Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ANO6 (anoctamin 6)

Identity

Alias_namesTMEM16F
transmembrane protein 16F
Alias_symbol (synonym)DKFZp313M0720
Other aliasBDPLT7
SCTS
HGNC (Hugo) ANO6
LocusID (NCBI) 196527
Atlas_Id 55680
Location 12q12  [Link to chromosome band 12q12]
Location_base_pair Starts at 45215987 and ends at 45432351 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANO6 (12q12) / ANO6 (12q12)ANO6 (12q12) / FAM129A (1q25.3)ANO6 (12q12) / IAPP (12p12.1)
ANO6 (12q12) / PRKAB2 (1q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(p12;q12) ANO6/IAPP


External links

Nomenclature
HGNC (Hugo)ANO6   25240
LRG (Locus Reference Genomic)LRG_877
Cards
Entrez_Gene (NCBI)ANO6  196527  anoctamin 6
AliasesBDPLT7; SCTS; TMEM16F
GeneCards (Weizmann)ANO6
Ensembl hg19 (Hinxton)ENSG00000177119 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177119 [Gene_View]  ENSG00000177119 [Sequence]  chr12:45215987-45432351 [Contig_View]  ANO6 [Vega]
ICGC DataPortalENSG00000177119
TCGA cBioPortalANO6
AceView (NCBI)ANO6
Genatlas (Paris)ANO6
WikiGenes196527
SOURCE (Princeton)ANO6
Genetics Home Reference (NIH)ANO6
Genomic and cartography
GoldenPath hg38 (UCSC)ANO6  -     chr12:45215987-45432351 +  12q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANO6  -     12q12   [Description]    (hg19-Feb_2009)
EnsemblANO6 - 12q12 [CytoView hg19]  ANO6 - 12q12 [CytoView hg38]
Mapping of homologs : NCBIANO6 [Mapview hg19]  ANO6 [Mapview hg38]
OMIM262890   608663   
Gene and transcription
Genbank (Entrez)AA332109 AK095979 AK126409 AK302819 AK303996
RefSeq transcript (Entrez)NM_001025356 NM_001142678 NM_001142679 NM_001142680 NM_001204803
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANO6
Cluster EST : UnigeneHs.505339 [ NCBI ]
CGAP (NCI)Hs.505339
Alternative Splicing GalleryENSG00000177119
Gene ExpressionANO6 [ NCBI-GEO ]   ANO6 [ EBI - ARRAY_EXPRESS ]   ANO6 [ SEEK ]   ANO6 [ MEM ]
Gene Expression Viewer (FireBrowse)ANO6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)196527
GTEX Portal (Tissue expression)ANO6
Human Protein AtlasENSG00000177119-ANO6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4KMQ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4KMQ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4KMQ2
Splice isoforms : SwissVarQ4KMQ2
PhosPhoSitePlusQ4KMQ2
Domains : Interpro (EBI)Anoct_dimer    Anoctamin    Anoctamin-6   
Domain families : Pfam (Sanger)Anoct_dimer (PF16178)    Anoctamin (PF04547)   
Domain families : Pfam (NCBI)pfam16178    pfam04547   
Conserved Domain (NCBI)ANO6
DMDM Disease mutations196527
Blocks (Seattle)ANO6
SuperfamilyQ4KMQ2
Human Protein Atlas [tissue]ENSG00000177119-ANO6 [tissue]
Peptide AtlasQ4KMQ2
HPRD18746
IPIIPI00151710   IPI00798252   IPI01021575   IPI00917081   IPI00910110   IPI00790445   
Protein Interaction databases
DIP (DOE-UCLA)Q4KMQ2
IntAct (EBI)Q4KMQ2
FunCoupENSG00000177119
BioGRIDANO6
STRING (EMBL)ANO6
ZODIACANO6
Ontologies - Pathways
QuickGOQ4KMQ2
Ontology : AmiGOdendritic cell chemotaxis  activation of blood coagulation via clotting cascade  calcium activated cation channel activity  calcium activated cation channel activity  calcium activated cation channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  voltage-gated ion channel activity  voltage-gated chloride channel activity  protein binding  intracellular  cytosol  plasma membrane  plasma membrane  cation transport  chloride transport  lipid transport  blood coagulation  cell surface  membrane  phospholipid scrambling  phospholipid scrambling  phospholipid scramblase activity  positive regulation of bone mineralization  bleb assembly  ion transmembrane transport  chloride channel complex  positive regulation of ion transmembrane transport  specific granule membrane  purinergic nucleotide receptor signaling pathway  bone mineralization involved in bone maturation  sodium ion transmembrane transport  protein homodimerization activity  positive regulation of apoptotic process  neutrophil degranulation  negative regulation of cell volume  pore complex assembly  positive regulation of phagocytosis, engulfment  calcium activated phosphatidylserine scrambling  calcium activated phosphatidylcholine scrambling  calcium activated galactosylceramide scrambling  extracellular exosome  calcium ion transmembrane transport  tertiary granule membrane  positive regulation of monocyte chemotaxis  phosphatidylserine exposure on blood platelet  chloride transmembrane transport  positive regulation of potassium ion export across plasma membrane  positive regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIdendritic cell chemotaxis  activation of blood coagulation via clotting cascade  calcium activated cation channel activity  calcium activated cation channel activity  calcium activated cation channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  intracellular calcium activated chloride channel activity  voltage-gated ion channel activity  voltage-gated chloride channel activity  protein binding  intracellular  cytosol  plasma membrane  plasma membrane  cation transport  chloride transport  lipid transport  blood coagulation  cell surface  membrane  phospholipid scrambling  phospholipid scrambling  phospholipid scramblase activity  positive regulation of bone mineralization  bleb assembly  ion transmembrane transport  chloride channel complex  positive regulation of ion transmembrane transport  specific granule membrane  purinergic nucleotide receptor signaling pathway  bone mineralization involved in bone maturation  sodium ion transmembrane transport  protein homodimerization activity  positive regulation of apoptotic process  neutrophil degranulation  negative regulation of cell volume  pore complex assembly  positive regulation of phagocytosis, engulfment  calcium activated phosphatidylserine scrambling  calcium activated phosphatidylcholine scrambling  calcium activated galactosylceramide scrambling  extracellular exosome  calcium ion transmembrane transport  tertiary granule membrane  positive regulation of monocyte chemotaxis  phosphatidylserine exposure on blood platelet  chloride transmembrane transport  positive regulation of potassium ion export across plasma membrane  positive regulation of endothelial cell apoptotic process  
NDEx NetworkANO6
Atlas of Cancer Signalling NetworkANO6
Wikipedia pathwaysANO6
Orthology - Evolution
OrthoDB196527
GeneTree (enSembl)ENSG00000177119
Phylogenetic Trees/Animal Genes : TreeFamANO6
HOVERGENQ4KMQ2
HOGENOMQ4KMQ2
Homologs : HomoloGeneANO6
Homology/Alignments : Family Browser (UCSC)ANO6
Gene fusions - Rearrangements
Fusion : QuiverANO6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANO6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANO6
dbVarANO6
ClinVarANO6
1000_GenomesANO6 
Exome Variant ServerANO6
ExAC (Exome Aggregation Consortium)ENSG00000177119
GNOMAD BrowserENSG00000177119
Varsome BrowserANO6
Genetic variants : HAPMAP196527
Genomic Variants (DGV)ANO6 [DGVbeta]
DECIPHERANO6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANO6 
Mutations
ICGC Data PortalANO6 
TCGA Data PortalANO6 
Broad Tumor PortalANO6
OASIS PortalANO6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANO6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANO6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANO6
DgiDB (Drug Gene Interaction Database)ANO6
DoCM (Curated mutations)ANO6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANO6 (select a term)
intoGenANO6
Cancer3DANO6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM262890    608663   
Orphanet7521   
DisGeNETANO6
MedgenANO6
Genetic Testing Registry ANO6
NextProtQ4KMQ2 [Medical]
TSGene196527
GENETestsANO6
Target ValidationANO6
Huge Navigator ANO6 [HugePedia]
snp3D : Map Gene to Disease196527
BioCentury BCIQANO6
ClinGenANO6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD196527
Chemical/Pharm GKB GenePA164715690
Clinical trialANO6
Miscellaneous
canSAR (ICR)ANO6 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANO6
EVEXANO6
GoPubMedANO6
iHOPANO6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:51:17 CET 2018

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