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ANKRD11 (ankyrin repeat domain 11)

Identity

Alias_symbol (synonym)LZ16
T13
Other aliasANCO-1
ANCO1
HGNC (Hugo) ANKRD11
LocusID (NCBI) 29123
Atlas_Id 644
Location 16q24.3  [Link to chromosome band 16q24]
Location_base_pair Starts at 89267621 and ends at 89490561 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAM10 (15q21.3) / ANKRD11 (16q24.3)ANKRD11 (16q24.3) / ANKRD11 (16q24.3)ANKRD11 (16q24.3) / DPEP1 (16q24.3)
ANKRD11 (16q24.3) / FANCA (16q24.3)ANKRD11 (16q24.3) / FAU (11q13.1)ANKRD11 (16q24.3) / GOLGB1 (3q13.33)
ANKRD11 (16q24.3) / HABP4 (9q22.32)ANKRD11 (16q24.3) / HUWE1 (Xp11.22)ANKRD11 (16q24.3) / KLHL32 (6q16.1)
ANKRD11 (16q24.3) / LINGO1 (15q24.3)ANKRD11 (16q24.3) / RNF11 (1p32.3)ANKRD11 (16q24.3) / RNF135 (17q11.2)
ANKRD11 (16q24.3) / S100A9 (1q21.3)ANKRD11 (16q24.3) / TGIF1 (18p11.31)CDS2 (20p12.3) / ANKRD11 (16q24.3)
COPG1 (3q21.3) / ANKRD11 (16q24.3)DNAJA2 (16q11.2) / ANKRD11 (16q24.3)FURIN (15q26.1) / ANKRD11 (16q24.3)
IL12RB2 (1p31.3) / ANKRD11 (16q24.3)LDLR (19p13.2) / ANKRD11 (16q24.3)PTK2 (8q24.3) / ANKRD11 (16q24.3)
TYSND1 (10q22.1) / ANKRD11 (16q24.3)ANKRD11 16q24.3 / DPEP1 16q24.3ANKRD11 16q24.3 / FANCA 16q24.3
ANKRD11 16q24.3 / KLHL32 6q16.1ANKRD11 16q24.3 / LINGO1 15q24.3ANKRD11 16q24.3 / TGIF1 18p11.31
PTK2 8q24.3 / ANKRD11 16q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(16;16)(q24;q24) ANKRD11/SPG7
t(16;20)(q24;p12) CDS2/ANKRD11

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(6;16)(q16;q24) ANKRD11/KLHL32
t(8;16)(q24;q24) PTK2/ANKRD11
t(15;16)(q24;q24) ANKRD11/LINGO1
ANKRD11/DPEP1 (16q24)
ANKRD11/FANCA (16q24)
t(16;18)(q24;p11) ANKRD11/TGIF1

External links

Nomenclature
HGNC (Hugo)ANKRD11   21316
Cards
Entrez_Gene (NCBI)ANKRD11  29123  ankyrin repeat domain 11
AliasesANCO-1; ANCO1; LZ16; T13
GeneCards (Weizmann)ANKRD11
Ensembl hg19 (Hinxton)ENSG00000167522 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167522 [Gene_View]  ENSG00000167522 [Sequence]  chr16:89267621-89490561 [Contig_View]  ANKRD11 [Vega]
ICGC DataPortalENSG00000167522
TCGA cBioPortalANKRD11
AceView (NCBI)ANKRD11
Genatlas (Paris)ANKRD11
WikiGenes29123
SOURCE (Princeton)ANKRD11
Genetics Home Reference (NIH)ANKRD11
Genomic and cartography
GoldenPath hg38 (UCSC)ANKRD11  -     chr16:89267621-89490561 -  16q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANKRD11  -     16q24.3   [Description]    (hg19-Feb_2009)
EnsemblANKRD11 - 16q24.3 [CytoView hg19]  ANKRD11 - 16q24.3 [CytoView hg38]
Mapping of homologs : NCBIANKRD11 [Mapview hg19]  ANKRD11 [Mapview hg38]
OMIM148050   611192   
Gene and transcription
Genbank (Entrez)AB209186 AF121775 AF130076 AK025964 AK057803
RefSeq transcript (Entrez)NM_001256182 NM_001256183 NM_013275
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANKRD11
Cluster EST : UnigeneHs.740440 [ NCBI ]
CGAP (NCI)Hs.740440
Alternative Splicing GalleryENSG00000167522
Gene ExpressionANKRD11 [ NCBI-GEO ]   ANKRD11 [ EBI - ARRAY_EXPRESS ]   ANKRD11 [ SEEK ]   ANKRD11 [ MEM ]
Gene Expression Viewer (FireBrowse)ANKRD11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29123
GTEX Portal (Tissue expression)ANKRD11
Human Protein AtlasENSG00000167522-ANKRD11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UB99   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UB99  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UB99
Splice isoforms : SwissVarQ6UB99
PhosPhoSitePlusQ6UB99
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf   
Domain families : Pfam (Sanger)Ank (PF00023)    Ank_2 (PF12796)   
Domain families : Pfam (NCBI)pfam00023    pfam12796   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)ANKRD11
DMDM Disease mutations29123
Blocks (Seattle)ANKRD11
SuperfamilyQ6UB99
Human Protein Atlas [tissue]ENSG00000167522-ANKRD11 [tissue]
Peptide AtlasQ6UB99
HPRD12456
IPIIPI00555890   IPI00217193   IPI00412963   IPI00914930   
Protein Interaction databases
DIP (DOE-UCLA)Q6UB99
IntAct (EBI)Q6UB99
FunCoupENSG00000167522
BioGRIDANKRD11
STRING (EMBL)ANKRD11
ZODIACANKRD11
Ontologies - Pathways
QuickGOQ6UB99
Ontology : AmiGOin utero embryonic development  tissue homeostasis  nucleus  nucleus  nucleoplasm  cytosol  plasma membrane  anatomical structure morphogenesis  multicellular organism growth  odontogenesis of dentin-containing tooth  skeletal system morphogenesis  face morphogenesis  bone development  
Ontology : EGO-EBIin utero embryonic development  tissue homeostasis  nucleus  nucleus  nucleoplasm  cytosol  plasma membrane  anatomical structure morphogenesis  multicellular organism growth  odontogenesis of dentin-containing tooth  skeletal system morphogenesis  face morphogenesis  bone development  
NDEx NetworkANKRD11
Atlas of Cancer Signalling NetworkANKRD11
Wikipedia pathwaysANKRD11
Orthology - Evolution
OrthoDB29123
GeneTree (enSembl)ENSG00000167522
Phylogenetic Trees/Animal Genes : TreeFamANKRD11
HOVERGENQ6UB99
HOGENOMQ6UB99
Homologs : HomoloGeneANKRD11
Homology/Alignments : Family Browser (UCSC)ANKRD11
Gene fusions - Rearrangements
Fusion : MitelmanANKRD11/DPEP1 [16q24.3/16q24.3]  
Fusion : MitelmanANKRD11/FANCA [16q24.3/16q24.3]  [t(16;16)(q24;q24)]  
Fusion : MitelmanANKRD11/KLHL32 [16q24.3/6q16.1]  [t(6;16)(q16;q24)]  
Fusion : MitelmanANKRD11/LINGO1 [16q24.3/15q24.3]  [t(15;16)(q24;q24)]  
Fusion : MitelmanANKRD11/TGIF1 [16q24.3/18p11.31]  [t(16;18)(q24;p11)]  
Fusion : MitelmanPTK2/ANKRD11 [8q24.3/16q24.3]  [t(8;16)(q24;q24)]  
Fusion PortalANKRD11 16q24.3 DPEP1 16q24.3 THCA
Fusion PortalANKRD11 16q24.3 FANCA 16q24.3 LUAD
Fusion PortalANKRD11 16q24.3 KLHL32 6q16.1 OV
Fusion PortalANKRD11 16q24.3 LINGO1 15q24.3 BRCA
Fusion PortalANKRD11 16q24.3 TGIF1 18p11.31 LUAD
Fusion PortalPTK2 8q24.3 ANKRD11 16q24.3 LUAD
Fusion : QuiverANKRD11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANKRD11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANKRD11
dbVarANKRD11
ClinVarANKRD11
1000_GenomesANKRD11 
Exome Variant ServerANKRD11
ExAC (Exome Aggregation Consortium)ENSG00000167522
GNOMAD BrowserENSG00000167522
Varsome BrowserANKRD11
Genetic variants : HAPMAP29123
Genomic Variants (DGV)ANKRD11 [DGVbeta]
DECIPHERANKRD11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANKRD11 
Mutations
ICGC Data PortalANKRD11 
TCGA Data PortalANKRD11 
Broad Tumor PortalANKRD11
OASIS PortalANKRD11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANKRD11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANKRD11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANKRD11
DgiDB (Drug Gene Interaction Database)ANKRD11
DoCM (Curated mutations)ANKRD11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANKRD11 (select a term)
intoGenANKRD11
Cancer3DANKRD11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM148050    611192   
Orphanet2184    19864   
DisGeNETANKRD11
MedgenANKRD11
Genetic Testing Registry ANKRD11
NextProtQ6UB99 [Medical]
TSGene29123
GENETestsANKRD11
Target ValidationANKRD11
Huge Navigator ANKRD11 [HugePedia]
snp3D : Map Gene to Disease29123
BioCentury BCIQANKRD11
ClinGenANKRD11 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29123
Chemical/Pharm GKB GenePA134861925
Clinical trialANKRD11
Miscellaneous
canSAR (ICR)ANKRD11 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANKRD11
EVEXANKRD11
GoPubMedANKRD11
iHOPANKRD11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:09:03 CEST 2018
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