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ANGPTL3 (angiopoietin-like 3)

Identity

Other namesANG-5
ANGPT5
ANL3
FHBL2
HGNC (Hugo) ANGPTL3
LocusID (NCBI) 27329
Atlas_Id 47315
Location 1p31.3
Location_base_pair Starts at 63063158 and ends at 63071976 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ANGPTL3   491
Cards
Entrez_Gene (NCBI)ANGPTL3  27329  angiopoietin-like 3
GeneCards (Weizmann)ANGPTL3
Ensembl hg19 (Hinxton)ENSG00000132855 [Gene_View]  chr1:63063158-63071976 [Contig_View]  ANGPTL3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000132855 [Gene_View]  chr1:63063158-63071976 [Contig_View]  ANGPTL3 [Vega]
ICGC DataPortalENSG00000132855
TCGA cBioPortalANGPTL3
AceView (NCBI)ANGPTL3
Genatlas (Paris)ANGPTL3
WikiGenes27329
SOURCE (Princeton)ANGPTL3
Genomic and cartography
GoldenPath hg19 (UCSC)ANGPTL3  -     chr1:63063158-63071976 +  1p31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ANGPTL3  -     1p31.3   [Description]    (hg38-Dec_2013)
EnsemblANGPTL3 - 1p31.3 [CytoView hg19]  ANGPTL3 - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBIANGPTL3 [Mapview hg19]  ANGPTL3 [Mapview hg38]
OMIM604774   605019   
Gene and transcription
Genbank (Entrez)AF152562 AK289426 AK315304 AY358273 BC007059
RefSeq transcript (Entrez)NM_014495
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_028169 NG_033073 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)ANGPTL3
Cluster EST : UnigeneHs.209153 [ NCBI ]
CGAP (NCI)Hs.209153
Alternative Splicing : Fast-db (Paris)GSHG0000575
Alternative Splicing GalleryENSG00000132855
Gene ExpressionANGPTL3 [ NCBI-GEO ]     ANGPTL3 [ SEEK ]   ANGPTL3 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5C1 (Uniprot)
NextProtQ9Y5C1  [Medical]
With graphics : InterProQ9Y5C1
Splice isoforms : SwissVarQ9Y5C1 (Swissvar)
Domaine pattern : Prosite (Expaxy)FIBRINOGEN_C_2 (PS51406)   
Domains : Interpro (EBI)Fibrinogen_a/b/g_C_1    Fibrinogen_a/b/g_C_2    Fibrinogen_a/b/g_C_dom   
Related proteins : CluSTrQ9Y5C1
Domain families : Pfam (Sanger)Fibrinogen_C (PF00147)   
Domain families : Pfam (NCBI)pfam00147   
Domain families : Smart (EMBL)FBG (SM00186)  
DMDM Disease mutations27329
Blocks (Seattle)Q9Y5C1
Human Protein AtlasENSG00000132855
Peptide AtlasQ9Y5C1
HPRD10381
IPIIPI00004957   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5C1
IntAct (EBI)Q9Y5C1
FunCoupENSG00000132855
BioGRIDANGPTL3
IntegromeDBANGPTL3
STRING (EMBL)ANGPTL3
Ontologies - Pathways
QuickGOQ9Y5C1
Ontology : AmiGOenzyme inhibitor activity  phospholipase inhibitor activity  integrin binding  extracellular space  glycerol metabolic process  fatty acid metabolic process  phospholipid metabolic process  cell-matrix adhesion  signal transduction  integrin-mediated signaling pathway  growth factor activity  cholesterol metabolic process  phospholipid catabolic process  cell surface  negative regulation of phospholipase activity  lipid storage  positive regulation of cell migration  cholesterol homeostasis  positive regulation of angiogenesis  artery morphogenesis  positive regulation of lipid catabolic process  negative regulation of lipoprotein lipase activity  lipid homeostasis  acylglycerol homeostasis  phospholipid homeostasis  triglyceride homeostasis  triglyceride homeostasis  
Ontology : EGO-EBIenzyme inhibitor activity  phospholipase inhibitor activity  integrin binding  extracellular space  glycerol metabolic process  fatty acid metabolic process  phospholipid metabolic process  cell-matrix adhesion  signal transduction  integrin-mediated signaling pathway  growth factor activity  cholesterol metabolic process  phospholipid catabolic process  cell surface  negative regulation of phospholipase activity  lipid storage  positive regulation of cell migration  cholesterol homeostasis  positive regulation of angiogenesis  artery morphogenesis  positive regulation of lipid catabolic process  negative regulation of lipoprotein lipase activity  lipid homeostasis  acylglycerol homeostasis  phospholipid homeostasis  triglyceride homeostasis  triglyceride homeostasis  
Protein Interaction DatabaseANGPTL3
DoCM (Curated mutations)ANGPTL3
Wikipedia pathwaysANGPTL3
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerANGPTL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANGPTL3
dbVarANGPTL3
ClinVarANGPTL3
1000_GenomesANGPTL3 
Exome Variant ServerANGPTL3
SNP (GeneSNP Utah)ANGPTL3
SNP : HGBaseANGPTL3
Genetic variants : HAPMAPANGPTL3
Genomic Variants (DGV)ANGPTL3 [DGVbeta]
Mutations
ICGC Data PortalANGPTL3 
TCGA Data PortalANGPTL3 
Tumor PortalANGPTL3
Somatic Mutations in Cancer : COSMICANGPTL3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:63063158-63071976
CONAN: Copy Number AnalysisANGPTL3 
Mutations and Diseases : HGMDANGPTL3
OMIM604774    605019   
MedgenANGPTL3
NextProtQ9Y5C1 [Medical]
GENETestsANGPTL3
Disease Genetic AssociationANGPTL3
Huge Navigator ANGPTL3 [HugePedia]  ANGPTL3 [HugeCancerGEM]
snp3D : Map Gene to Disease27329
DGIdb (Drug Gene Interaction db)ANGPTL3
General knowledge
Homologs : HomoloGeneANGPTL3
Homology/Alignments : Family Browser (UCSC)ANGPTL3
Phylogenetic Trees/Animal Genes : TreeFamANGPTL3
Chemical/Protein Interactions : CTD27329
Chemical/Pharm GKB GenePA24796
Clinical trialANGPTL3
Cancer Resource (Charite)ENSG00000132855
Other databases
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
CoreMineANGPTL3
GoPubMedANGPTL3
iHOPANGPTL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 18:46:52 CEST 2015

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