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ANKRD27 (ankyrin repeat domain 27)

Identity

Alias_namesankyrin repeat domain 27 (VPS9 domain)
Alias_symbol (synonym)FLJ00040
DKFZp434L0718
VARP
Other aliasPP12899
HGNC (Hugo) ANKRD27
LocusID (NCBI) 84079
Atlas_Id 54125
Location 19q13.11  [Link to chromosome band 19q13]
Location_base_pair Starts at 32597001 and ends at 32675196 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKRD27 (19q13.11) / ANKRD27 (19q13.11)ANKRD27 (19q13.11) / DHRS11 (17q12)ANKRD27 (19q13.11) / SLC7A9 (19q13.11)
ANKRD27 (19q13.11) / ZFP14 (19q13.12)PSMB6 (17p13.2) / ANKRD27 (19q13.11)RHPN2 (19q13.11) / ANKRD27 (19q13.11)
SENP2 (3q27.2) / ANKRD27 (19q13.11)ANKRD27 19q13.11 / ZFP14 19q13.12SENP2 3q27.2 / ANKRD27 19q13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)ANKRD27   25310
Cards
Entrez_Gene (NCBI)ANKRD27  84079  ankyrin repeat domain 27
AliasesPP12899; VARP
GeneCards (Weizmann)ANKRD27
Ensembl hg19 (Hinxton)ENSG00000105186 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105186 [Gene_View]  chr19:32597001-32675196 [Contig_View]  ANKRD27 [Vega]
ICGC DataPortalENSG00000105186
TCGA cBioPortalANKRD27
AceView (NCBI)ANKRD27
Genatlas (Paris)ANKRD27
WikiGenes84079
SOURCE (Princeton)ANKRD27
Genetics Home Reference (NIH)ANKRD27
Genomic and cartography
GoldenPath hg38 (UCSC)ANKRD27  -     chr19:32597001-32675196 -  19q13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANKRD27  -     19q13.11   [Description]    (hg19-Feb_2009)
EnsemblANKRD27 - 19q13.11 [CytoView hg19]  ANKRD27 - 19q13.11 [CytoView hg38]
Mapping of homologs : NCBIANKRD27 [Mapview hg19]  ANKRD27 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA903176 AF447882 AK054561 AL136784 AL834335
RefSeq transcript (Entrez)NM_032139
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANKRD27
Cluster EST : UnigeneHs.59236 [ NCBI ]
CGAP (NCI)Hs.59236
Alternative Splicing GalleryENSG00000105186
Gene ExpressionANKRD27 [ NCBI-GEO ]   ANKRD27 [ EBI - ARRAY_EXPRESS ]   ANKRD27 [ SEEK ]   ANKRD27 [ MEM ]
Gene Expression Viewer (FireBrowse)ANKRD27 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84079
GTEX Portal (Tissue expression)ANKRD27
Human Protein AtlasENSG00000105186-ANKRD27 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NW4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NW4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NW4
Splice isoforms : SwissVarQ96NW4
PhosPhoSitePlusQ96NW4
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    VPS9 (PS51205)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    VPS9   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    Ank_3 (PF13606)    VPS9 (PF02204)   
Domain families : Pfam (NCBI)pfam12796    pfam13606    pfam02204   
Domain families : Smart (EMBL)ANK (SM00248)  VPS9 (SM00167)  
Conserved Domain (NCBI)ANKRD27
DMDM Disease mutations84079
Blocks (Seattle)ANKRD27
PDB (SRS)4B93    4CYM    4CZ2   
PDB (PDBSum)4B93    4CYM    4CZ2   
PDB (IMB)4B93    4CYM    4CZ2   
PDB (RSDB)4B93    4CYM    4CZ2   
Structural Biology KnowledgeBase4B93    4CYM    4CZ2   
SCOP (Structural Classification of Proteins)4B93    4CYM    4CZ2   
CATH (Classification of proteins structures)4B93    4CYM    4CZ2   
SuperfamilyQ96NW4
Human Protein Atlas [tissue]ENSG00000105186-ANKRD27 [tissue]
Peptide AtlasQ96NW4
HPRD10650
IPIIPI00102377   
Protein Interaction databases
DIP (DOE-UCLA)Q96NW4
IntAct (EBI)Q96NW4
FunCoupENSG00000105186
BioGRIDANKRD27
STRING (EMBL)ANKRD27
ZODIACANKRD27
Ontologies - Pathways
QuickGOQ96NW4
Ontology : AmiGOSNARE binding  guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  lysosome  early endosome  late endosome  cytosol  plasma membrane  protein transport  membrane  Rab guanyl-nucleotide exchange factor activity  Rab GTPase binding  transport vesicle  cytoplasmic vesicle membrane  negative regulation of SNARE complex assembly  endosome to melanosome transport  melanosome  neuron projection  positive regulation of GTPase activity  early endosome to late endosome transport  neuron projection morphogenesis  positive regulation of dendrite morphogenesis  membrane organization  tubular endosome  retrograde transport, endosome to plasma membrane  
Ontology : EGO-EBISNARE binding  guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  lysosome  early endosome  late endosome  cytosol  plasma membrane  protein transport  membrane  Rab guanyl-nucleotide exchange factor activity  Rab GTPase binding  transport vesicle  cytoplasmic vesicle membrane  negative regulation of SNARE complex assembly  endosome to melanosome transport  melanosome  neuron projection  positive regulation of GTPase activity  early endosome to late endosome transport  neuron projection morphogenesis  positive regulation of dendrite morphogenesis  membrane organization  tubular endosome  retrograde transport, endosome to plasma membrane  
NDEx NetworkANKRD27
Atlas of Cancer Signalling NetworkANKRD27
Wikipedia pathwaysANKRD27
Orthology - Evolution
OrthoDB84079
GeneTree (enSembl)ENSG00000105186
Phylogenetic Trees/Animal Genes : TreeFamANKRD27
HOVERGENQ96NW4
HOGENOMQ96NW4
Homologs : HomoloGeneANKRD27
Homology/Alignments : Family Browser (UCSC)ANKRD27
Gene fusions - Rearrangements
Fusion : MitelmanANKRD27/ZFP14 [19q13.11/19q13.12]  
Fusion : MitelmanRHPN2/ANKRD27 [19q13.11/19q13.11]  [t(19;19)(q13;q13)]  
Fusion : MitelmanSENP2/ANKRD27 [3q27.2/19q13.11]  [t(3;19)(q27;q13)]  
Fusion: TCGA_MDACCANKRD27 19q13.11 ZFP14 19q13.12 LUSC
Fusion: TCGA_MDACCSENP2 3q27.2 ANKRD27 19q13.11 LUSC
Tumor Fusion PortalANKRD27
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANKRD27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANKRD27
dbVarANKRD27
ClinVarANKRD27
1000_GenomesANKRD27 
Exome Variant ServerANKRD27
ExAC (Exome Aggregation Consortium)ENSG00000105186
GNOMAD BrowserENSG00000105186
Genetic variants : HAPMAP84079
Genomic Variants (DGV)ANKRD27 [DGVbeta]
DECIPHERANKRD27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANKRD27 
Mutations
ICGC Data PortalANKRD27 
TCGA Data PortalANKRD27 
Broad Tumor PortalANKRD27
OASIS PortalANKRD27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANKRD27  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANKRD27
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANKRD27
DgiDB (Drug Gene Interaction Database)ANKRD27
DoCM (Curated mutations)ANKRD27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANKRD27 (select a term)
intoGenANKRD27
Cancer3DANKRD27(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETANKRD27
MedgenANKRD27
Genetic Testing Registry ANKRD27
NextProtQ96NW4 [Medical]
TSGene84079
GENETestsANKRD27
Target ValidationANKRD27
Huge Navigator ANKRD27 [HugePedia]
snp3D : Map Gene to Disease84079
BioCentury BCIQANKRD27
ClinGenANKRD27
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84079
Chemical/Pharm GKB GenePA134893411
Clinical trialANKRD27
Miscellaneous
canSAR (ICR)ANKRD27 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANKRD27
EVEXANKRD27
GoPubMedANKRD27
iHOPANKRD27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:03:03 CET 2017

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