ANGPT2 (angiopoietin 2)

2003-05-01  

Identity

HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
AGPT2,ANG2
FUSION GENES

Other Information

Locus ID:

NCBI: 285
MIM: 601922
HGNC: 485
Ensembl: ENSG00000091879

Variants:

dbSNP: 285
ClinVar: 285
TCGA: ENSG00000091879
COSMIC: ANGPT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091879ENST00000325203O15123
ENSG00000091879ENST00000338312O15123
ENSG00000091879ENST00000523120E7EVQ3
ENSG00000091879ENST00000629816O15123

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Tie2 SignalingREACTOMER-HSA-210993

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
149760562004The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies.206
164174072006Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans.186
225855762012Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling.140
189575362008Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria.128
192234732009Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.117
295088552018Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.115
155424342004Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.112
193005302009Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children.99
175137912007Expression of Tie-2 by human monocytes and their responses to angiopoietin-2.97
170308142006Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.88

Citation

Dessen P

ANGPT2 (angiopoietin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/637/angpt2