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ANLN (anillin, actin binding protein)

Written2009-01Yataro Daigo, Yusuke Nakamura
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

(Note : for Links provided by Atlas : click)


HGNC Previous nameanillin (Drosophila Scraps homolog), actin binding protein
 anillin, actin binding protein (scraps homolog, Drosophila)
LocusID (NCBI) 54443
Atlas_Id 44318
Location 7p14.2  [Link to chromosome band 7p14]
Location_base_pair Starts at 36389862 and ends at 36453791 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping ANLN.png]
Local_order The human ANLN gene maps on 7p15-p14 between the KIAA0895 and the ENSG00000210490 loci.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANLN (7p14.2)::ANLN (7p14.2)ANLN (7p14.2)::EEPD1 (7p14.2)ANLN (7p14.2)::POU6F2 (7p14.1)
ETV6 (12p13.2)::ANLN (7p14.2)


Description The ANLN gene consists of 63,969 bases and at least 23 exons.
Transcription The transcribed mRNA is 4,786 bp.


Description The human ANLN cDNA encodes a protein (1124 amino acids; 124199 Da) that includes an actin-binding domain and a C-terminal domain with pleckstrin homology (PH). It also contains several consensus nuclear localization sequences (NLS) and one consensus SH3-binding motif.
Expression ANLN is mainly expressed in adult placenta, testis, and spinal cord, and in fetal organs (brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus).
Localisation ANLN is mainly found in nucleus, cytoplasm, cytoskeleton, cleavage furrow, and cell cortex.
Function Anillin (ANLN) was initially characterized as a human homologue of anillin, a Drosophila actin-binding protein. ANLN localizes not only to the cytoplasm but also to nuclei in some proportion of cancer cells; it is likely to present at the cortex following breakdown of the nuclear envelope, and in the cleavage furrow during cytokinesis. ANLN plays an important role in cell-cycle progression. In late phases ANLN may assemble the actin and myosin contractile ring that separates daughter cells, through interaction with at least two other furrow proteins, actin and septins (SEPTs). ANLN is supposed to be a substrate of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that controls mitotic progression.

Implicated in

Entity Lung cancer
Prognosis Nuclear ANLN (n-ANLN) was indicated to be an independent prognostic factor for patients with non-small cell lung cancer.
Oncogenesis ANLN interacts with and activates RHOA, and this complex is likely to be essential for the growth-promoting pathway and aggressive features of lung cancers as well as for cell division. Moreover n-ANLN whose nuclear localization and stability are regulated by PI3K/ AKT signaling, appears to regulate the malignant potential of cancer cells.
Entity Prostate cancer
Note Overexpression of ANLN was observed in hormone-refractory prostate cancers (HRPCs)
Entity Head and neck squamous cell carcinoma
Note Overexpression of ANLN was observed in head and neck squamous cell carcinomas (HNSCCs).


The septin-binding protein anillin is overexpressed in diverse human tumors.
Hall PA, Todd CB, Hyland PL, McDade SS, Grabsch H, Dattani M, Hillan KJ, Russell SE.
Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6780-6.
PMID 16203764
Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling.
Shimizu S, Seki N, Sugimoto T, Horiguchi S, Tanzawa H, Hanazawa T, Okamoto Y.
Oncol Rep. 2007 Dec;18(6):1489-97.
PMID 17982635
ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway.
Suzuki C, Daigo Y, Ishikawa N, Kato T, Hayama S, Ito T, Tsuchiya E, Nakamura Y.
Cancer Res. 2005 Dec 15;65(24):11314-25.
PMID 16357138
Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles.
Tamura K, Furihata M, Tsunoda T, Ashida S, Takata R, Obara W, Yoshioka H, Daigo Y, Nasu Y, Kumon H, Konaka H, Namiki M, Tozawa K, Kohri K, Tanji N, Yokoyama M, Shimazui T, Akaza H, Mizutani Y, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H.
Cancer Res. 2007 Jun 1;67(11):5117-25.
PMID 17545589


This paper should be referenced as such :
Daigo, Y ; Nakamura, Y
ANLN (anillin, actin binding protein)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(12):907-908.
Free journal version : [ pdf ]   [ DOI ]

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;12)(p14;p13) ETV6::ANLN

External links


HGNC (Hugo)ANLN   14082
Entrez_Gene (NCBI)ANLN    anillin actin binding protein
AliasesFSGS8; Scraps; scra
GeneCards (Weizmann)ANLN
Ensembl hg19 (Hinxton)ENSG00000011426 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011426 [Gene_View]  ENSG00000011426 [Sequence]  chr7:36389862-36453791 [Contig_View]  ANLN [Vega]
ICGC DataPortalENSG00000011426
Genatlas (Paris)ANLN
SOURCE (Princeton)ANLN
Genetics Home Reference (NIH)ANLN
Genomic and cartography
GoldenPath hg38 (UCSC)ANLN  -     chr7:36389862-36453791 +  7p14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANLN  -     7p14.2   [Description]    (hg19-Feb_2009)
GoldenPathANLN - 7p14.2 [CytoView hg19]  ANLN - 7p14.2 [CytoView hg38]
Genome Data Viewer NCBIANLN [Mapview hg19]  
OMIM616027   616032   
Gene and transcription
Genbank (Entrez)AF273437 AK001468 AK001472 AK023208 AK094574
RefSeq transcript (Entrez)NM_001284301 NM_001284302 NM_018685
Consensus coding sequences : CCDS (NCBI)ANLN
Gene ExpressionANLN [ NCBI-GEO ]   ANLN [ EBI - ARRAY_EXPRESS ]   ANLN [ SEEK ]   ANLN [ MEM ]
Gene Expression Viewer (FireBrowse)ANLN [ Firebrowse - Broad ]
GenevisibleExpression of ANLN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54443
GTEX Portal (Tissue expression)ANLN
Human Protein AtlasENSG00000011426-ANLN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQW6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQW6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQW6
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)AHD    Anillin_N    PH-like_dom_sf    PH_Anillin    PH_domain   
Domain families : Pfam (Sanger)Anillin (PF08174)    Anillin_N (PF16018)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam08174    pfam16018    pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)ANLN
PDB (RSDB)2Y7B    4XH3    4XOI   
PDB Europe2Y7B    4XH3    4XOI   
PDB (PDBSum)2Y7B    4XH3    4XOI   
PDB (IMB)2Y7B    4XH3    4XOI   
Structural Biology KnowledgeBase2Y7B    4XH3    4XOI   
SCOP (Structural Classification of Proteins)2Y7B    4XH3    4XOI   
CATH (Classification of proteins structures)2Y7B    4XH3    4XOI   
AlphaFold pdb e-kbQ9NQW6   
Human Protein Atlas [tissue]ENSG00000011426-ANLN [tissue]
Protein Interaction databases
IntAct (EBI)Q9NQW6
Ontologies - Pathways
Ontology : AmiGOmitotic cytokinesis  mitotic cytokinesis  actomyosin contractile ring assembly  septin ring assembly  actin binding  nucleoplasm  actomyosin contractile ring  actomyosin contractile ring  regulation of exit from mitosis  actin cytoskeleton  midbody  septin ring organization  bleb  cadherin binding  glomerular visceral epithelial cell migration  cell cortex region  positive regulation of bleb assembly  
Ontology : EGO-EBImitotic cytokinesis  mitotic cytokinesis  actomyosin contractile ring assembly  septin ring assembly  actin binding  nucleoplasm  actomyosin contractile ring  actomyosin contractile ring  regulation of exit from mitosis  actin cytoskeleton  midbody  septin ring organization  bleb  cadherin binding  glomerular visceral epithelial cell migration  cell cortex region  positive regulation of bleb assembly  
NDEx NetworkANLN
Atlas of Cancer Signalling NetworkANLN
Wikipedia pathwaysANLN
Orthology - Evolution
GeneTree (enSembl)ENSG00000011426
Phylogenetic Trees/Animal Genes : TreeFamANLN
Homologs : HomoloGeneANLN
Homology/Alignments : Family Browser (UCSC)ANLN
Gene fusions - Rearrangements
Fusion : MitelmanANLN::EEPD1 [7p14.2/7p14.2]  
Fusion : MitelmanANLN::POU6F2 [7p14.2/7p14.1]  
Fusion : QuiverANLN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANLN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANLN
Exome Variant ServerANLN
GNOMAD BrowserENSG00000011426
Varsome BrowserANLN
ACMGANLN variants
Genomic Variants (DGV)ANLN [DGVbeta]
DECIPHERANLN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANLN 
ICGC Data PortalANLN 
TCGA Data PortalANLN 
Broad Tumor PortalANLN
OASIS PortalANLN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANLN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DANLN
Mutations and Diseases : HGMDANLN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)ANLN
DoCM (Curated mutations)ANLN
CIViC (Clinical Interpretations of Variants in Cancer)ANLN
NCG (London)ANLN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
OMIM616027    616032   
Genetic Testing Registry ANLN
NextProtQ9NQW6 [Medical]
Target ValidationANLN
Huge Navigator ANLN [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDANLN
Pharm GKB GenePA24809
Clinical trialANLN
DataMed IndexANLN
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:12:31 CEST 2021

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