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AMT (aminomethyltransferase)

Identity

Alias_namesaminomethyltransferase (glycine cleavage system protein T)
Alias_symbol (synonym)GCST
NKH
Other aliasGCE
GCVT
HGNC (Hugo) AMT
LocusID (NCBI) 275
Atlas_Id 60279
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49416778 and ends at 49422678 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMT (3p21.31) / SMTN (22q12.2)SMTN (22q12.2) / AMT (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AMT   473
LRG (Locus Reference Genomic)LRG_537
Cards
Entrez_Gene (NCBI)AMT  275  aminomethyltransferase
AliasesGCE; GCST; GCVT; NKH
GeneCards (Weizmann)AMT
Ensembl hg19 (Hinxton)ENSG00000145020 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145020 [Gene_View]  chr3:49416778-49422678 [Contig_View]  AMT [Vega]
ICGC DataPortalENSG00000145020
TCGA cBioPortalAMT
AceView (NCBI)AMT
Genatlas (Paris)AMT
WikiGenes275
SOURCE (Princeton)AMT
Genetics Home Reference (NIH)AMT
Genomic and cartography
GoldenPath hg38 (UCSC)AMT  -     chr3:49416778-49422678 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AMT  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblAMT - 3p21.31 [CytoView hg19]  AMT - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIAMT [Mapview hg19]  AMT [Mapview hg38]
OMIM238310   605899   
Gene and transcription
Genbank (Entrez)AK091738 AK096062 AK290600 AK293481 AK293594
RefSeq transcript (Entrez)NM_000481 NM_001164710 NM_001164711 NM_001164712
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AMT
Cluster EST : UnigeneHs.102 [ NCBI ]
CGAP (NCI)Hs.102
Alternative Splicing GalleryENSG00000145020
Gene ExpressionAMT [ NCBI-GEO ]   AMT [ EBI - ARRAY_EXPRESS ]   AMT [ SEEK ]   AMT [ MEM ]
Gene Expression Viewer (FireBrowse)AMT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)275
GTEX Portal (Tissue expression)AMT
Human Protein AtlasENSG00000145020-AMT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48728   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48728  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48728
Splice isoforms : SwissVarP48728
PhosPhoSitePlusP48728
Domains : Interpro (EBI)GCS_T    GCST/DmdA    GCV_T_C    GCV_T_N    GcvT/YgfZ_C    TrmE/GcvT_dom1   
Domain families : Pfam (Sanger)GCV_T (PF01571)    GCV_T_C (PF08669)   
Domain families : Pfam (NCBI)pfam01571    pfam08669   
Conserved Domain (NCBI)AMT
DMDM Disease mutations275
Blocks (Seattle)AMT
PDB (SRS)1WSR    1WSV   
PDB (PDBSum)1WSR    1WSV   
PDB (IMB)1WSR    1WSV   
PDB (RSDB)1WSR    1WSV   
Structural Biology KnowledgeBase1WSR    1WSV   
SCOP (Structural Classification of Proteins)1WSR    1WSV   
CATH (Classification of proteins structures)1WSR    1WSV   
SuperfamilyP48728
Human Protein Atlas [tissue]ENSG00000145020-AMT [tissue]
Peptide AtlasP48728
HPRD01997
IPIIPI00299300   IPI00903299   IPI01015421   IPI00644993   IPI00925396   IPI00793058   IPI00910686   IPI00925305   
Protein Interaction databases
DIP (DOE-UCLA)P48728
IntAct (EBI)P48728
FunCoupENSG00000145020
BioGRIDAMT
STRING (EMBL)AMT
ZODIACAMT
Ontologies - Pathways
QuickGOP48728
Ontology : AmiGOaminomethyltransferase activity  aminomethyltransferase activity  nucleoplasm  mitochondrion  mitochondrion  mitochondrial matrix  glycine catabolic process  transaminase activity  glycine decarboxylation via glycine cleavage system  methylation  glyoxylate metabolic process  
Ontology : EGO-EBIaminomethyltransferase activity  aminomethyltransferase activity  nucleoplasm  mitochondrion  mitochondrion  mitochondrial matrix  glycine catabolic process  transaminase activity  glycine decarboxylation via glycine cleavage system  methylation  glyoxylate metabolic process  
Pathways : KEGGGlycine, serine and threonine metabolism    One carbon pool by folate   
NDEx NetworkAMT
Atlas of Cancer Signalling NetworkAMT
Wikipedia pathwaysAMT
Orthology - Evolution
OrthoDB275
GeneTree (enSembl)ENSG00000145020
Phylogenetic Trees/Animal Genes : TreeFamAMT
HOVERGENP48728
HOGENOMP48728
Homologs : HomoloGeneAMT
Homology/Alignments : Family Browser (UCSC)AMT
Gene fusions - Rearrangements
Tumor Fusion PortalAMT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAMT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AMT
dbVarAMT
ClinVarAMT
1000_GenomesAMT 
Exome Variant ServerAMT
ExAC (Exome Aggregation Consortium)ENSG00000145020
GNOMAD BrowserENSG00000145020
Genetic variants : HAPMAP275
Genomic Variants (DGV)AMT [DGVbeta]
DECIPHERAMT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAMT 
Mutations
ICGC Data PortalAMT 
TCGA Data PortalAMT 
Broad Tumor PortalAMT
OASIS PortalAMT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAMT  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAMT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch AMT
DgiDB (Drug Gene Interaction Database)AMT
DoCM (Curated mutations)AMT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AMT (select a term)
intoGenAMT
Cancer3DAMT(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM238310    605899   
Orphanet20768    20766    20767   
DisGeNETAMT
MedgenAMT
Genetic Testing Registry AMT
NextProtP48728 [Medical]
TSGene275
GENETestsAMT
Target ValidationAMT
Huge Navigator AMT [HugePedia]
snp3D : Map Gene to Disease275
BioCentury BCIQAMT
ClinGenAMT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD275
Chemical/Pharm GKB GenePA24780
Clinical trialAMT
Miscellaneous
canSAR (ICR)AMT (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAMT
EVEXAMT
GoPubMedAMT
iHOPAMT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:06:57 CET 2017

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