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ANAPC5 (anaphase promoting complex subunit 5)

Identity

Alias_symbol (synonym)APC5
Other alias
HGNC (Hugo) ANAPC5
LocusID (NCBI) 51433
Atlas_Id 47449
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 121308245 and ends at 121354209 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANAPC5 (12q24.31) / ACYP2 (2p16.2)ANAPC5 (12q24.31) / ANAPC5 (12q24.31)ANAPC5 (12q24.31) / G6PD (Xq28)
ANAPC5 (12q24.31) / KDM2B (12q24.31)ANAPC5 12q24.31 / KDM2B 12q24.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ANAPC5   15713
Cards
Entrez_Gene (NCBI)ANAPC5  51433  anaphase promoting complex subunit 5
AliasesAPC5
GeneCards (Weizmann)ANAPC5
Ensembl hg19 (Hinxton)ENSG00000089053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089053 [Gene_View]  chr12:121308245-121354209 [Contig_View]  ANAPC5 [Vega]
ICGC DataPortalENSG00000089053
TCGA cBioPortalANAPC5
AceView (NCBI)ANAPC5
Genatlas (Paris)ANAPC5
WikiGenes51433
SOURCE (Princeton)ANAPC5
Genetics Home Reference (NIH)ANAPC5
Genomic and cartography
GoldenPath hg38 (UCSC)ANAPC5  -     chr12:121308245-121354209 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANAPC5  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblANAPC5 - 12q24.31 [CytoView hg19]  ANAPC5 - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBIANAPC5 [Mapview hg19]  ANAPC5 [Mapview hg38]
OMIM606948   
Gene and transcription
Genbank (Entrez)AA349724 AF191339 AI879332 AK025614 AK054779
RefSeq transcript (Entrez)NM_001137559 NM_001330489 NM_016237
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANAPC5
Cluster EST : UnigeneHs.7101 [ NCBI ]
CGAP (NCI)Hs.7101
Alternative Splicing GalleryENSG00000089053
Gene ExpressionANAPC5 [ NCBI-GEO ]   ANAPC5 [ EBI - ARRAY_EXPRESS ]   ANAPC5 [ SEEK ]   ANAPC5 [ MEM ]
Gene Expression Viewer (FireBrowse)ANAPC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51433
GTEX Portal (Tissue expression)ANAPC5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJX4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJX4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJX4
Splice isoforms : SwissVarQ9UJX4
PhosPhoSitePlusQ9UJX4
Domains : Interpro (EBI)Apc5_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)ANAPC5 (PF12862)   
Domain families : Pfam (NCBI)pfam12862   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)ANAPC5
DMDM Disease mutations51433
Blocks (Seattle)ANAPC5
PDB (SRS)4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
PDB (PDBSum)4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
PDB (IMB)4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
PDB (RSDB)4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
Structural Biology KnowledgeBase4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
SCOP (Structural Classification of Proteins)4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
CATH (Classification of proteins structures)4UI9    5A31    5G04    5G05    5KHR    5L9T    5L9U    5LCW   
SuperfamilyQ9UJX4
Human Protein AtlasENSG00000089053
Peptide AtlasQ9UJX4
HPRD10453
IPIIPI00008247   IPI00375602   IPI00383638   IPI01011593   IPI00788662   IPI01010709   IPI00798336   IPI01016032   IPI01009549   IPI01014487   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJX4
IntAct (EBI)Q9UJX4
FunCoupENSG00000089053
BioGRIDANAPC5
STRING (EMBL)ANAPC5
ZODIACANAPC5
Ontologies - Pathways
QuickGOQ9UJX4
Ontology : AmiGOnucleus  nucleoplasm  anaphase-promoting complex  cytosol  protein phosphatase binding  anaphase-promoting complex-dependent catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  cell division  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  protein K11-linked ubiquitination  
Ontology : EGO-EBInucleus  nucleoplasm  anaphase-promoting complex  cytosol  protein phosphatase binding  anaphase-promoting complex-dependent catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  cell division  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  protein K11-linked ubiquitination  
Pathways : KEGGCell cycle    Oocyte meiosis    Ubiquitin mediated proteolysis    Progesterone-mediated oocyte maturation    HTLV-I infection   
NDEx NetworkANAPC5
Atlas of Cancer Signalling NetworkANAPC5
Wikipedia pathwaysANAPC5
Orthology - Evolution
OrthoDB51433
GeneTree (enSembl)ENSG00000089053
Phylogenetic Trees/Animal Genes : TreeFamANAPC5
HOVERGENQ9UJX4
HOGENOMQ9UJX4
Homologs : HomoloGeneANAPC5
Homology/Alignments : Family Browser (UCSC)ANAPC5
Gene fusions - Rearrangements
Fusion : MitelmanANAPC5/KDM2B [12q24.31/12q24.31]  
Fusion: TCGAANAPC5 12q24.31 KDM2B 12q24.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANAPC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANAPC5
dbVarANAPC5
ClinVarANAPC5
1000_GenomesANAPC5 
Exome Variant ServerANAPC5
ExAC (Exome Aggregation Consortium)ANAPC5 (select the gene name)
Genetic variants : HAPMAP51433
Genomic Variants (DGV)ANAPC5 [DGVbeta]
DECIPHERANAPC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANAPC5 
Mutations
ICGC Data PortalANAPC5 
TCGA Data PortalANAPC5 
Broad Tumor PortalANAPC5
OASIS PortalANAPC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANAPC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANAPC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANAPC5
DgiDB (Drug Gene Interaction Database)ANAPC5
DoCM (Curated mutations)ANAPC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANAPC5 (select a term)
intoGenANAPC5
Cancer3DANAPC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606948   
Orphanet
MedgenANAPC5
Genetic Testing Registry ANAPC5
NextProtQ9UJX4 [Medical]
TSGene51433
GENETestsANAPC5
Huge Navigator ANAPC5 [HugePedia]
snp3D : Map Gene to Disease51433
BioCentury BCIQANAPC5
ClinGenANAPC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51433
Chemical/Pharm GKB GenePA24788
Clinical trialANAPC5
Miscellaneous
canSAR (ICR)ANAPC5 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANAPC5
EVEXANAPC5
GoPubMedANAPC5
iHOPANAPC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:05:54 CEST 2017

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