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ANK3 (ankyrin 3)

Identity

Alias_namesankyrin 3
Other aliasANKYRIN-G
MRT37
HGNC (Hugo) ANK3
LocusID (NCBI) 288
Atlas_Id 45914
Location 10q21.2  [Link to chromosome band 10q21]
Location_base_pair Starts at 60026298 and ends at 60141016 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKT3 (1q43) / ANK3 (10q21.2)ANK3 (10q21.2) / ATAD1 (10q23.31)ANK3 (10q21.2) / CCDC106 (19q13.42)
ANK3 (10q21.2) / CDK1 (10q21.2)ANK3 (10q21.2) / CHN2 (7p14.3)ANK3 (10q21.2) / IFIT5 (10q23.31)
ANK3 (10q21.2) / RHOBTB1 (10q21.2)ANK3 (10q21.2) / RPS3 (11q13.4)ANK3 (10q21.2) / SP2 (17q21.32)
ANK3 (10q21.2) / TMPRSS15 (21q21.1)ANK3 (10q21.2) / USP9Y (Yq11.21)ANK3 (10q21.2) / WDFY4 (10q11.22)
CCDC6 (10q21.2) / ANK3 (10q21.2)CCNY (10p11.21) / ANK3 (10q21.2)JMJD1C (10q21.3) / ANK3 (10q21.2)
KIAA0930 (22q13.31) / ANK3 (10q21.2)PHEX (Xp22.11) / ANK3 (10q21.2)RET (10q11.21) / ANK3 (10q21.2)
SLC16A9 (10q21.2) / ANK3 (10q21.2)TRAPPC8 (18q12.1) / ANK3 (10q21.2)TTLL13P (15q26.1) / ANK3 (10q21.2)
ANK3 10q21.2 / ATAD1 10q23.31ANK3 10q21.2 / CDK1 10q21.2ANK3 10q21.2 / CHN2 7p14.3
ANK3 10q21.2 / IFIT5 10q23.31ANK3 10q21.2 / RHOBTB1 10q21.2ANK3 10q21.2 / SP2 17q21.32
ANK3 10q21.2 / TMPRSS15 21q21.1ANK3 10q21.2 / USP9Y Yq11.21ANK3 10q21.2 / WDFY4 10q11.22
CCDC6 10q21.2 / ANK3 10q21.2CCNY 10p11.21 / ANK3 10q21.2JMJD1C 10q21.3 / ANK3 10q21.2
KIAA0930 22q13.31 / ANK3 10q21.2RET 10q11.21 / ANK3 10q21.2SLC16A9 10q21.2 / ANK3 10q21.2
TRAPPC8 18q12.1 / ANK3 10q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ANK3   494
Cards
Entrez_Gene (NCBI)ANK3  288  ankyrin 3
AliasesANKYRIN-G; MRT37
GeneCards (Weizmann)ANK3
Ensembl hg19 (Hinxton)ENSG00000151150 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151150 [Gene_View]  chr10:60026298-60141016 [Contig_View]  ANK3 [Vega]
ICGC DataPortalENSG00000151150
TCGA cBioPortalANK3
AceView (NCBI)ANK3
Genatlas (Paris)ANK3
WikiGenes288
SOURCE (Princeton)ANK3
Genetics Home Reference (NIH)ANK3
Genomic and cartography
GoldenPath hg38 (UCSC)ANK3  -     chr10:60026298-60141016 -  10q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANK3  -     10q21.2   [Description]    (hg19-Feb_2009)
EnsemblANK3 - 10q21.2 [CytoView hg19]  ANK3 - 10q21.2 [CytoView hg38]
Mapping of homologs : NCBIANK3 [Mapview hg19]  ANK3 [Mapview hg38]
OMIM600465   615493   
Gene and transcription
Genbank (Entrez)AB209308 AK092361 AK092527 AK124230 AK126851
RefSeq transcript (Entrez)NM_001149 NM_001204403 NM_001204404 NM_001320874 NM_020987
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANK3
Cluster EST : UnigeneHs.740100 [ NCBI ]
CGAP (NCI)Hs.740100
Alternative Splicing GalleryENSG00000151150
Gene ExpressionANK3 [ NCBI-GEO ]   ANK3 [ EBI - ARRAY_EXPRESS ]   ANK3 [ SEEK ]   ANK3 [ MEM ]
Gene Expression Viewer (FireBrowse)ANK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)288
GTEX Portal (Tissue expression)ANK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12955   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12955  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12955
Splice isoforms : SwissVarQ12955
PhosPhoSitePlusQ12955
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    DEATH_DOMAIN (PS50017)    ZU5 (PS51145)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    DEATH-like_dom    Death_domain    ZU5_dom   
Domain families : Pfam (Sanger)Ank (PF00023)    Ank_2 (PF12796)    Ank_3 (PF13606)    Death (PF00531)    ZU5 (PF00791)   
Domain families : Pfam (NCBI)pfam00023    pfam12796    pfam13606    pfam00531    pfam00791   
Domain families : Smart (EMBL)ANK (SM00248)  DEATH (SM00005)  ZU5 (SM00218)  
Conserved Domain (NCBI)ANK3
DMDM Disease mutations288
Blocks (Seattle)ANK3
PDB (SRS)4O6X   
PDB (PDBSum)4O6X   
PDB (IMB)4O6X   
PDB (RSDB)4O6X   
Structural Biology KnowledgeBase4O6X   
SCOP (Structural Classification of Proteins)4O6X   
CATH (Classification of proteins structures)4O6X   
SuperfamilyQ12955
Human Protein AtlasENSG00000151150
Peptide AtlasQ12955
HPRD02715
IPIIPI00921566   IPI00552864   IPI00333558   IPI00871968   IPI00909984   IPI01009763   IPI01015955   IPI00472779   IPI00871666   IPI00967510   IPI00967812   IPI00967150   IPI00967242   IPI01010264   IPI00966889   IPI00964604   IPI00964884   IPI00964469   IPI00967298   IPI00966118   
Protein Interaction databases
DIP (DOE-UCLA)Q12955
IntAct (EBI)Q12955
FunCoupENSG00000151150
BioGRIDANK3
STRING (EMBL)ANK3
ZODIACANK3
Ontologies - Pathways
QuickGOQ12955
Ontology : AmiGOmitotic cytokinesis  structural constituent of cytoskeleton  protein binding  lysosome  endoplasmic reticulum  Golgi apparatus  cytosol  plasma membrane  plasma membrane  bicellular tight junction  ER to Golgi vesicle-mediated transport  plasma membrane organization  cytoskeletal anchoring at plasma membrane  signal transduction  axonogenesis  neuromuscular junction development  cytoskeletal protein binding  basal plasma membrane  cell surface  positive regulation of gene expression  positive regulation of cell communication by electrical coupling  positive regulation of sodium ion transport  magnesium ion homeostasis  intercalated disc  spectrin-associated cytoskeleton  basolateral plasma membrane  lateral plasma membrane  sarcoplasmic reticulum  neuronal action potential  Z disc  T-tubule  dendrite  spectrin binding  spectrin binding  protein binding, bridging  neuromuscular junction  node of Ranvier  positive regulation of homotypic cell-cell adhesion  sarcolemma  Golgi to plasma membrane protein transport  neuron projection  costamere  axon initial segment  axon initial segment  regulation of potassium ion transport  ion channel binding  establishment of protein localization  postsynaptic membrane  cadherin binding  positive regulation of membrane potential  cellular response to magnesium ion  membrane assembly  membrane assembly  protein localization to plasma membrane  protein localization to plasma membrane  protein localization to plasma membrane  maintenance of protein location in plasma membrane  protein targeting to plasma membrane  positive regulation of protein targeting to membrane  positive regulation of membrane depolarization during cardiac muscle cell action potential  negative regulation of delayed rectifier potassium channel activity  positive regulation of sodium ion transmembrane transporter activity  positive regulation of cation channel activity  
Ontology : EGO-EBImitotic cytokinesis  structural constituent of cytoskeleton  protein binding  lysosome  endoplasmic reticulum  Golgi apparatus  cytosol  plasma membrane  plasma membrane  bicellular tight junction  ER to Golgi vesicle-mediated transport  plasma membrane organization  cytoskeletal anchoring at plasma membrane  signal transduction  axonogenesis  neuromuscular junction development  cytoskeletal protein binding  basal plasma membrane  cell surface  positive regulation of gene expression  positive regulation of cell communication by electrical coupling  positive regulation of sodium ion transport  magnesium ion homeostasis  intercalated disc  spectrin-associated cytoskeleton  basolateral plasma membrane  lateral plasma membrane  sarcoplasmic reticulum  neuronal action potential  Z disc  T-tubule  dendrite  spectrin binding  spectrin binding  protein binding, bridging  neuromuscular junction  node of Ranvier  positive regulation of homotypic cell-cell adhesion  sarcolemma  Golgi to plasma membrane protein transport  neuron projection  costamere  axon initial segment  axon initial segment  regulation of potassium ion transport  ion channel binding  establishment of protein localization  postsynaptic membrane  cadherin binding  positive regulation of membrane potential  cellular response to magnesium ion  membrane assembly  membrane assembly  protein localization to plasma membrane  protein localization to plasma membrane  protein localization to plasma membrane  maintenance of protein location in plasma membrane  protein targeting to plasma membrane  positive regulation of protein targeting to membrane  positive regulation of membrane depolarization during cardiac muscle cell action potential  negative regulation of delayed rectifier potassium channel activity  positive regulation of sodium ion transmembrane transporter activity  positive regulation of cation channel activity  
Pathways : KEGGProteoglycans in cancer   
NDEx NetworkANK3
Atlas of Cancer Signalling NetworkANK3
Wikipedia pathwaysANK3
Orthology - Evolution
OrthoDB288
GeneTree (enSembl)ENSG00000151150
Phylogenetic Trees/Animal Genes : TreeFamANK3
HOVERGENQ12955
HOGENOMQ12955
Homologs : HomoloGeneANK3
Homology/Alignments : Family Browser (UCSC)ANK3
Gene fusions - Rearrangements
Fusion : MitelmanANK3/ATAD1 [10q21.2/10q23.31]  
Fusion : MitelmanANK3/CDK1 [10q21.2/10q21.2]  [t(10;10)(q21;q21)]  
Fusion : MitelmanANK3/CHN2 [10q21.2/7p14.3]  [t(7;10)(p14;q21)]  
Fusion : MitelmanANK3/IFIT5 [10q21.2/10q23.31]  [t(10;10)(q21;q23)]  
Fusion : MitelmanANK3/RHOBTB1 [10q21.2/10q21.2]  [t(10;10)(q21;q21)]  
Fusion : MitelmanANK3/SP2 [10q21.2/17q21.32]  [t(10;17)(q21;q21)]  
Fusion : MitelmanANK3/TMPRSS15 [10q21.2/21q21.1]  [t(10;21)(q21;q21)]  
Fusion : MitelmanANK3/USP9Y [10q21.2/Yq11.21]  [t(Y;10)(q11;q21)]  
Fusion : MitelmanANK3/WDFY4 [10q21.2/10q11.22]  [t(10;10)(q11;q21)]  
Fusion : MitelmanCCDC6/ANK3 [10q21.2/10q21.2]  [t(10;10)(q21;q21)]  
Fusion : MitelmanCCNY/ANK3 [10p11.21/10q21.2]  [t(10;10)(p11;q21)]  
Fusion : MitelmanJMJD1C/ANK3 [10q21.3/10q21.2]  [t(10;10)(q21;q21)]  
Fusion : MitelmanKIAA0930/ANK3 [22q13.31/10q21.2]  [t(10;22)(q21;q13)]  
Fusion : MitelmanRET/ANK3 [10q11.21/10q21.2]  [t(10;10)(q11;q21)]  
Fusion : MitelmanSLC16A9/ANK3 [10q21.2/10q21.2]  [t(10;10)(q21;q21)]  
Fusion : MitelmanTRAPPC8/ANK3 [18q12.1/10q21.2]  [t(10;18)(q21;q12)]  
Fusion: TCGAANK3 10q21.2 ATAD1 10q23.31 BRCA
Fusion: TCGAANK3 10q21.2 CDK1 10q21.2 BRCA
Fusion: TCGAANK3 10q21.2 CHN2 7p14.3 BRCA
Fusion: TCGAANK3 10q21.2 IFIT5 10q23.31 BRCA
Fusion: TCGAANK3 10q21.2 RHOBTB1 10q21.2 BRCA
Fusion: TCGAANK3 10q21.2 SP2 17q21.32 BRCA
Fusion: TCGAANK3 10q21.2 TMPRSS15 21q21.1 BRCA
Fusion: TCGAANK3 10q21.2 USP9Y Yq11.21 PRAD
Fusion: TCGAANK3 10q21.2 WDFY4 10q11.22 BRCA
Fusion: TCGACCDC6 10q21.2 ANK3 10q21.2 BRCA LUAD OV
Fusion: TCGACCNY 10p11.21 ANK3 10q21.2 BLCA
Fusion: TCGAJMJD1C 10q21.3 ANK3 10q21.2 PRAD
Fusion: TCGAKIAA0930 22q13.31 ANK3 10q21.2 BRCA
Fusion: TCGARET 10q11.21 ANK3 10q21.2 THCA
Fusion: TCGASLC16A9 10q21.2 ANK3 10q21.2 HNSC
Fusion: TCGATRAPPC8 18q12.1 ANK3 10q21.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANK3
dbVarANK3
ClinVarANK3
1000_GenomesANK3 
Exome Variant ServerANK3
ExAC (Exome Aggregation Consortium)ANK3 (select the gene name)
Genetic variants : HAPMAP288
Genomic Variants (DGV)ANK3 [DGVbeta]
DECIPHERANK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANK3 
Mutations
ICGC Data PortalANK3 
TCGA Data PortalANK3 
Broad Tumor PortalANK3
OASIS PortalANK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANK3
intOGen PortalANK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANK3
DgiDB (Drug Gene Interaction Database)ANK3
DoCM (Curated mutations)ANK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANK3 (select a term)
intoGenANK3
Cancer3DANK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600465    615493   
Orphanet22193   
MedgenANK3
Genetic Testing Registry ANK3
NextProtQ12955 [Medical]
TSGene288
GENETestsANK3
Huge Navigator ANK3 [HugePedia]
snp3D : Map Gene to Disease288
BioCentury BCIQANK3
ClinGenANK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD288
Chemical/Pharm GKB GenePA24800
Clinical trialANK3
Miscellaneous
canSAR (ICR)ANK3 (select the gene name)
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANK3
EVEXANK3
GoPubMedANK3
iHOPANK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:05:57 CEST 2017

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