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ANAPC2 (anaphase promoting complex subunit 2)

Identity

Alias_symbol (synonym)APC2
KIAA1406
Other alias
HGNC (Hugo) ANAPC2
LocusID (NCBI) 29882
Atlas_Id 52422
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 137174784 and ends at 137188605 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
S100A6 (1q21.3) / ANAPC2 (9q34.3)ZMIZ1 (10q22.3) / ANAPC2 (9q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ANAPC2   19989
Cards
Entrez_Gene (NCBI)ANAPC2  29882  anaphase promoting complex subunit 2
AliasesAPC2
GeneCards (Weizmann)ANAPC2
Ensembl hg19 (Hinxton)ENSG00000176248 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176248 [Gene_View]  chr9:137174784-137188605 [Contig_View]  ANAPC2 [Vega]
ICGC DataPortalENSG00000176248
TCGA cBioPortalANAPC2
AceView (NCBI)ANAPC2
Genatlas (Paris)ANAPC2
WikiGenes29882
SOURCE (Princeton)ANAPC2
Genetics Home Reference (NIH)ANAPC2
Genomic and cartography
GoldenPath hg38 (UCSC)ANAPC2  -     chr9:137174784-137188605 -  9q34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANAPC2  -     9q34.3   [Description]    (hg19-Feb_2009)
EnsemblANAPC2 - 9q34.3 [CytoView hg19]  ANAPC2 - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBIANAPC2 [Mapview hg19]  ANAPC2 [Mapview hg38]
OMIM606946   
Gene and transcription
Genbank (Entrez)AB037827 AF191337 AK294601 AK296204 BC001579
RefSeq transcript (Entrez)NM_013366
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANAPC2
Cluster EST : UnigeneHs.533262 [ NCBI ]
CGAP (NCI)Hs.533262
Alternative Splicing GalleryENSG00000176248
Gene ExpressionANAPC2 [ NCBI-GEO ]   ANAPC2 [ EBI - ARRAY_EXPRESS ]   ANAPC2 [ SEEK ]   ANAPC2 [ MEM ]
Gene Expression Viewer (FireBrowse)ANAPC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29882
GTEX Portal (Tissue expression)ANAPC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJX6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJX6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJX6
Splice isoforms : SwissVarQ9UJX6
PhosPhoSitePlusQ9UJX6
Domaine pattern : Prosite (Expaxy)CULLIN_2 (PS50069)   
Domains : Interpro (EBI)APC_su2_C    Cullin_homology    Cullin_N    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)ANAPC2 (PF08672)    Cullin (PF00888)   
Domain families : Pfam (NCBI)pfam08672    pfam00888   
Domain families : Smart (EMBL)APC2 (SM01013)  CULLIN (SM00182)  
Conserved Domain (NCBI)ANAPC2
DMDM Disease mutations29882
Blocks (Seattle)ANAPC2
PDB (SRS)4UI9    4YII    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
PDB (PDBSum)4UI9    4YII    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
PDB (IMB)4UI9    4YII    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
PDB (RSDB)4UI9    4YII    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
Structural Biology KnowledgeBase4UI9    4YII    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
SCOP (Structural Classification of Proteins)4UI9    4YII    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
CATH (Classification of proteins structures)4UI9    4YII    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
SuperfamilyQ9UJX6
Human Protein AtlasENSG00000176248
Peptide AtlasQ9UJX6
HPRD07367
IPIIPI00002549   IPI00375832   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJX6
IntAct (EBI)Q9UJX6
FunCoupENSG00000176248
BioGRIDANAPC2
STRING (EMBL)ANAPC2
ZODIACANAPC2
Ontologies - Pathways
QuickGOQ9UJX6
Ontology : AmiGOnucleoplasm  anaphase-promoting complex  cytosol  anaphase-promoting complex-dependent catabolic process  ubiquitin protein ligase binding  positive regulation of synaptic plasticity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of axon extension  positive regulation of dendrite morphogenesis  cell division  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  ubiquitin protein ligase activity  protein K11-linked ubiquitination  positive regulation of synapse maturation  
Ontology : EGO-EBInucleoplasm  anaphase-promoting complex  cytosol  anaphase-promoting complex-dependent catabolic process  ubiquitin protein ligase binding  positive regulation of synaptic plasticity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of axon extension  positive regulation of dendrite morphogenesis  cell division  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  ubiquitin protein ligase activity  protein K11-linked ubiquitination  positive regulation of synapse maturation  
Pathways : KEGGCell cycle    Oocyte meiosis    Ubiquitin mediated proteolysis    Progesterone-mediated oocyte maturation    HTLV-I infection   
NDEx NetworkANAPC2
Atlas of Cancer Signalling NetworkANAPC2
Wikipedia pathwaysANAPC2
Orthology - Evolution
OrthoDB29882
GeneTree (enSembl)ENSG00000176248
Phylogenetic Trees/Animal Genes : TreeFamANAPC2
HOVERGENQ9UJX6
HOGENOMQ9UJX6
Homologs : HomoloGeneANAPC2
Homology/Alignments : Family Browser (UCSC)ANAPC2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANAPC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANAPC2
dbVarANAPC2
ClinVarANAPC2
1000_GenomesANAPC2 
Exome Variant ServerANAPC2
ExAC (Exome Aggregation Consortium)ANAPC2 (select the gene name)
Genetic variants : HAPMAP29882
Genomic Variants (DGV)ANAPC2 [DGVbeta]
DECIPHERANAPC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANAPC2 
Mutations
ICGC Data PortalANAPC2 
TCGA Data PortalANAPC2 
Broad Tumor PortalANAPC2
OASIS PortalANAPC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANAPC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANAPC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANAPC2
DgiDB (Drug Gene Interaction Database)ANAPC2
DoCM (Curated mutations)ANAPC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANAPC2 (select a term)
intoGenANAPC2
Cancer3DANAPC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606946   
Orphanet
MedgenANAPC2
Genetic Testing Registry ANAPC2
NextProtQ9UJX6 [Medical]
TSGene29882
GENETestsANAPC2
Target ValidationANAPC2
Huge Navigator ANAPC2 [HugePedia]
snp3D : Map Gene to Disease29882
BioCentury BCIQANAPC2
ClinGenANAPC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29882
Chemical/Pharm GKB GenePA134884359
Clinical trialANAPC2
Miscellaneous
canSAR (ICR)ANAPC2 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANAPC2
EVEXANAPC2
GoPubMedANAPC2
iHOPANAPC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:57:09 CEST 2017

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