ANGPTL2 (angiopoietin like 2)

2003-11-01  

Identity

HGNC
ANGPTL2
LOCATION
9q33.3
LOCUSID
23452
ALIAS
ARP2,HARP

Other Information

Locus ID:

NCBI: 23452
MIM: 605001
HGNC: 490
Ensembl: ENSG00000136859

Variants:

dbSNP: 23452
ClinVar: 23452
TCGA: ENSG00000136859
COSMIC: ANGPTL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136859ENST00000373417Q9UKU9
ENSG00000136859ENST00000373425Q9UKU9
ENSG00000136859ENST00000373425A0A024R868

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
197234942009Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance.106
225563342012Macrophage-derived angiopoietin-like protein 2 accelerates development of abdominal aortic aneurysm.43
245266912014Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression.42
223451522012Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.40
244486472014The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5β1, p38 MAPK, and matrix metalloproteinases.38
233338012013Perivascular adipose tissue-secreted angiopoietin-like protein 2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury.33
203049622010Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis.32
229660882013Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama study.25
248996232014A motif in LILRB2 critical for Angptl2 binding and activation.25
185939052008Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer.21

Citation

Dessen P

ANGPTL2 (angiopoietin like 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/640/angptl2