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ANKRD27 (ankyrin repeat domain 27)

Identity

Alias (NCBI)PP12899
VARP
HGNC (Hugo) ANKRD27
HGNC Alias symbFLJ00040
DKFZp434L0718
VARP
HGNC Alias nameVps9 domain and ankyrin-repeat-containing protein
HGNC Previous nameankyrin repeat domain 27 (VPS9 domain)
LocusID (NCBI) 84079
Atlas_Id 54125
Location 19q13.11  [Link to chromosome band 19q13]
Location_base_pair Starts at 32597006 and ends at 32675180 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKRD27 (19q13.11) / ANKRD27 (19q13.11)ANKRD27 (19q13.11) / DHRS11 (17q12)ANKRD27 (19q13.11) / SLC7A9 (19q13.11)
ANKRD27 (19q13.11) / ZFP14 (19q13.12)PSMB6 (17p13.2) / ANKRD27 (19q13.11)RHPN2 (19q13.11) / ANKRD27 (19q13.11)
SENP2 (3q27.2) / ANKRD27 (19q13.11)ANKRD27 19q13.11 / ZFP14 19q13.12SENP2 3q27.2 / ANKRD27 19q13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ANKRD27   25310
Cards
Entrez_Gene (NCBI)ANKRD27    ankyrin repeat domain 27
AliasesPP12899; VARP
GeneCards (Weizmann)ANKRD27
Ensembl hg19 (Hinxton)ENSG00000105186 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105186 [Gene_View]  ENSG00000105186 [Sequence]  chr19:32597006-32675180 [Contig_View]  ANKRD27 [Vega]
ICGC DataPortalENSG00000105186
TCGA cBioPortalANKRD27
AceView (NCBI)ANKRD27
Genatlas (Paris)ANKRD27
SOURCE (Princeton)ANKRD27
Genetics Home Reference (NIH)ANKRD27
Genomic and cartography
GoldenPath hg38 (UCSC)ANKRD27  -     chr19:32597006-32675180 -  19q13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANKRD27  -     19q13.11   [Description]    (hg19-Feb_2009)
GoldenPathANKRD27 - 19q13.11 [CytoView hg19]  ANKRD27 - 19q13.11 [CytoView hg38]
ImmunoBaseENSG00000105186
Genome Data Viewer NCBIANKRD27 [Mapview hg19]  
OMIM618957   
Gene and transcription
Genbank (Entrez)AA903176 AF447882 AK054561 AL136784 AL834335
RefSeq transcript (Entrez)NM_032139
Consensus coding sequences : CCDS (NCBI)ANKRD27
Gene ExpressionANKRD27 [ NCBI-GEO ]   ANKRD27 [ EBI - ARRAY_EXPRESS ]   ANKRD27 [ SEEK ]   ANKRD27 [ MEM ]
Gene Expression Viewer (FireBrowse)ANKRD27 [ Firebrowse - Broad ]
GenevisibleExpression of ANKRD27 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84079
GTEX Portal (Tissue expression)ANKRD27
Human Protein AtlasENSG00000105186-ANKRD27 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NW4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NW4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NW4
PhosPhoSitePlusQ96NW4
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    VPS9 (PS51205)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    VPS9    VPS9_dom_sf   
Domain families : Pfam (Sanger)Ank (PF00023)    Ank_2 (PF12796)    VPS9 (PF02204)   
Domain families : Pfam (NCBI)pfam00023    pfam12796    pfam02204   
Domain families : Smart (EMBL)ANK (SM00248)  VPS9 (SM00167)  
Conserved Domain (NCBI)ANKRD27
PDB (RSDB)4B93    4CYM    4CZ2    6TL0   
PDB Europe4B93    4CYM    4CZ2    6TL0   
PDB (PDBSum)4B93    4CYM    4CZ2    6TL0   
PDB (IMB)4B93    4CYM    4CZ2    6TL0   
Structural Biology KnowledgeBase4B93    4CYM    4CZ2    6TL0   
SCOP (Structural Classification of Proteins)4B93    4CYM    4CZ2    6TL0   
CATH (Classification of proteins structures)4B93    4CYM    4CZ2    6TL0   
SuperfamilyQ96NW4
AlphaFold pdb e-kbQ96NW4   
Human Protein Atlas [tissue]ENSG00000105186-ANKRD27 [tissue]
HPRD10650
Protein Interaction databases
DIP (DOE-UCLA)Q96NW4
IntAct (EBI)Q96NW4
BioGRIDANKRD27
STRING (EMBL)ANKRD27
ZODIACANKRD27
Ontologies - Pathways
QuickGOQ96NW4
Ontology : AmiGOSNARE binding  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  lysosome  early endosome  early endosome  late endosome  late endosome  cytosol  plasma membrane  plasma membrane  positive regulation of neuron projection development  protein transport  membrane  transport vesicle  cytoplasmic vesicle membrane  small GTPase binding  endocytic recycling  endocytic recycling  negative regulation of SNARE complex assembly  endosome to melanosome transport  melanosome  neuron projection  early endosome to late endosome transport  early endosome to late endosome transport  neuron projection morphogenesis  positive regulation of dendrite morphogenesis  regulation of catalytic activity  tubular endosome  tubular endosome  
Ontology : EGO-EBISNARE binding  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  protein binding  lysosome  early endosome  early endosome  late endosome  late endosome  cytosol  plasma membrane  plasma membrane  positive regulation of neuron projection development  protein transport  membrane  transport vesicle  cytoplasmic vesicle membrane  small GTPase binding  endocytic recycling  endocytic recycling  negative regulation of SNARE complex assembly  endosome to melanosome transport  melanosome  neuron projection  early endosome to late endosome transport  early endosome to late endosome transport  neuron projection morphogenesis  positive regulation of dendrite morphogenesis  regulation of catalytic activity  tubular endosome  tubular endosome  
NDEx NetworkANKRD27
Atlas of Cancer Signalling NetworkANKRD27
Wikipedia pathwaysANKRD27
Orthology - Evolution
OrthoDB84079
GeneTree (enSembl)ENSG00000105186
Phylogenetic Trees/Animal Genes : TreeFamANKRD27
Homologs : HomoloGeneANKRD27
Homology/Alignments : Family Browser (UCSC)ANKRD27
Gene fusions - Rearrangements
Fusion : MitelmanANKRD27/ZFP14 [19q13.11/19q13.12]  
Fusion : MitelmanRHPN2/ANKRD27 [19q13.11/19q13.11]  
Fusion : MitelmanSENP2/ANKRD27 [3q27.2/19q13.11]  
Fusion : QuiverANKRD27
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANKRD27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANKRD27
dbVarANKRD27
ClinVarANKRD27
MonarchANKRD27
1000_GenomesANKRD27 
Exome Variant ServerANKRD27
GNOMAD BrowserENSG00000105186
Varsome BrowserANKRD27
ACMGANKRD27 variants
VarityQ96NW4
Genomic Variants (DGV)ANKRD27 [DGVbeta]
DECIPHERANKRD27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANKRD27 
Mutations
ICGC Data PortalANKRD27 
TCGA Data PortalANKRD27 
Broad Tumor PortalANKRD27
OASIS PortalANKRD27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANKRD27  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DANKRD27
Mutations and Diseases : HGMDANKRD27
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaANKRD27
DgiDB (Drug Gene Interaction Database)ANKRD27
DoCM (Curated mutations)ANKRD27
CIViC (Clinical Interpretations of Variants in Cancer)ANKRD27
Cancer3DANKRD27
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618957   
Orphanet
DisGeNETANKRD27
MedgenANKRD27
Genetic Testing Registry ANKRD27
NextProtQ96NW4 [Medical]
GENETestsANKRD27
Target ValidationANKRD27
Huge Navigator ANKRD27 [HugePedia]
ClinGenANKRD27
Clinical trials, drugs, therapy
MyCancerGenomeANKRD27
Protein Interactions : CTDANKRD27
Pharm GKB GenePA134893411
PharosQ96NW4
Clinical trialANKRD27
Miscellaneous
canSAR (ICR)ANKRD27
HarmonizomeANKRD27
DataMed IndexANKRD27
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXANKRD27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:59:25 CEST 2021

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