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ANAPC4 (anaphase promoting complex subunit 4)

Identity

Alias_symbol (synonym)APC4
Other alias
HGNC (Hugo) ANAPC4
LocusID (NCBI) 29945
Atlas_Id 60292
Location 4p15.2  [Link to chromosome band 4p15]
Location_base_pair Starts at 25378848 and ends at 25420120 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANAPC4 (4p15.2) / RTN4 (2p16.1)RTN4 (2p16.1) / ANAPC4 (4p15.2)TBC1D19 (4p15.2) / ANAPC4 (4p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ANAPC4   19990
Cards
Entrez_Gene (NCBI)ANAPC4  29945  anaphase promoting complex subunit 4
AliasesAPC4
GeneCards (Weizmann)ANAPC4
Ensembl hg19 (Hinxton)ENSG00000053900 [Gene_View]  chr4:25378848-25420120 [Contig_View]  ANAPC4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000053900 [Gene_View]  chr4:25378848-25420120 [Contig_View]  ANAPC4 [Vega]
ICGC DataPortalENSG00000053900
TCGA cBioPortalANAPC4
AceView (NCBI)ANAPC4
Genatlas (Paris)ANAPC4
WikiGenes29945
SOURCE (Princeton)ANAPC4
Genetics Home Reference (NIH)ANAPC4
Genomic and cartography
GoldenPath hg19 (UCSC)ANAPC4  -     chr4:25378848-25420120 +  4p15.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ANAPC4  -     4p15.2   [Description]    (hg38-Dec_2013)
EnsemblANAPC4 - 4p15.2 [CytoView hg19]  ANAPC4 - 4p15.2 [CytoView hg38]
Mapping of homologs : NCBIANAPC4 [Mapview hg19]  ANAPC4 [Mapview hg38]
OMIM606947   
Gene and transcription
Genbank (Entrez)AF191338 AK001881 AK023562 AK023597 AK292336
RefSeq transcript (Entrez)NM_001286756 NM_013367
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_006316 NW_004929315
Consensus coding sequences : CCDS (NCBI)ANAPC4
Cluster EST : UnigeneHs.152173 [ NCBI ]
CGAP (NCI)Hs.152173
Alternative Splicing GalleryENSG00000053900
Gene ExpressionANAPC4 [ NCBI-GEO ]   ANAPC4 [ EBI - ARRAY_EXPRESS ]   ANAPC4 [ SEEK ]   ANAPC4 [ MEM ]
Gene Expression Viewer (FireBrowse)ANAPC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29945
GTEX Portal (Tissue expression)ANAPC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJX5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJX5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJX5
Splice isoforms : SwissVarQ9UJX5
PhosPhoSitePlusQ9UJX5
Domains : Interpro (EBI)APC4    APC4_long_dom    APC4_metazoa    Apc4_WD40_dom    WD40/YVTN_repeat-like_dom    WD40_repeat_dom   
Domain families : Pfam (Sanger)Apc4 (PF12896)    Apc4_WD40 (PF12894)   
Domain families : Pfam (NCBI)pfam12896    pfam12894   
Conserved Domain (NCBI)ANAPC4
DMDM Disease mutations29945
Blocks (Seattle)ANAPC4
SuperfamilyQ9UJX5
Human Protein AtlasENSG00000053900
Peptide AtlasQ9UJX5
HPRD09505
IPIIPI00002551   IPI00419201   IPI00966303   IPI00969130   IPI00966626   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJX5
IntAct (EBI)Q9UJX5
FunCoupENSG00000053900
BioGRIDANAPC4
STRING (EMBL)ANAPC4
ZODIACANAPC4
Ontologies - Pathways
QuickGOQ9UJX5
Ontology : AmiGOmitotic cell cycle  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  anaphase-promoting complex  cytosol  mitotic nuclear division  mitotic spindle assembly checkpoint  protein phosphatase binding  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  cell division  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  protein K11-linked ubiquitination  
Ontology : EGO-EBImitotic cell cycle  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  anaphase-promoting complex  cytosol  mitotic nuclear division  mitotic spindle assembly checkpoint  protein phosphatase binding  anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  cell division  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  protein K11-linked ubiquitination  
Pathways : KEGGCell cycle    Oocyte meiosis    Ubiquitin mediated proteolysis    Progesterone-mediated oocyte maturation    HTLV-I infection   
NDEx NetworkANAPC4
Atlas of Cancer Signalling NetworkANAPC4
Wikipedia pathwaysANAPC4
Orthology - Evolution
OrthoDB29945
GeneTree (enSembl)ENSG00000053900
Phylogenetic Trees/Animal Genes : TreeFamANAPC4
HOVERGENQ9UJX5
HOGENOMQ9UJX5
Homologs : HomoloGeneANAPC4
Homology/Alignments : Family Browser (UCSC)ANAPC4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANAPC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANAPC4
dbVarANAPC4
ClinVarANAPC4
1000_GenomesANAPC4 
Exome Variant ServerANAPC4
ExAC (Exome Aggregation Consortium)ANAPC4 (select the gene name)
Genetic variants : HAPMAP29945
Genomic Variants (DGV)ANAPC4 [DGVbeta]
DECIPHER (Syndromes)4:25378848-25420120  ENSG00000053900
CONAN: Copy Number AnalysisANAPC4 
Mutations
ICGC Data PortalANAPC4 
TCGA Data PortalANAPC4 
Broad Tumor PortalANAPC4
OASIS PortalANAPC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANAPC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANAPC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANAPC4
DgiDB (Drug Gene Interaction Database)ANAPC4
DoCM (Curated mutations)ANAPC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANAPC4 (select a term)
intoGenANAPC4
Cancer3DANAPC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606947   
Orphanet
MedgenANAPC4
Genetic Testing Registry ANAPC4
NextProtQ9UJX5 [Medical]
TSGene29945
GENETestsANAPC4
Huge Navigator ANAPC4 [HugePedia]
snp3D : Map Gene to Disease29945
BioCentury BCIQANAPC4
ClinGenANAPC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29945
Chemical/Pharm GKB GenePA134894250
Clinical trialANAPC4
Miscellaneous
canSAR (ICR)ANAPC4 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANAPC4
EVEXANAPC4
GoPubMedANAPC4
iHOPANAPC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 11:54:15 CET 2017

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