ANO1 (anoctamin 1)

2003-11-01  

Identity

HGNC
LOCATION
11q13.3
LOCUSID
ALIAS
DOG1,ORAOV2,TAOS2,TMEM16A
FUSION GENES

Other Information

Locus ID:

NCBI: 55107
MIM: 610108
HGNC: 21625
Ensembl: ENSG00000131620

Variants:

dbSNP: 55107
ClinVar: 55107
TCGA: ENSG00000131620
COSMIC: ANO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131620ENST00000316296Q5XXA6
ENSG00000131620ENST00000355303Q5XXA6
ENSG00000131620ENST00000530480H0YDD9
ENSG00000131620ENST00000530676Q5XXA6
ENSG00000131620ENST00000531300E9PS90
ENSG00000131620ENST00000531349E9PNA7
ENSG00000131620ENST00000531604E9PP68

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187723982008TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity.486
196871222009Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles.162
193721022009Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract.153
210842982011TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.147
225645242012TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.103
198198742009Regulation of TMEM16A chloride channel properties by alternative splicing.100
234311532013Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.96
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
196060132009DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases.73
196543232009TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.67

Citation

Dessen P

ANO1 (anoctamin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42588/ano1