ANAPC5 (anaphase promoting complex subunit 5)

2007-04-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
APC5
FUSION GENES

Other Information

Locus ID:

NCBI: 51433
MIM: 606948
HGNC: 15713
Ensembl: ENSG00000089053

Variants:

dbSNP: 51433
ClinVar: 51433
TCGA: ENSG00000089053
COSMIC: ANAPC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089053ENST00000261819Q9UJX4
ENSG00000089053ENST00000441917Q9UJX4
ENSG00000089053ENST00000535482F5H0N1
ENSG00000089053ENST00000536837F5GZ05
ENSG00000089053ENST00000539079H0YFB5
ENSG00000089053ENST00000539871F5H3S5
ENSG00000089053ENST00000541887F5H0F9
ENSG00000089053ENST00000544442F5GY68

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Ubiquitin mediated proteolysisKEGGko04120
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
Ubiquitin mediated proteolysisKEGGhsa04120
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
APC/C complexKEGGhsa_M00389
APC/C complexKEGGM00389
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
Mitotic Spindle CheckpointREACTOMER-HSA-69618
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsREACTOMER-HSA-141405
Inactivation of APC/C via direct inhibition of the APC/C complexREACTOMER-HSA-141430
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176814
Phosphorylation of the APC/CREACTOMER-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointREACTOMER-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin AREACTOMER-HSA-174184
APC-Cdc20 mediated degradation of Nek2AREACTOMER-HSA-179409
APC/C:Cdc20 mediated degradation of Cyclin BREACTOMER-HSA-174048
APC/C:Cdc20 mediated degradation of SecurinREACTOMER-HSA-174154
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseREACTOMER-HSA-176407
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1REACTOMER-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/CREACTOMER-HSA-174084
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198264162010The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression.48
163198952005The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.44
206860302010Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.21
287311772017Co‑expression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway.6
150827552004The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation.5

Citation

Dessen P

ANAPC5 (anaphase promoting complex subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47449/anapc5