map Gene to Disease154810
BioCentury BCIQAMOTL1
ClinGenAMOTL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD154810
Chemical/Pharm GKB GenePA24774
Clinical trialAMOTL1
Miscellaneous
canSAR (ICR)AMOTL1 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAMOTL1
EVEXAMOTL1
GoPubMedAMOTL1
iHOPAMOTL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 14:52:18 CEST 2017

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