Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ANGPT2 (angiopoietin 2)

Identity

Alias_symbol (synonym)Ang2
Other aliasAGPT2
ANG2
HGNC (Hugo) ANGPT2
LocusID (NCBI) 285
Atlas_Id 637
Location 8p23.1  [Link to chromosome band 8p23]
Location_base_pair Starts at 6499651 and ends at 6563263 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAK16 (8p12) / ANGPT2 (8p23.1)MAK16 8p12 / ANGPT2 8p23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]

Solid Tumors TT_t0808p12p23ID108044

External links

Nomenclature
HGNC (Hugo)ANGPT2   485
Cards
Entrez_Gene (NCBI)ANGPT2  285  angiopoietin 2
AliasesAGPT2; ANG2
GeneCards (Weizmann)ANGPT2
Ensembl hg19 (Hinxton)ENSG00000091879 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091879 [Gene_View]  ENSG00000091879 [Sequence]  chr8:6499651-6563263 [Contig_View]  ANGPT2 [Vega]
ICGC DataPortalENSG00000091879
TCGA cBioPortalANGPT2
AceView (NCBI)ANGPT2
Genatlas (Paris)ANGPT2
WikiGenes285
SOURCE (Princeton)ANGPT2
Genetics Home Reference (NIH)ANGPT2
Genomic and cartography
GoldenPath hg38 (UCSC)ANGPT2  -     chr8:6499651-6563263 -  8p23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANGPT2  -     8p23.1   [Description]    (hg19-Feb_2009)
GoldenPathANGPT2 - 8p23.1 [CytoView hg19]  ANGPT2 - 8p23.1 [CytoView hg38]
ImmunoBaseENSG00000091879
Mapping of homologs : NCBIANGPT2 [Mapview hg19]  ANGPT2 [Mapview hg38]
OMIM601922   
Gene and transcription
Genbank (Entrez)AB009865 AF004327 AF187858 AF218015 AJ289780
RefSeq transcript (Entrez)NM_001118887 NM_001118888 NM_001147
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANGPT2
Cluster EST : UnigeneHs.583870 [ NCBI ]
CGAP (NCI)Hs.583870
Alternative Splicing GalleryENSG00000091879
Gene ExpressionANGPT2 [ NCBI-GEO ]   ANGPT2 [ EBI - ARRAY_EXPRESS ]   ANGPT2 [ SEEK ]   ANGPT2 [ MEM ]
Gene Expression Viewer (FireBrowse)ANGPT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)285
GTEX Portal (Tissue expression)ANGPT2
Human Protein AtlasENSG00000091879-ANGPT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15123   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15123  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15123
Splice isoforms : SwissVarO15123
PhosPhoSitePlusO15123
Domaine pattern : Prosite (Expaxy)FIBRINOGEN_C_1 (PS00514)    FIBRINOGEN_C_2 (PS51406)   
Domains : Interpro (EBI)Ang-2    Fibrinogen-like_C    Fibrinogen_a/b/g_C_1    Fibrinogen_a/b/g_C_2    Fibrinogen_a/b/g_C_dom    Fibrinogen_CS   
Domain families : Pfam (Sanger)Fibrinogen_C (PF00147)   
Domain families : Pfam (NCBI)pfam00147   
Domain families : Smart (EMBL)FBG (SM00186)  
Conserved Domain (NCBI)ANGPT2
DMDM Disease mutations285
Blocks (Seattle)ANGPT2
PDB (RSDB)1Z3S    1Z3U    2GY7    4JZC    4ZFG   
PDB Europe1Z3S    1Z3U    2GY7    4JZC    4ZFG   
PDB (PDBSum)1Z3S    1Z3U    2GY7    4JZC    4ZFG   
PDB (IMB)1Z3S    1Z3U    2GY7    4JZC    4ZFG   
Structural Biology KnowledgeBase1Z3S    1Z3U    2GY7    4JZC    4ZFG   
SCOP (Structural Classification of Proteins)1Z3S    1Z3U    2GY7    4JZC    4ZFG   
CATH (Classification of proteins structures)1Z3S    1Z3U    2GY7    4JZC    4ZFG   
SuperfamilyO15123
Human Protein Atlas [tissue]ENSG00000091879-ANGPT2 [tissue]
Peptide AtlasO15123
HPRD03563
IPIIPI00005128   IPI00181100   IPI00793960   
Protein Interaction databases
DIP (DOE-UCLA)O15123
IntAct (EBI)O15123
FunCoupENSG00000091879
BioGRIDANGPT2
STRING (EMBL)ANGPT2
ZODIACANGPT2
Ontologies - Pathways
QuickGOO15123
Ontology : AmiGOangiogenesis  response to hypoxia  signaling receptor binding  protein binding  extracellular region  extracellular space  nucleus  plasma membrane  signal transduction  germ cell development  response to radiation  response to mechanical stimulus  response to glucose  negative regulation of cell-substrate adhesion  response to organic cyclic compound  response to activity  negative regulation of angiogenesis  receptor tyrosine kinase binding  animal organ regeneration  cell projection  negative regulation of blood vessel endothelial cell migration  positive regulation of angiogenesis  metal ion binding  Tie signaling pathway  leukocyte migration  negative regulation of positive chemotaxis  maternal process involved in female pregnancy  cellular response to growth factor stimulus  glomerulus vasculature development  
Ontology : EGO-EBIangiogenesis  response to hypoxia  signaling receptor binding  protein binding  extracellular region  extracellular space  nucleus  plasma membrane  signal transduction  germ cell development  response to radiation  response to mechanical stimulus  response to glucose  negative regulation of cell-substrate adhesion  response to organic cyclic compound  response to activity  negative regulation of angiogenesis  receptor tyrosine kinase binding  animal organ regeneration  cell projection  negative regulation of blood vessel endothelial cell migration  positive regulation of angiogenesis  metal ion binding  Tie signaling pathway  leukocyte migration  negative regulation of positive chemotaxis  maternal process involved in female pregnancy  cellular response to growth factor stimulus  glomerulus vasculature development  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    HIF-1 signaling pathway    PI3K-Akt signaling pathway   
NDEx NetworkANGPT2
Atlas of Cancer Signalling NetworkANGPT2
Wikipedia pathwaysANGPT2
Orthology - Evolution
OrthoDB285
GeneTree (enSembl)ENSG00000091879
Phylogenetic Trees/Animal Genes : TreeFamANGPT2
HOGENOMO15123
Homologs : HomoloGeneANGPT2
Homology/Alignments : Family Browser (UCSC)ANGPT2
Gene fusions - Rearrangements
Fusion : MitelmanMAK16/ANGPT2 [8p12/8p23.1]  [t(8;8)(p12;p23)]  
Fusion PortalMAK16 8p12 ANGPT2 8p23.1 BRCA
Fusion : QuiverANGPT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANGPT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANGPT2
dbVarANGPT2
ClinVarANGPT2
1000_GenomesANGPT2 
Exome Variant ServerANGPT2
ExAC (Exome Aggregation Consortium)ENSG00000091879
GNOMAD BrowserENSG00000091879
Varsome BrowserANGPT2
Genetic variants : HAPMAP285
Genomic Variants (DGV)ANGPT2 [DGVbeta]
DECIPHERANGPT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANGPT2 
Mutations
ICGC Data PortalANGPT2 
TCGA Data PortalANGPT2 
Broad Tumor PortalANGPT2
OASIS PortalANGPT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANGPT2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DANGPT2
Mutations and Diseases : HGMDANGPT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANGPT2
DgiDB (Drug Gene Interaction Database)ANGPT2
DoCM (Curated mutations)ANGPT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANGPT2 (select a term)
intoGenANGPT2
Cancer3DANGPT2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601922   
Orphanet
DisGeNETANGPT2
MedgenANGPT2
Genetic Testing Registry ANGPT2
NextProtO15123 [Medical]
TSGene285
GENETestsANGPT2
Target ValidationANGPT2
Huge Navigator ANGPT2 [HugePedia]
snp3D : Map Gene to Disease285
BioCentury BCIQANGPT2
ClinGenANGPT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD285
Chemical/Pharm GKB GenePA24792
Clinical trialANGPT2
Miscellaneous
canSAR (ICR)ANGPT2 (select the gene name)
DataMed IndexANGPT2
Probes
Litterature
PubMed421 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANGPT2
EVEXANGPT2
GoPubMedANGPT2
iHOPANGPT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 12 15:24:24 CEST 2019
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