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ANPEP (alanyl aminopeptidase, membrane)

Identity

Alias_namesCD13
PEPN
alanyl (membrane) aminopeptidase
Alias_symbol (synonym)LAP1
gp150
p150
Other aliasAPN
GP150
P150
HGNC (Hugo) ANPEP
LocusID (NCBI) 290
Atlas_Id 651
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 90328126 and ends at 90358072 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANPEP (15q26.1) / ANPEP (15q26.1)ANPEP (15q26.1) / AP3S2 (15q26.1)CPT1A (11q13.3) / ANPEP (15q26.1)
CUX1 (7q22.1) / ANPEP (15q26.1)CPT1A 11q13.3 / ANPEP 15q26.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ANPEP   500
Cards
Entrez_Gene (NCBI)ANPEP  290  alanyl aminopeptidase, membrane
AliasesAPN; CD13; GP150; LAP1; 
P150; PEPN
GeneCards (Weizmann)ANPEP
Ensembl hg19 (Hinxton)ENSG00000166825 [Gene_View]  chr15:90328126-90358072 [Contig_View]  ANPEP [Vega]
Ensembl hg38 (Hinxton)ENSG00000166825 [Gene_View]  chr15:90328126-90358072 [Contig_View]  ANPEP [Vega]
ICGC DataPortalENSG00000166825
TCGA cBioPortalANPEP
AceView (NCBI)ANPEP
Genatlas (Paris)ANPEP
WikiGenes290
SOURCE (Princeton)ANPEP
Genetics Home Reference (NIH)ANPEP
Genomic and cartography
GoldenPath hg19 (UCSC)ANPEP  -     chr15:90328126-90358072 -  15q26.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ANPEP  -     15q26.1   [Description]    (hg38-Dec_2013)
EnsemblANPEP - 15q26.1 [CytoView hg19]  ANPEP - 15q26.1 [CytoView hg38]
Mapping of homologs : NCBIANPEP [Mapview hg19]  ANPEP [Mapview hg38]
OMIM151530   
Gene and transcription
Genbank (Entrez)AB209918 AK298134 AK298242 AK298339 AK300946
RefSeq transcript (Entrez)NM_001150
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929399
Consensus coding sequences : CCDS (NCBI)ANPEP
Cluster EST : UnigeneHs.1239 [ NCBI ]
CGAP (NCI)Hs.1239
Alternative Splicing GalleryENSG00000166825
Gene ExpressionANPEP [ NCBI-GEO ]   ANPEP [ EBI - ARRAY_EXPRESS ]   ANPEP [ SEEK ]   ANPEP [ MEM ]
Gene Expression Viewer (FireBrowse)ANPEP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)290
GTEX Portal (Tissue expression)ANPEP
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15144   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15144  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15144
Splice isoforms : SwissVarP15144
Catalytic activity : Enzyme3.4.11.2 [ Enzyme-Expasy ]   3.4.11.23.4.11.2 [ IntEnz-EBI ]   3.4.11.2 [ BRENDA ]   3.4.11.2 [ KEGG ]   
PhosPhoSitePlusP15144
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ERAP1-like_C_dom    Peptidase_M1    Peptidase_M1_N   
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
Conserved Domain (NCBI)ANPEP
DMDM Disease mutations290
Blocks (Seattle)ANPEP
PDB (SRS)4FYQ    4FYR    4FYS    4FYT   
PDB (PDBSum)4FYQ    4FYR    4FYS    4FYT   
PDB (IMB)4FYQ    4FYR    4FYS    4FYT   
PDB (RSDB)4FYQ    4FYR    4FYS    4FYT   
Structural Biology KnowledgeBase4FYQ    4FYR    4FYS    4FYT   
SCOP (Structural Classification of Proteins)4FYQ    4FYR    4FYS    4FYT   
CATH (Classification of proteins structures)4FYQ    4FYR    4FYS    4FYT   
SuperfamilyP15144
Human Protein AtlasENSG00000166825
Peptide AtlasP15144
HPRD01055
IPIIPI00221224   
Protein Interaction databases
DIP (DOE-UCLA)P15144
IntAct (EBI)P15144
FunCoupENSG00000166825
BioGRIDANPEP
STRING (EMBL)ANPEP
ZODIACANPEP
Ontologies - Pathways
QuickGOP15144
Ontology : AmiGOangiogenesis  virus receptor activity  aminopeptidase activity  receptor activity  extracellular space  lysosomal membrane  endoplasmic reticulum-Golgi intermediate compartment  cytosol  integral component of plasma membrane  proteolysis  cellular aromatic compound metabolic process  metallopeptidase activity  zinc ion binding  external side of plasma membrane  vesicle membrane  cell differentiation  vesicle lumen  negative regulation of renal sodium excretion  peptide binding  peptide catabolic process  viral entry into host cell  metalloaminopeptidase activity  extracellular exosome  
Ontology : EGO-EBIangiogenesis  virus receptor activity  aminopeptidase activity  receptor activity  extracellular space  lysosomal membrane  endoplasmic reticulum-Golgi intermediate compartment  cytosol  integral component of plasma membrane  proteolysis  cellular aromatic compound metabolic process  metallopeptidase activity  zinc ion binding  external side of plasma membrane  vesicle membrane  cell differentiation  vesicle lumen  negative regulation of renal sodium excretion  peptide binding  peptide catabolic process  viral entry into host cell  metalloaminopeptidase activity  extracellular exosome  
Pathways : BIOCARTADendritic cells in regulating TH1 and TH2 Development [Genes]    SARS Coronavirus Protease [Genes]   
Pathways : KEGGGlutathione metabolism    Renin-angiotensin system    Hematopoietic cell lineage   
NDEx NetworkANPEP
Atlas of Cancer Signalling NetworkANPEP
Wikipedia pathwaysANPEP
Orthology - Evolution
OrthoDB290
GeneTree (enSembl)ENSG00000166825
Phylogenetic Trees/Animal Genes : TreeFamANPEP
HOVERGENP15144
HOGENOMP15144
Homologs : HomoloGeneANPEP
Homology/Alignments : Family Browser (UCSC)ANPEP
Gene fusions - Rearrangements
Fusion : MitelmanCPT1A/ANPEP [11q13.3/15q26.1]  [t(11;15)(q13;q26)]  
Fusion: TCGACPT1A 11q13.3 ANPEP 15q26.1 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANPEP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANPEP
dbVarANPEP
ClinVarANPEP
1000_GenomesANPEP 
Exome Variant ServerANPEP
ExAC (Exome Aggregation Consortium)ANPEP (select the gene name)
Genetic variants : HAPMAP290
Genomic Variants (DGV)ANPEP [DGVbeta]
DECIPHER (Syndromes)15:90328126-90358072  ENSG00000166825
CONAN: Copy Number AnalysisANPEP 
Mutations
ICGC Data PortalANPEP 
TCGA Data PortalANPEP 
Broad Tumor PortalANPEP
OASIS PortalANPEP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANPEP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANPEP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANPEP
DgiDB (Drug Gene Interaction Database)ANPEP
DoCM (Curated mutations)ANPEP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANPEP (select a term)
intoGenANPEP
Cancer3DANPEP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151530   
Orphanet
MedgenANPEP
Genetic Testing Registry ANPEP
NextProtP15144 [Medical]
TSGene290
GENETestsANPEP
Huge Navigator ANPEP [HugePedia]
snp3D : Map Gene to Disease290
BioCentury BCIQANPEP
ClinGenANPEP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD290
Chemical/Pharm GKB GenePA24815
Clinical trialANPEP
Miscellaneous
canSAR (ICR)ANPEP (select the gene name)
Probes
Litterature
PubMed121 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANPEP
EVEXANPEP
GoPubMedANPEP
iHOPANPEP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:55:55 CET 2017

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