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ANPEP (alanyl aminopeptidase, membrane)

Identity

Alias (NCBI)APN
CD13
GP150
LAP1
P150
PEPN
HGNC (Hugo) ANPEP
HGNC Alias symbLAP1
gp150
p150
HGNC Alias nameaminopeptidase N
 aminopeptidase M
 microsomal aminopeptidase
 membrane alanyl aminopeptidase
HGNC Previous nameCD13
 PEPN
HGNC Previous namealanyl (membrane) aminopeptidase
LocusID (NCBI) 290
Atlas_Id 651
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 89784895 and ends at 89814852 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANPEP (15q26.1) / ANPEP (15q26.1)ANPEP (15q26.1) / AP3S2 (15q26.1)CPT1A (11q13.3) / ANPEP (15q26.1)
CUX1 (7q22.1) / ANPEP (15q26.1)CPT1A 11q13.3 / ANPEP 15q26.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)ANPEP   500
Cards
Entrez_Gene (NCBI)ANPEP    alanyl aminopeptidase, membrane
AliasesAPN; CD13; GP150; LAP1; 
P150; PEPN
GeneCards (Weizmann)ANPEP
Ensembl hg19 (Hinxton)ENSG00000166825 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166825 [Gene_View]  ENSG00000166825 [Sequence]  chr15:89784895-89814852 [Contig_View]  ANPEP [Vega]
ICGC DataPortalENSG00000166825
TCGA cBioPortalANPEP
AceView (NCBI)ANPEP
Genatlas (Paris)ANPEP
SOURCE (Princeton)ANPEP
Genetics Home Reference (NIH)ANPEP
Genomic and cartography
GoldenPath hg38 (UCSC)ANPEP  -     chr15:89784895-89814852 -  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ANPEP  -     15q26.1   [Description]    (hg19-Feb_2009)
GoldenPathANPEP - 15q26.1 [CytoView hg19]  ANPEP - 15q26.1 [CytoView hg38]
ImmunoBaseENSG00000166825
genome Data Viewer NCBIANPEP [Mapview hg19]  
OMIM151530   
Gene and transcription
Genbank (Entrez)AB209918 AK298134 AK298242 AK298339 AK300946
RefSeq transcript (Entrez)NM_001150 NM_001381923 NM_001381924
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ANPEP
Alternative Splicing GalleryENSG00000166825
Gene ExpressionANPEP [ NCBI-GEO ]   ANPEP [ EBI - ARRAY_EXPRESS ]   ANPEP [ SEEK ]   ANPEP [ MEM ]
Gene Expression Viewer (FireBrowse)ANPEP [ Firebrowse - Broad ]
GenevisibleExpression of ANPEP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)290
GTEX Portal (Tissue expression)ANPEP
Human Protein AtlasENSG00000166825-ANPEP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15144   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15144  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15144
Splice isoforms : SwissVarP15144
PhosPhoSitePlusP15144
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Aminopeptidase_N-like_N    ERAP1-like_C_dom    M1_APN-typ    Peptidase_M1    Peptidase_M1_dom   
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
Conserved Domain (NCBI)ANPEP
Blocks (Seattle)ANPEP
PDB (RSDB)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK    6U7E    6U7F    6U7G    7AEW   
PDB Europe4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK    6U7E    6U7F    6U7G    7AEW   
PDB (PDBSum)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK    6U7E    6U7F    6U7G    7AEW   
PDB (IMB)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK    6U7E    6U7F    6U7G    7AEW   
Structural Biology KnowledgeBase4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK    6U7E    6U7F    6U7G    7AEW   
SCOP (Structural Classification of Proteins)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK    6U7E    6U7F    6U7G    7AEW   
CATH (Classification of proteins structures)4FYQ    4FYR    4FYS    4FYT    5LHD    6ATK    6U7E    6U7F    6U7G    7AEW   
SuperfamilyP15144
Human Protein Atlas [tissue]ENSG00000166825-ANPEP [tissue]
Peptide AtlasP15144
HPRD01055
IPIIPI00221224   
Protein Interaction databases
DIP (DOE-UCLA)P15144
IntAct (EBI)P15144
BioGRIDANPEP
STRING (EMBL)ANPEP
ZODIACANPEP
Ontologies - Pathways
QuickGOP15144
Ontology : AmiGOangiogenesis  virus receptor activity  aminopeptidase activity  extracellular space  extracellular space  cytoplasm  lysosomal membrane  endoplasmic reticulum-Golgi intermediate compartment  plasma membrane  plasma membrane  plasma membrane  proteolysis  signal transduction  regulation of blood pressure  metallopeptidase activity  zinc ion binding  integral component of membrane  cell differentiation  secretory granule membrane  signaling receptor activity  peptide binding  peptide catabolic process  neutrophil degranulation  viral entry into host cell  metalloaminopeptidase activity  extracellular exosome  extracellular exosome  
Ontology : EGO-EBIangiogenesis  virus receptor activity  aminopeptidase activity  extracellular space  extracellular space  cytoplasm  lysosomal membrane  endoplasmic reticulum-Golgi intermediate compartment  plasma membrane  plasma membrane  plasma membrane  proteolysis  signal transduction  regulation of blood pressure  metallopeptidase activity  zinc ion binding  integral component of membrane  cell differentiation  secretory granule membrane  signaling receptor activity  peptide binding  peptide catabolic process  neutrophil degranulation  viral entry into host cell  metalloaminopeptidase activity  extracellular exosome  extracellular exosome  
Pathways : BIOCARTADendritic cells in regulating TH1 and TH2 Development [Genes]    SARS Coronavirus Protease [Genes]   
Pathways : KEGGGlutathione metabolism    Renin-angiotensin system    Hematopoietic cell lineage   
NDEx NetworkANPEP
Atlas of Cancer Signalling NetworkANPEP
Wikipedia pathwaysANPEP
Orthology - Evolution
OrthoDB290
GeneTree (enSembl)ENSG00000166825
Phylogenetic Trees/Animal Genes : TreeFamANPEP
HOGENOMP15144
Homologs : HomoloGeneANPEP
Homology/Alignments : Family Browser (UCSC)ANPEP
Gene fusions - Rearrangements
Fusion : MitelmanCPT1A/ANPEP [11q13.3/15q26.1]  
Fusion PortalCPT1A 11q13.3 ANPEP 15q26.1 KIRC
Fusion : QuiverANPEP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANPEP [hg38]
dbVarANPEP
ClinVarANPEP
MonarchANPEP
1000_GenomesANPEP 
Exome Variant ServerANPEP
GNOMAD BrowserENSG00000166825
Varsome BrowserANPEP
Genomic Variants (DGV)ANPEP [DGVbeta]
DECIPHERANPEP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisANPEP 
Mutations
ICGC Data PortalANPEP 
TCGA Data PortalANPEP 
Broad Tumor PortalANPEP
OASIS PortalANPEP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANPEP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DANPEP
Mutations and Diseases : HGMDANPEP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANPEP
DgiDB (Drug Gene Interaction Database)ANPEP
DoCM (Curated mutations)ANPEP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANPEP (select a term)
intoGenANPEP
Cancer3DANPEP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151530   
Orphanet
DisGeNETANPEP
MedgenANPEP
Genetic Testing Registry ANPEP
NextProtP15144 [Medical]
GENETestsANPEP
Target ValidationANPEP
Huge Navigator ANPEP [HugePedia]
ClinGenANPEP
Clinical trials, drugs, therapy
MyCancerGenomeANPEP
Protein Interactions : CTD
Pharm GKB GenePA24815
PharosP15144
Clinical trialANPEP
Miscellaneous
canSAR (ICR)ANPEP (select the gene name)
HarmonizomeANPEP
DataMed IndexANPEP
Probes
Litterature
PubMed153 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXANPEP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:11:01 CET 2021

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