Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ANXA2 (annexin A2)

Identity

Alias_namesANX2
ANX2L4
CAL1H
LPC2D
Alias_symbol (synonym)LIP2
Other aliasHEL-S-270
LPC2
P36
PAP-IV
HGNC (Hugo) ANXA2
LocusID (NCBI) 302
Atlas_Id 655
Location 15q22.2  [Link to chromosome band 15q22]
Location_base_pair Starts at 60639350 and ends at 60690185 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANXA2 (15q22.2) / ANXA2 (15q22.2)ANXA2 (15q22.2) / CREM (10p11.21)ANXA2 (15q22.2) / EZR (6q25.3)
ANXA2 (15q22.2) / ICE2 (15q22.2)ANXA2 (15q22.2) / RNF114 (20q13.13)ANXA2 (15q22.2) / RORA (15q22.2)
ANXA2 (15q22.2) / SPRR2A (1q21.3)C20orf196 (20p12.3) / ANXA2 (15q22.2)LHFPL2 (5q14.1) / ANXA2 (15q22.2)
PVT1 (8q24.21) / ANXA2 (15q22.2)RAB8B (15q22.2) / ANXA2 (15q22.2)SOD2 (6q25.3) / ANXA2 (15q22.2)
SPP1 (4q22.1) / ANXA2 (15q22.2)TRIP10 (19p13.3) / ANXA2 (15q22.2)ANXA2 15q22.2 / RNF114 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ANXA2   537
Cards
Entrez_Gene (NCBI)ANXA2  302  annexin A2
AliasesANX2; ANX2L4; CAL1H; HEL-S-270; 
LIP2; LPC2; LPC2D; P36; PAP-IV
GeneCards (Weizmann)ANXA2
Ensembl hg19 (Hinxton)ENSG00000182718 [Gene_View]  chr15:60639350-60690185 [Contig_View]  ANXA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182718 [Gene_View]  chr15:60639350-60690185 [Contig_View]  ANXA2 [Vega]
ICGC DataPortalENSG00000182718
TCGA cBioPortalANXA2
AceView (NCBI)ANXA2
Genatlas (Paris)ANXA2
WikiGenes302
SOURCE (Princeton)ANXA2
Genetics Home Reference (NIH)ANXA2
Genomic and cartography
GoldenPath hg19 (UCSC)ANXA2  -     chr15:60639350-60690185 -  15q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ANXA2  -     15q22.2   [Description]    (hg38-Dec_2013)
EnsemblANXA2 - 15q22.2 [CytoView hg19]  ANXA2 - 15q22.2 [CytoView hg38]
Mapping of homologs : NCBIANXA2 [Mapview hg19]  ANXA2 [Mapview hg38]
OMIM151740   
Gene and transcription
Genbank (Entrez)AA661718 AK092006 AK124427 AK222542 AK297923
RefSeq transcript (Entrez)NM_001002857 NM_001002858 NM_001136015 NM_004039
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)ANXA2
Cluster EST : UnigeneHs.511605 [ NCBI ]
CGAP (NCI)Hs.511605
Alternative Splicing GalleryENSG00000182718
Gene ExpressionANXA2 [ NCBI-GEO ]   ANXA2 [ EBI - ARRAY_EXPRESS ]   ANXA2 [ SEEK ]   ANXA2 [ MEM ]
Gene Expression Viewer (FireBrowse)ANXA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)302
GTEX Portal (Tissue expression)ANXA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07355   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07355  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07355
Splice isoforms : SwissVarP07355
PhosPhoSitePlusP07355
Domaine pattern : Prosite (Expaxy)ANNEXIN (PS00223)   
Domains : Interpro (EBI)Annexin    Annexin_repeat    Annexin_repeat_CS    AnnexinII   
Domain families : Pfam (Sanger)Annexin (PF00191)   
Domain families : Pfam (NCBI)pfam00191   
Domain families : Smart (EMBL)ANX (SM00335)  
Conserved Domain (NCBI)ANXA2
DMDM Disease mutations302
Blocks (Seattle)ANXA2
PDB (SRS)1W7B    1XJL    2HYU    2HYV    2HYW    4DRW    4FTG    4HRH   
PDB (PDBSum)1W7B    1XJL    2HYU    2HYV    2HYW    4DRW    4FTG    4HRH   
PDB (IMB)1W7B    1XJL    2HYU    2HYV    2HYW    4DRW    4FTG    4HRH   
PDB (RSDB)1W7B    1XJL    2HYU    2HYV    2HYW    4DRW    4FTG    4HRH   
Structural Biology KnowledgeBase1W7B    1XJL    2HYU    2HYV    2HYW    4DRW    4FTG    4HRH   
SCOP (Structural Classification of Proteins)1W7B    1XJL    2HYU    2HYV    2HYW    4DRW    4FTG    4HRH   
CATH (Classification of proteins structures)1W7B    1XJL    2HYU    2HYV    2HYW    4DRW    4FTG    4HRH   
SuperfamilyP07355
Human Protein AtlasENSG00000182718
Peptide AtlasP07355
HPRD01061
IPIIPI00455315   IPI00418169   IPI00903334   
Protein Interaction databases
DIP (DOE-UCLA)P07355
IntAct (EBI)P07355
FunCoupENSG00000182718
BioGRIDANXA2
STRING (EMBL)ANXA2
ZODIACANXA2
Ontologies - Pathways
QuickGOP07355
Ontology : AmiGOangiogenesis  ruffle  membrane raft assembly  positive regulation of protein phosphorylation  protease binding  negative regulation of receptor internalization  calcium ion binding  protein binding  calcium-dependent phospholipid binding  phosphatidylinositol-4,5-bisphosphate binding  basement membrane  extracellular space  nucleus  lysosomal membrane  endosome  early endosome  lipid particle  cytosol  plasma membrane  cell cortex  membrane budding  body fluid secretion  cytoskeletal protein binding  cell surface  membrane  basolateral plasma membrane  Rab GTPase binding  phospholipase A2 inhibitor activity  extrinsic component of plasma membrane  collagen fibril organization  midbody  receptor activator activity  extracellular matrix  positive regulation of vesicle fusion  late endosome membrane  vesicle  negative regulation of low-density lipoprotein particle receptor catabolic process  myelin sheath adaxonal region  osteoclast development  sarcolemma  melanosome  fibrinolysis  negative regulation of catalytic activity  negative regulation of catalytic activity  Schmidt-Lanterman incisure  macropinosome  S100 protein binding  poly(A) RNA binding  membrane raft  positive regulation of fibroblast proliferation  calcium-dependent protein binding  perinuclear region of cytoplasm  positive regulation of binding  protein heterotetramerization  extracellular exosome  protein targeting to plasma membrane  response to thyroid hormone  negative regulation of receptor binding  PCSK9-AnxA2 complex  positive regulation of receptor activity  
Ontology : EGO-EBIangiogenesis  ruffle  membrane raft assembly  positive regulation of protein phosphorylation  protease binding  negative regulation of receptor internalization  calcium ion binding  protein binding  calcium-dependent phospholipid binding  phosphatidylinositol-4,5-bisphosphate binding  basement membrane  extracellular space  nucleus  lysosomal membrane  endosome  early endosome  lipid particle  cytosol  plasma membrane  cell cortex  membrane budding  body fluid secretion  cytoskeletal protein binding  cell surface  membrane  basolateral plasma membrane  Rab GTPase binding  phospholipase A2 inhibitor activity  extrinsic component of plasma membrane  collagen fibril organization  midbody  receptor activator activity  extracellular matrix  positive regulation of vesicle fusion  late endosome membrane  vesicle  negative regulation of low-density lipoprotein particle receptor catabolic process  myelin sheath adaxonal region  osteoclast development  sarcolemma  melanosome  fibrinolysis  negative regulation of catalytic activity  negative regulation of catalytic activity  Schmidt-Lanterman incisure  macropinosome  S100 protein binding  poly(A) RNA binding  membrane raft  positive regulation of fibroblast proliferation  calcium-dependent protein binding  perinuclear region of cytoplasm  positive regulation of binding  protein heterotetramerization  extracellular exosome  protein targeting to plasma membrane  response to thyroid hormone  negative regulation of receptor binding  PCSK9-AnxA2 complex  positive regulation of receptor activity  
NDEx NetworkANXA2
Atlas of Cancer Signalling NetworkANXA2
Wikipedia pathwaysANXA2
Orthology - Evolution
OrthoDB302
GeneTree (enSembl)ENSG00000182718
Phylogenetic Trees/Animal Genes : TreeFamANXA2
HOVERGENP07355
HOGENOMP07355
Homologs : HomoloGeneANXA2
Homology/Alignments : Family Browser (UCSC)ANXA2
Gene fusions - Rearrangements
Fusion : MitelmanANXA2/RNF114 [15q22.2/20q13.13]  
Fusion : MitelmanANXA2/RORA [15q22.2/15q22.2]  [t(15;15)(q22;q22)]  
Fusion: TCGAANXA2 15q22.2 RNF114 20q13.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANXA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANXA2
dbVarANXA2
ClinVarANXA2
1000_GenomesANXA2 
Exome Variant ServerANXA2
ExAC (Exome Aggregation Consortium)ANXA2 (select the gene name)
Genetic variants : HAPMAP302
Genomic Variants (DGV)ANXA2 [DGVbeta]
DECIPHER (Syndromes)15:60639350-60690185  ENSG00000182718
CONAN: Copy Number AnalysisANXA2 
Mutations
ICGC Data PortalANXA2 
TCGA Data PortalANXA2 
Broad Tumor PortalANXA2
OASIS PortalANXA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANXA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANXA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANXA2
DgiDB (Drug Gene Interaction Database)ANXA2
DoCM (Curated mutations)ANXA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANXA2 (select a term)
intoGenANXA2
Cancer3DANXA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM151740   
Orphanet
MedgenANXA2
Genetic Testing Registry ANXA2
NextProtP07355 [Medical]
TSGene302
GENETestsANXA2
Huge Navigator ANXA2 [HugePedia]
snp3D : Map Gene to Disease302
BioCentury BCIQANXA2
ClinGenANXA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD302
Chemical/Pharm GKB GenePA24827
Clinical trialANXA2
Miscellaneous
canSAR (ICR)ANXA2 (select the gene name)
Probes
Litterature
PubMed375 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANXA2
EVEXANXA2
GoPubMedANXA2
iHOPANXA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:55:57 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.