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ANO2 (anoctamin 2)

Identity

Alias_namesC12orf3
TMEM16B
chromosome 12 open reading frame 3
transmembrane protein 16B
anoctamin 2, calcium activated chloride channel
Other alias
HGNC (Hugo) ANO2
LocusID (NCBI) 57101
Atlas_Id 54128
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 5562651 and ends at 5945259 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANO2 (12p13.31) / ANO2 (12p13.31)ANO2 (12p13.31) / FBXL14 (12p13.33)ERC1 (12p13.33) / ANO2 (12p13.31)
ITPR2 (12p12.1) / ANO2 (12p13.31)KDM5A (12p13.33) / ANO2 (12p13.31)ITPR2 12p12.1 / ANO2 12p13.31
KDM5A 12p13.33 / ANO2 12p13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)ANO2   1183
Cards
Entrez_Gene (NCBI)ANO2  57101  anoctamin 2
AliasesC12orf3; TMEM16B
GeneCards (Weizmann)ANO2
Ensembl hg19 (Hinxton)ENSG00000047617 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000047617 [Gene_View]  chr12:5562651-5945259 [Contig_View]  ANO2 [Vega]
ICGC DataPortalENSG00000047617
TCGA cBioPortalANO2
AceView (NCBI)ANO2
Genatlas (Paris)ANO2
WikiGenes57101
SOURCE (Princeton)ANO2
Genetics Home Reference (NIH)ANO2
Genomic and cartography
GoldenPath hg38 (UCSC)ANO2  -     chr12:5562651-5945259 -  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANO2  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblANO2 - 12p13.31 [CytoView hg19]  ANO2 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBIANO2 [Mapview hg19]  ANO2 [Mapview hg38]
OMIM610109   
Gene and transcription
Genbank (Entrez)AB593159 AJ272204 AK024010 AL137419 BC152768
RefSeq transcript (Entrez)NM_001278596 NM_001278597 NM_020373
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANO2
Cluster EST : UnigeneHs.148970 [ NCBI ]
CGAP (NCI)Hs.148970
Alternative Splicing GalleryENSG00000047617
Gene ExpressionANO2 [ NCBI-GEO ]   ANO2 [ EBI - ARRAY_EXPRESS ]   ANO2 [ SEEK ]   ANO2 [ MEM ]
Gene Expression Viewer (FireBrowse)ANO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57101
GTEX Portal (Tissue expression)ANO2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQ90   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQ90  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQ90
Splice isoforms : SwissVarQ9NQ90
PhosPhoSitePlusQ9NQ90
Domains : Interpro (EBI)Anoct_dimer    Anoctamin   
Domain families : Pfam (Sanger)Anoct_dimer (PF16178)    Anoctamin (PF04547)   
Domain families : Pfam (NCBI)pfam16178    pfam04547   
Conserved Domain (NCBI)ANO2
DMDM Disease mutations57101
Blocks (Seattle)ANO2
SuperfamilyQ9NQ90
Human Protein AtlasENSG00000047617
Peptide AtlasQ9NQ90
HPRD11634
IPIIPI00033553   IPI00479837   IPI00973586   IPI01013889   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQ90
IntAct (EBI)Q9NQ90
FunCoupENSG00000047617
BioGRIDANO2
STRING (EMBL)ANO2
ZODIACANO2
Ontologies - Pathways
QuickGOQ9NQ90
Ontology : AmiGOintracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  nucleoplasm  plasma membrane  plasma membrane  plasma membrane  ion transmembrane transport  chloride channel complex  protein homodimerization activity  protein heterodimerization activity  non-motile cilium  chloride transmembrane transport  
Ontology : EGO-EBIintracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  nucleoplasm  plasma membrane  plasma membrane  plasma membrane  ion transmembrane transport  chloride channel complex  protein homodimerization activity  protein heterodimerization activity  non-motile cilium  chloride transmembrane transport  
NDEx NetworkANO2
Atlas of Cancer Signalling NetworkANO2
Wikipedia pathwaysANO2
Orthology - Evolution
OrthoDB57101
GeneTree (enSembl)ENSG00000047617
Phylogenetic Trees/Animal Genes : TreeFamANO2
HOVERGENQ9NQ90
HOGENOMQ9NQ90
Homologs : HomoloGeneANO2
Homology/Alignments : Family Browser (UCSC)ANO2
Gene fusions - Rearrangements
Fusion : MitelmanANO2/FBXL14 [12p13.31/12p13.33]  
Fusion : MitelmanERC1/ANO2 [12p13.33/12p13.31]  [inv(12)(p13p13)]  
Fusion : MitelmanITPR2/ANO2 [12p12.1/12p13.31]  [t(12;12)(p11;p13)]  
Fusion : MitelmanKDM5A/ANO2 [12p13.33/12p13.31]  [t(12;12)(p13;p13)]  
Fusion: TCGAITPR2 12p12.1 ANO2 12p13.31 BRCA
Fusion: TCGAKDM5A 12p13.33 ANO2 12p13.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANO2
dbVarANO2
ClinVarANO2
1000_GenomesANO2 
Exome Variant ServerANO2
ExAC (Exome Aggregation Consortium)ANO2 (select the gene name)
Genetic variants : HAPMAP57101
Genomic Variants (DGV)ANO2 [DGVbeta]
DECIPHERANO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANO2 
Mutations
ICGC Data PortalANO2 
TCGA Data PortalANO2 
Broad Tumor PortalANO2
OASIS PortalANO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANO2
DgiDB (Drug Gene Interaction Database)ANO2
DoCM (Curated mutations)ANO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANO2 (select a term)
intoGenANO2
Cancer3DANO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610109   
Orphanet
MedgenANO2
Genetic Testing Registry ANO2
NextProtQ9NQ90 [Medical]
TSGene57101
GENETestsANO2
Target ValidationANO2
Huge Navigator ANO2 [HugePedia]
snp3D : Map Gene to Disease57101
BioCentury BCIQANO2
ClinGenANO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57101
Chemical/Pharm GKB GenePA25504
Clinical trialANO2
Miscellaneous
canSAR (ICR)ANO2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANO2
EVEXANO2
GoPubMedANO2
iHOPANO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:55:01 CEST 2017

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