Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ANGPT2 (angiopoietin 2)

Identity

Other namesAGPT2
ANG2
HGNC (Hugo) ANGPT2
LocusID (NCBI) 285
Location 8p23.1
Location_base_pair Starts at 6357175 and ends at 6420784 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ANGPT2   485
Cards
Entrez_Gene (NCBI)ANGPT2  285  angiopoietin 2
GeneCards (Weizmann)ANGPT2
Ensembl (Hinxton)ENSG00000091879 [Gene_View]  chr8:6357175-6420784 [Contig_View]  ANGPT2 [Vega]
ICGC DataPortalENSG00000091879
cBioPortalANGPT2
AceView (NCBI)ANGPT2
Genatlas (Paris)ANGPT2
WikiGenes285
SOURCE (Princeton)NM_001118887 NM_001118888 NM_001147
Genomic and cartography
GoldenPath (UCSC)ANGPT2  -  8p23.1   chr8:6357175-6420784 -  8p23.1   [Description]    (hg19-Feb_2009)
EnsemblANGPT2 - 8p23.1 [CytoView]
Mapping of homologs : NCBIANGPT2 [Mapview]
OMIM601922   
Gene and transcription
Genbank (Entrez)AB009865 AF004327 AF187858 AF218015 AJ289780
RefSeq transcript (Entrez)NM_001118887 NM_001118888 NM_001147
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_016619 NG_029483 NT_023736 NW_001839109 NW_004929335
Consensus coding sequences : CCDS (NCBI)ANGPT2
Cluster EST : UnigeneHs.583870 [ NCBI ]
CGAP (NCI)Hs.583870
Alternative Splicing : Fast-db (Paris)GSHG0029360
Alternative Splicing GalleryENSG00000091879
Gene ExpressionANGPT2 [ NCBI-GEO ]     ANGPT2 [ SEEK ]   ANGPT2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15123 (Uniprot)
NextProtO15123  [Medical]
With graphics : InterProO15123
Splice isoforms : SwissVarO15123 (Swissvar)
Domaine pattern : Prosite (Expaxy)FIBRINOGEN_C_1 (PS00514)    FIBRINOGEN_C_2 (PS51406)   
Domains : Interpro (EBI)Ang-2 [organisation]   Fibrinogen_a/b/g_C_1 [organisation]   Fibrinogen_a/b/g_C_2 [organisation]   Fibrinogen_a/b/g_C_dom [organisation]   Fibrinogen_CS [organisation]  
Related proteins : CluSTrO15123
Domain families : Pfam (Sanger)Fibrinogen_C (PF00147)   
Domain families : Pfam (NCBI)pfam00147   
Domain families : Smart (EMBL)FBG (SM00186)  
DMDM Disease mutations285
Blocks (Seattle)O15123
PDB (SRS)1Z3S    1Z3U    2GY7    4JZC   
PDB (PDBSum)1Z3S    1Z3U    2GY7    4JZC   
PDB (IMB)1Z3S    1Z3U    2GY7    4JZC   
PDB (RSDB)1Z3S    1Z3U    2GY7    4JZC   
Human Protein AtlasENSG00000091879 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO15123
HPRD03563
IPIIPI00005128   IPI00181100   IPI00793960   
Protein Interaction databases
DIP (DOE-UCLA)O15123
IntAct (EBI)O15123
FunCoupENSG00000091879
BioGRIDANGPT2
InParanoidO15123
Interologous Interaction database O15123
IntegromeDBANGPT2
STRING (EMBL)ANGPT2
Ontologies - Pathways
Ontology : AmiGOangiogenesis  response to hypoxia  receptor binding  protein binding  extracellular region  extracellular space  nucleus  plasma membrane  signal transduction  germ cell development  blood coagulation  response to radiation  response to mechanical stimulus  response to glucose  negative regulation of cell-substrate adhesion  response to organic cyclic compound  response to activity  negative regulation of angiogenesis  receptor tyrosine kinase binding  organ regeneration  cell projection  negative regulation of blood vessel endothelial cell migration  positive regulation of angiogenesis  metal ion binding  Tie signaling pathway  leukocyte migration  negative regulation of positive chemotaxis  maternal process involved in female pregnancy  cellular response to growth factor stimulus  glomerulus vasculature development  
Ontology : EGO-EBIangiogenesis  response to hypoxia  receptor binding  protein binding  extracellular region  extracellular space  nucleus  plasma membrane  signal transduction  germ cell development  blood coagulation  response to radiation  response to mechanical stimulus  response to glucose  negative regulation of cell-substrate adhesion  response to organic cyclic compound  response to activity  negative regulation of angiogenesis  receptor tyrosine kinase binding  organ regeneration  cell projection  negative regulation of blood vessel endothelial cell migration  positive regulation of angiogenesis  metal ion binding  Tie signaling pathway  leukocyte migration  negative regulation of positive chemotaxis  maternal process involved in female pregnancy  cellular response to growth factor stimulus  glomerulus vasculature development  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    HIF-1 signaling pathway    PI3K-Akt signaling pathway   
Protein Interaction DatabaseANGPT2
Wikipedia pathwaysANGPT2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ANGPT2
snp3D : Map Gene to Disease285
SNP (GeneSNP Utah)ANGPT2
SNP : HGBaseANGPT2
Genetic variants : HAPMAPANGPT2
Exome VariantANGPT2
1000_GenomesANGPT2 
ICGC programENSG00000091879 
Somatic Mutations in Cancer : COSMICANGPT2 
CONAN: Copy Number AnalysisANGPT2 
Mutations and Diseases : HGMDANGPT2
Genomic VariantsANGPT2  ANGPT2 [DGVbeta]
dbVarANGPT2
ClinVarANGPT2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601922   
MedgenANGPT2
GENETestsANGPT2
Disease Genetic AssociationANGPT2
Huge Navigator ANGPT2 [HugePedia]  ANGPT2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneANGPT2
Homology/Alignments : Family Browser (UCSC)ANGPT2
Phylogenetic Trees/Animal Genes : TreeFamANGPT2
Chemical/Protein Interactions : CTD285
Chemical/Pharm GKB GenePA24792
Clinical trialANGPT2
Cancer Resource (Charite)ENSG00000091879
Other databases
Probes
Litterature
PubMed289 Pubmed reference(s) in Entrez
CoreMineANGPT2
iHOPANGPT2
OncoSearchANGPT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:23:47 CEST 2014
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