Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ANGPT1 (angiopoietin 1)

Identity

Alias_symbol (synonym)KIAA0003
Ang1
Other aliasAGP1
AGPT
ANG1
HGNC (Hugo) ANGPT1
LocusID (NCBI) 284
Atlas_Id 636
Location 8q23.1  [Link to chromosome band 8q23]
Location_base_pair Starts at 107249482 and ends at 107498055 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANGPT1 (8q23.1) / CXCL12 (10q11.21)ANGPT1 (8q23.1) / HIP1 (7q11.23)CSMD3 (8q23.3) / ANGPT1 (8q23.1)
ZFP41 (8q24.3) / ANGPT1 (8q23.1)ZFP41 8q24.3 / ANGPT1 8q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)ANGPT1   484
Cards
Entrez_Gene (NCBI)ANGPT1  284  angiopoietin 1
AliasesAGP1; AGPT; ANG1
GeneCards (Weizmann)ANGPT1
Ensembl hg19 (Hinxton)ENSG00000154188 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154188 [Gene_View]  chr8:107249482-107498055 [Contig_View]  ANGPT1 [Vega]
ICGC DataPortalENSG00000154188
TCGA cBioPortalANGPT1
AceView (NCBI)ANGPT1
Genatlas (Paris)ANGPT1
WikiGenes284
SOURCE (Princeton)ANGPT1
Genetics Home Reference (NIH)ANGPT1
Genomic and cartography
GoldenPath hg38 (UCSC)ANGPT1  -     chr8:107249482-107498055 -  8q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANGPT1  -     8q23.1   [Description]    (hg19-Feb_2009)
EnsemblANGPT1 - 8q23.1 [CytoView hg19]  ANGPT1 - 8q23.1 [CytoView hg38]
Mapping of homologs : NCBIANGPT1 [Mapview hg19]  ANGPT1 [Mapview hg38]
OMIM601667   
Gene and transcription
Genbank (Entrez)AB084454 AK300319 AK304717 AL700429 AW069541
RefSeq transcript (Entrez)NM_001146 NM_001199859 NM_001314051 NM_139290
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANGPT1
Cluster EST : UnigeneHs.369675 [ NCBI ]
CGAP (NCI)Hs.369675
Alternative Splicing GalleryENSG00000154188
Gene ExpressionANGPT1 [ NCBI-GEO ]   ANGPT1 [ EBI - ARRAY_EXPRESS ]   ANGPT1 [ SEEK ]   ANGPT1 [ MEM ]
Gene Expression Viewer (FireBrowse)ANGPT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)284
GTEX Portal (Tissue expression)ANGPT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15389   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15389  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15389
Splice isoforms : SwissVarQ15389
PhosPhoSitePlusQ15389
Domaine pattern : Prosite (Expaxy)FIBRINOGEN_C_1 (PS00514)    FIBRINOGEN_C_2 (PS51406)   
Domains : Interpro (EBI)Ang-1    Fibrinogen_a/b/g_C_1    Fibrinogen_a/b/g_C_2    Fibrinogen_a/b/g_C_dom    Fibrinogen_CS   
Domain families : Pfam (Sanger)Fibrinogen_C (PF00147)   
Domain families : Pfam (NCBI)pfam00147   
Domain families : Smart (EMBL)FBG (SM00186)  
Conserved Domain (NCBI)ANGPT1
DMDM Disease mutations284
Blocks (Seattle)ANGPT1
PDB (SRS)4EPU    4JYO    4K0V   
PDB (PDBSum)4EPU    4JYO    4K0V   
PDB (IMB)4EPU    4JYO    4K0V   
PDB (RSDB)4EPU    4JYO    4K0V   
Structural Biology KnowledgeBase4EPU    4JYO    4K0V   
SCOP (Structural Classification of Proteins)4EPU    4JYO    4K0V   
CATH (Classification of proteins structures)4EPU    4JYO    4K0V   
SuperfamilyQ15389
Human Protein AtlasENSG00000154188
Peptide AtlasQ15389
HPRD03392
IPIIPI00016677   IPI00796953   IPI00789177   IPI00976582   IPI01013211   IPI01011803   
Protein Interaction databases
DIP (DOE-UCLA)Q15389
IntAct (EBI)Q15389
FunCoupENSG00000154188
BioGRIDANGPT1
STRING (EMBL)ANGPT1
ZODIACANGPT1
Ontologies - Pathways
QuickGOQ15389
Ontology : AmiGOMAPK cascade  in utero embryonic development  negative regulation of protein phosphorylation  regulation of endothelial cell proliferation  sprouting angiogenesis  positive regulation of receptor internalization  negative regulation of cytokine secretion involved in immune response  Ras guanyl-nucleotide exchange factor activity  extracellular region  extracellular space  intracellular  plasma membrane  microvillus  negative regulation of cell adhesion  activation of transmembrane receptor protein tyrosine kinase activity  positive regulation of endothelial cell migration  positive regulation of phosphatidylinositol 3-kinase signaling  regulation of skeletal muscle satellite cell proliferation  hemopoiesis  cell differentiation  heparin biosynthetic process  receptor tyrosine kinase binding  positive regulation of protein ubiquitination  cell-substrate adhesion  regulation of tumor necrosis factor production  positive regulation of peptidyl-serine phosphorylation  protein localization to cell surface  negative regulation of protein import into nucleus  negative regulation of apoptotic process  negative regulation of vascular permeability  regulation of I-kappaB kinase/NF-kappaB signaling  regulation of protein binding  negative regulation of neuron apoptotic process  positive regulation of blood vessel endothelial cell migration  positive regulation of GTPase activity  membrane raft  positive regulation of cell adhesion  Tie signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  positive chemotaxis  positive regulation of protein kinase B signaling  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  glomerulus vasculature development  negative regulation of endothelial cell apoptotic process  regulation of macrophage migration inhibitory factor signaling pathway  
Ontology : EGO-EBIMAPK cascade  in utero embryonic development  negative regulation of protein phosphorylation  regulation of endothelial cell proliferation  sprouting angiogenesis  positive regulation of receptor internalization  negative regulation of cytokine secretion involved in immune response  Ras guanyl-nucleotide exchange factor activity  extracellular region  extracellular space  intracellular  plasma membrane  microvillus  negative regulation of cell adhesion  activation of transmembrane receptor protein tyrosine kinase activity  positive regulation of endothelial cell migration  positive regulation of phosphatidylinositol 3-kinase signaling  regulation of skeletal muscle satellite cell proliferation  hemopoiesis  cell differentiation  heparin biosynthetic process  receptor tyrosine kinase binding  positive regulation of protein ubiquitination  cell-substrate adhesion  regulation of tumor necrosis factor production  positive regulation of peptidyl-serine phosphorylation  protein localization to cell surface  negative regulation of protein import into nucleus  negative regulation of apoptotic process  negative regulation of vascular permeability  regulation of I-kappaB kinase/NF-kappaB signaling  regulation of protein binding  negative regulation of neuron apoptotic process  positive regulation of blood vessel endothelial cell migration  positive regulation of GTPase activity  membrane raft  positive regulation of cell adhesion  Tie signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  positive chemotaxis  positive regulation of protein kinase B signaling  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  glomerulus vasculature development  negative regulation of endothelial cell apoptotic process  regulation of macrophage migration inhibitory factor signaling pathway  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    HIF-1 signaling pathway    PI3K-Akt signaling pathway    Rheumatoid arthritis   
NDEx NetworkANGPT1
Atlas of Cancer Signalling NetworkANGPT1
Wikipedia pathwaysANGPT1
Orthology - Evolution
OrthoDB284
GeneTree (enSembl)ENSG00000154188
Phylogenetic Trees/Animal Genes : TreeFamANGPT1
HOVERGENQ15389
HOGENOMQ15389
Homologs : HomoloGeneANGPT1
Homology/Alignments : Family Browser (UCSC)ANGPT1
Gene fusions - Rearrangements
Fusion : MitelmanANGPT1/CXCL12 [8q23.1/10q11.21]  
Fusion : MitelmanCSMD3/ANGPT1 [8q23.3/8q23.1]  [t(8;8)(q23;q23)]  
Fusion : MitelmanZFP41/ANGPT1 [8q24.3/8q23.1]  [t(8;8)(q23;q24)]  
Fusion: TCGAZFP41 8q24.3 ANGPT1 8q23.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANGPT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANGPT1
dbVarANGPT1
ClinVarANGPT1
1000_GenomesANGPT1 
Exome Variant ServerANGPT1
ExAC (Exome Aggregation Consortium)ANGPT1 (select the gene name)
Genetic variants : HAPMAP284
Genomic Variants (DGV)ANGPT1 [DGVbeta]
DECIPHERANGPT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANGPT1 
Mutations
ICGC Data PortalANGPT1 
TCGA Data PortalANGPT1 
Broad Tumor PortalANGPT1
OASIS PortalANGPT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANGPT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANGPT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANGPT1
DgiDB (Drug Gene Interaction Database)ANGPT1
DoCM (Curated mutations)ANGPT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANGPT1 (select a term)
intoGenANGPT1
Cancer3DANGPT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601667   
Orphanet
MedgenANGPT1
Genetic Testing Registry ANGPT1
NextProtQ15389 [Medical]
TSGene284
GENETestsANGPT1
Target ValidationANGPT1
Huge Navigator ANGPT1 [HugePedia]
snp3D : Map Gene to Disease284
BioCentury BCIQANGPT1
ClinGenANGPT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD284
Chemical/Pharm GKB GenePA24791
Clinical trialANGPT1
Miscellaneous
canSAR (ICR)ANGPT1 (select the gene name)
Probes
Litterature
PubMed262 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANGPT1
EVEXANGPT1
GoPubMedANGPT1
iHOPANGPT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 18:57:10 CEST 2017

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