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ANO1 (anoctamin 1)

Identity

Alias_namesORAOV2
TMEM16A
oral cancer overexpressed 2
transmembrane protein 16A
anoctamin 1, calcium activated chloride channel
Alias_symbol (synonym)TAOS2
FLJ10261
DOG1
Other alias
HGNC (Hugo) ANO1
LocusID (NCBI) 55107
Atlas_Id 42588
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 70078302 and ends at 70189546 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANO1 (11q13.3) / ABCC11 (16q12.1)ANO1 (11q13.3) / ABHD15 (17q11.2)ANO1 (11q13.3) / CYP2R1 (11p15.2)
ANO1 (11q13.3) / UNC5D (8p12)CTTN (11q13.3) / ANO1 (11q13.3)DGCR2 (22q11.21) / ANO1 (11q13.3)
RNF121 (11q13.4) / ANO1 (11q13.3)SLC22A15 (1p13.1) / ANO1 (11q13.3)ANO1 11q13.3 / ABCC11 16q12.1
ANO1 11q13.3 / ABHD15 17q11.2ANO1 11q13.3 / CYP2R1 11p15.2ANO1 11q13.3 / UNC5D 8p12
CTTN 11q13.3 / ANO1 11q13.3DGCR2 22q11.21 / ANO1 11q13.3RNF121 11q13.4 / ANO1 11q13.3
SLC22A15 1p13.1 / ANO1 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Soft Tissues: Desmoid-type fibromatosis
Inflammatory fibroid polyps


External links

Nomenclature
HGNC (Hugo)ANO1   21625
Cards
Entrez_Gene (NCBI)ANO1  55107  anoctamin 1
AliasesDOG1; ORAOV2; TAOS2; TMEM16A
GeneCards (Weizmann)ANO1
Ensembl hg19 (Hinxton)ENSG00000131620 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131620 [Gene_View]  chr11:70078302-70189546 [Contig_View]  ANO1 [Vega]
ICGC DataPortalENSG00000131620
TCGA cBioPortalANO1
AceView (NCBI)ANO1
Genatlas (Paris)ANO1
WikiGenes55107
SOURCE (Princeton)ANO1
Genetics Home Reference (NIH)ANO1
Genomic and cartography
GoldenPath hg38 (UCSC)ANO1  -     chr11:70078302-70189546 +  11q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANO1  -     11q13.3   [Description]    (hg19-Feb_2009)
EnsemblANO1 - 11q13.3 [CytoView hg19]  ANO1 - 11q13.3 [CytoView hg38]
Mapping of homologs : NCBIANO1 [Mapview hg19]  ANO1 [Mapview hg38]
OMIM610108   
Gene and transcription
Genbank (Entrez)AB845669 AI694083 AK001123 AK097619 AK293088
RefSeq transcript (Entrez)NM_018043
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANO1
Cluster EST : UnigeneHs.503074 [ NCBI ]
CGAP (NCI)Hs.503074
Alternative Splicing GalleryENSG00000131620
Gene ExpressionANO1 [ NCBI-GEO ]   ANO1 [ EBI - ARRAY_EXPRESS ]   ANO1 [ SEEK ]   ANO1 [ MEM ]
Gene Expression Viewer (FireBrowse)ANO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55107
GTEX Portal (Tissue expression)ANO1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5XXA6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5XXA6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5XXA6
Splice isoforms : SwissVarQ5XXA6
PhosPhoSitePlusQ5XXA6
Domains : Interpro (EBI)Anoct_dimer    Anoctamin   
Domain families : Pfam (Sanger)Anoct_dimer (PF16178)    Anoctamin (PF04547)   
Domain families : Pfam (NCBI)pfam16178    pfam04547   
Conserved Domain (NCBI)ANO1
DMDM Disease mutations55107
Blocks (Seattle)ANO1
SuperfamilyQ5XXA6
Human Protein AtlasENSG00000131620
Peptide AtlasQ5XXA6
HPRD18202
IPIIPI00395839   IPI00873502   IPI00384668   IPI00922381   IPI01013933   IPI01011767   IPI00984391   IPI00976925   IPI00985036   IPI00983739   
Protein Interaction databases
DIP (DOE-UCLA)Q5XXA6
IntAct (EBI)Q5XXA6
FunCoupENSG00000131620
BioGRIDANO1
STRING (EMBL)ANO1
ZODIACANO1
Ontologies - Pathways
QuickGOQ5XXA6
Ontology : AmiGOcalcium activated cation channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  voltage-gated chloride channel activity  chloride channel activity  protein binding  cytoplasm  plasma membrane  plasma membrane  plasma membrane  cation transport  chloride transport  chloride transport  phospholipase C-activating G-protein coupled receptor signaling pathway  multicellular organism development  iodide transmembrane transporter activity  iodide transport  apical plasma membrane  ion transmembrane transport  cellular response to heat  chloride channel complex  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of insulin secretion involved in cellular response to glucose stimulus  protein dimerization activity  detection of temperature stimulus involved in sensory perception of pain  extracellular exosome  cation transmembrane transport  chloride transmembrane transport  regulation of anion transmembrane transport  
Ontology : EGO-EBIcalcium activated cation channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  voltage-gated chloride channel activity  chloride channel activity  protein binding  cytoplasm  plasma membrane  plasma membrane  plasma membrane  cation transport  chloride transport  chloride transport  phospholipase C-activating G-protein coupled receptor signaling pathway  multicellular organism development  iodide transmembrane transporter activity  iodide transport  apical plasma membrane  ion transmembrane transport  cellular response to heat  chloride channel complex  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of insulin secretion involved in cellular response to glucose stimulus  protein dimerization activity  detection of temperature stimulus involved in sensory perception of pain  extracellular exosome  cation transmembrane transport  chloride transmembrane transport  regulation of anion transmembrane transport  
NDEx NetworkANO1
Atlas of Cancer Signalling NetworkANO1
Wikipedia pathwaysANO1
Orthology - Evolution
OrthoDB55107
GeneTree (enSembl)ENSG00000131620
Phylogenetic Trees/Animal Genes : TreeFamANO1
HOVERGENQ5XXA6
HOGENOMQ5XXA6
Homologs : HomoloGeneANO1
Homology/Alignments : Family Browser (UCSC)ANO1
Gene fusions - Rearrangements
Fusion : MitelmanANO1/ABCC11 [11q13.3/16q12.1]  
Fusion : MitelmanANO1/ABHD15 [11q13.3/17q11.2]  [t(11;17)(q13;q11)]  
Fusion : MitelmanANO1/CYP2R1 [11q13.3/11p15.2]  [t(11;11)(p15;q13)]  
Fusion : MitelmanANO1/UNC5D [11q13.3/8p12]  [t(8;11)(p12;q13)]  
Fusion : MitelmanCTTN/ANO1 [11q13.3/11q13.3]  [dup(11)(q13q13)]  [t(11;11)(q13;q13)]  
Fusion : MitelmanDGCR2/ANO1 [22q11.21/11q13.3]  [t(11;22)(q13;q11)]  
Fusion : MitelmanRNF121/ANO1 [11q13.4/11q13.3]  [t(11;11)(q13;q13)]  
Fusion : MitelmanSLC22A15/ANO1 [1p13.1/11q13.3]  [t(1;11)(p13;q13)]  
Fusion: TCGAANO1 11q13.3 ABCC11 16q12.1 BRCA
Fusion: TCGAANO1 11q13.3 ABHD15 17q11.2 BRCA
Fusion: TCGAANO1 11q13.3 CYP2R1 11p15.2 BRCA
Fusion: TCGAANO1 11q13.3 UNC5D 8p12 BRCA
Fusion: TCGACTTN 11q13.3 ANO1 11q13.3 BRCA
Fusion: TCGADGCR2 22q11.21 ANO1 11q13.3 HNSC
Fusion: TCGARNF121 11q13.4 ANO1 11q13.3 BRCA
Fusion: TCGASLC22A15 1p13.1 ANO1 11q13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANO1
dbVarANO1
ClinVarANO1
1000_GenomesANO1 
Exome Variant ServerANO1
ExAC (Exome Aggregation Consortium)ANO1 (select the gene name)
Genetic variants : HAPMAP55107
Genomic Variants (DGV)ANO1 [DGVbeta]
DECIPHERANO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANO1 
Mutations
ICGC Data PortalANO1 
TCGA Data PortalANO1 
Broad Tumor PortalANO1
OASIS PortalANO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANO1
DgiDB (Drug Gene Interaction Database)ANO1
DoCM (Curated mutations)ANO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANO1 (select a term)
intoGenANO1
Cancer3DANO1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610108   
Orphanet
MedgenANO1
Genetic Testing Registry ANO1
NextProtQ5XXA6 [Medical]
TSGene55107
GENETestsANO1
Target ValidationANO1
Huge Navigator ANO1 [HugePedia]
snp3D : Map Gene to Disease55107
BioCentury BCIQANO1
ClinGenANO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55107
Chemical/Pharm GKB GenePA164715378
Clinical trialANO1
Miscellaneous
canSAR (ICR)ANO1 (select the gene name)
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANO1
EVEXANO1
GoPubMedANO1
iHOPANO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:46:49 CEST 2017

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