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ANAPC1 (anaphase promoting complex subunit 1)

Identity

Alias (NCBI)APC1
MCPR
TSG24
HGNC (Hugo) ANAPC1
HGNC Alias symbMCPR
TSG24
APC1
LocusID (NCBI) 64682
Atlas_Id 47289
Location 2q13  [Link to chromosome band 2q13]
Location_base_pair Starts at 111767640 and ends at 111884193 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANAPC1 (2q13) / CLK1 (2q33.1)ANAPC1 (2q13) / PSMB7 (9q33.3)ANAPC1 (2q13) / RGPD3 (2q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ANAPC1   19988
Cards
Entrez_Gene (NCBI)ANAPC1    anaphase promoting complex subunit 1
AliasesAPC1; MCPR; TSG24
GeneCards (Weizmann)ANAPC1
Ensembl hg19 (Hinxton)ENSG00000153107 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153107 [Gene_View]  ENSG00000153107 [Sequence]  chr2:111767640-111884193 [Contig_View]  ANAPC1 [Vega]
ICGC DataPortalENSG00000153107
TCGA cBioPortalANAPC1
AceView (NCBI)ANAPC1
Genatlas (Paris)ANAPC1
SOURCE (Princeton)ANAPC1
Genetics Home Reference (NIH)ANAPC1
Genomic and cartography
GoldenPath hg38 (UCSC)ANAPC1  -     chr2:111767640-111884193 -  2q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANAPC1  -     2q13   [Description]    (hg19-Feb_2009)
GoldenPathANAPC1 - 2q13 [CytoView hg19]  ANAPC1 - 2q13 [CytoView hg38]
ImmunoBaseENSG00000153107
Genome Data Viewer NCBIANAPC1 [Mapview hg19]  
OMIM608473   618625   
Gene and transcription
Genbank (Entrez)AI421643 AJ278357 AK023807 AK094527 AL832013
RefSeq transcript (Entrez)NM_022662
Consensus coding sequences : CCDS (NCBI)ANAPC1
Gene ExpressionANAPC1 [ NCBI-GEO ]   ANAPC1 [ EBI - ARRAY_EXPRESS ]   ANAPC1 [ SEEK ]   ANAPC1 [ MEM ]
Gene Expression Viewer (FireBrowse)ANAPC1 [ Firebrowse - Broad ]
GenevisibleExpression of ANAPC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64682
GTEX Portal (Tissue expression)ANAPC1
Human Protein AtlasENSG00000153107-ANAPC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H1A4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H1A4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H1A4
PhosPhoSitePlusQ9H1A4
Domains : Interpro (EBI)Apc1    APC1_C   
Domain families : Pfam (Sanger)ANAPC1 (PF12859)    APC1_C (PF18122)   
Domain families : Pfam (NCBI)pfam12859    pfam18122   
Conserved Domain (NCBI)ANAPC1
PDB (RSDB)4UI9    5A31    5G04    5G05    5KHR    5KHU    5L9T    5L9U    5LCW    5LGG    6Q6G    6Q6H    6TLJ    6TM5   
PDB Europe4UI9    5A31    5G04    5G05    5KHR    5KHU    5L9T    5L9U    5LCW    5LGG    6Q6G    6Q6H    6TLJ    6TM5   
PDB (PDBSum)4UI9    5A31    5G04    5G05    5KHR    5KHU    5L9T    5L9U    5LCW    5LGG    6Q6G    6Q6H    6TLJ    6TM5   
PDB (IMB)4UI9    5A31    5G04    5G05    5KHR    5KHU    5L9T    5L9U    5LCW    5LGG    6Q6G    6Q6H    6TLJ    6TM5   
Structural Biology KnowledgeBase4UI9    5A31    5G04    5G05    5KHR    5KHU    5L9T    5L9U    5LCW    5LGG    6Q6G    6Q6H    6TLJ    6TM5   
SCOP (Structural Classification of Proteins)4UI9    5A31    5G04    5G05    5KHR    5KHU    5L9T    5L9U    5LCW    5LGG    6Q6G    6Q6H    6TLJ    6TM5   
CATH (Classification of proteins structures)4UI9    5A31    5G04    5G05    5KHR    5KHU    5L9T    5L9U    5LCW    5LGG    6Q6G    6Q6H    6TLJ    6TM5   
SuperfamilyQ9H1A4
AlphaFold pdb e-kbQ9H1A4   
Human Protein Atlas [tissue]ENSG00000153107-ANAPC1 [tissue]
HPRD09769
Protein Interaction databases
DIP (DOE-UCLA)Q9H1A4
IntAct (EBI)Q9H1A4
BioGRIDANAPC1
STRING (EMBL)ANAPC1
ZODIACANAPC1
Ontologies - Pathways
QuickGOQ9H1A4
Ontology : AmiGOnucleoplasm  anaphase-promoting complex  anaphase-promoting complex  cytosol  ubiquitin-dependent protein catabolic process  metaphase/anaphase transition of mitotic cell cycle  regulation of exit from mitosis  anaphase-promoting complex-dependent catabolic process  anaphase-promoting complex-dependent catabolic process  cell division  molecular adaptor activity  protein K11-linked ubiquitination  protein K11-linked ubiquitination  regulation of mitotic cell cycle phase transition  
Ontology : EGO-EBInucleoplasm  anaphase-promoting complex  anaphase-promoting complex  cytosol  ubiquitin-dependent protein catabolic process  metaphase/anaphase transition of mitotic cell cycle  regulation of exit from mitosis  anaphase-promoting complex-dependent catabolic process  anaphase-promoting complex-dependent catabolic process  cell division  molecular adaptor activity  protein K11-linked ubiquitination  protein K11-linked ubiquitination  regulation of mitotic cell cycle phase transition  
Pathways : KEGGCell cycle    Oocyte meiosis    Ubiquitin mediated proteolysis    Progesterone-mediated oocyte maturation    HTLV-I infection   
NDEx NetworkANAPC1
Atlas of Cancer Signalling NetworkANAPC1
Wikipedia pathwaysANAPC1
Orthology - Evolution
OrthoDB64682
GeneTree (enSembl)ENSG00000153107
Phylogenetic Trees/Animal Genes : TreeFamANAPC1
Homologs : HomoloGeneANAPC1
Homology/Alignments : Family Browser (UCSC)ANAPC1
Gene fusions - Rearrangements
Fusion : MitelmanANAPC1/RGPD3 [2q13/2q12.2]  
Fusion : QuiverANAPC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANAPC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANAPC1
dbVarANAPC1
ClinVarANAPC1
MonarchANAPC1
1000_GenomesANAPC1 
Exome Variant ServerANAPC1
GNOMAD BrowserENSG00000153107
Varsome BrowserANAPC1
ACMGANAPC1 variants
VarityQ9H1A4
Genomic Variants (DGV)ANAPC1 [DGVbeta]
DECIPHERANAPC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANAPC1 
Mutations
ICGC Data PortalANAPC1 
TCGA Data PortalANAPC1 
Broad Tumor PortalANAPC1
OASIS PortalANAPC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANAPC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DANAPC1
Mutations and Diseases : HGMDANAPC1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaANAPC1
DgiDB (Drug Gene Interaction Database)ANAPC1
DoCM (Curated mutations)ANAPC1
CIViC (Clinical Interpretations of Variants in Cancer)ANAPC1
Cancer3DANAPC1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608473    618625   
Orphanet
DisGeNETANAPC1
MedgenANAPC1
Genetic Testing Registry ANAPC1
NextProtQ9H1A4 [Medical]
GENETestsANAPC1
Target ValidationANAPC1
Huge Navigator ANAPC1 [HugePedia]
ClinGenANAPC1
Clinical trials, drugs, therapy
MyCancerGenomeANAPC1
Protein Interactions : CTDANAPC1
Pharm GKB GenePA134907013
PharosQ9H1A4
Clinical trialANAPC1
Miscellaneous
canSAR (ICR)ANAPC1
HarmonizomeANAPC1
DataMed IndexANAPC1
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXANAPC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:59:17 CEST 2021

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