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ANXA4 (annexin A4)

Identity

Alias_namesANX4
Other aliasHEL-S-274
P32.5
PAP-II
PIG28
PP4-X
ZAP36
HGNC (Hugo) ANXA4
LocusID (NCBI) 307
Atlas_Id 43816
Location 2p13.3  [Link to chromosome band 2p13]
Location_base_pair Starts at 69969106 and ends at 70053609 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ABL1 (9q34.12) / ANXA4 (2p13.3)ANXA4 (2p13.3) / ANXA4 (2p13.3)ANXA4 (2p13.3) / NUMB (14q24.2)
ANXA4 (2p13.3) / PKN1 (19p13.12)ANXA4 (2p13.3) / TMEM67 (8q22.1)DENND1A (9q33.3) / ANXA4 (2p13.3)
GMCL1 (2p13.3) / ANXA4 (2p13.3)MCEE (2p13.3) / ANXA4 (2p13.3)RBBP8 (18q11.2) / ANXA4 (2p13.3)
GMCL1 2p13.3 / ANXA4 2p13.3MCEE 2p13.3 / ANXA4 2p13.3RBBP8 18q11.2 / ANXA4 2p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ANXA4   542
Cards
Entrez_Gene (NCBI)ANXA4  307  annexin A4
AliasesANX4; HEL-S-274; P32.5; PAP-II; 
PIG28; PP4-X; ZAP36
GeneCards (Weizmann)ANXA4
Ensembl hg19 (Hinxton)ENSG00000196975 [Gene_View]  chr2:69969106-70053609 [Contig_View]  ANXA4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196975 [Gene_View]  chr2:69969106-70053609 [Contig_View]  ANXA4 [Vega]
ICGC DataPortalENSG00000196975
TCGA cBioPortalANXA4
AceView (NCBI)ANXA4
Genatlas (Paris)ANXA4
WikiGenes307
SOURCE (Princeton)ANXA4
Genetics Home Reference (NIH)ANXA4
Genomic and cartography
GoldenPath hg19 (UCSC)ANXA4  -     chr2:69969106-70053609 +  2p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ANXA4  -     2p13.3   [Description]    (hg38-Dec_2013)
EnsemblANXA4 - 2p13.3 [CytoView hg19]  ANXA4 - 2p13.3 [CytoView hg38]
Mapping of homologs : NCBIANXA4 [Mapview hg19]  ANXA4 [Mapview hg38]
OMIM106491   
Gene and transcription
Genbank (Entrez)AB209457 AK058017 AK293177 AK293396 AK293406
RefSeq transcript (Entrez)NM_001153 NM_001320698 NM_001320700 NM_001320702
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)ANXA4
Cluster EST : UnigeneHs.422986 [ NCBI ]
CGAP (NCI)Hs.422986
Alternative Splicing GalleryENSG00000196975
Gene ExpressionANXA4 [ NCBI-GEO ]   ANXA4 [ EBI - ARRAY_EXPRESS ]   ANXA4 [ SEEK ]   ANXA4 [ MEM ]
Gene Expression Viewer (FireBrowse)ANXA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)307
GTEX Portal (Tissue expression)ANXA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09525   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09525  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09525
Splice isoforms : SwissVarP09525
PhosPhoSitePlusP09525
Domaine pattern : Prosite (Expaxy)ANNEXIN (PS00223)   
Domains : Interpro (EBI)Annexin    Annexin_repeat    Annexin_repeat_CS    AnnexinIV   
Domain families : Pfam (Sanger)Annexin (PF00191)   
Domain families : Pfam (NCBI)pfam00191   
Domain families : Smart (EMBL)ANX (SM00335)  
Conserved Domain (NCBI)ANXA4
DMDM Disease mutations307
Blocks (Seattle)ANXA4
PDB (SRS)2ZOC   
PDB (PDBSum)2ZOC   
PDB (IMB)2ZOC   
PDB (RSDB)2ZOC   
Structural Biology KnowledgeBase2ZOC   
SCOP (Structural Classification of Proteins)2ZOC   
CATH (Classification of proteins structures)2ZOC   
SuperfamilyP09525
Human Protein AtlasENSG00000196975
Peptide AtlasP09525
HPRD00112
IPIIPI00793199   IPI00872780   
Protein Interaction databases
DIP (DOE-UCLA)P09525
IntAct (EBI)P09525
FunCoupENSG00000196975
BioGRIDANXA4
STRING (EMBL)ANXA4
ZODIACANXA4
Ontologies - Pathways
QuickGOP09525
Ontology : AmiGOphospholipase inhibitor activity  calcium ion binding  protein binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  nucleus  cytoplasm  cytoplasm  plasma membrane  regulation of transcription from RNA polymerase II promoter  signal transduction  Notch signaling pathway  cell surface  vesicle membrane  epithelial cell differentiation  nuclear membrane  negative regulation of NF-kappaB transcription factor activity  identical protein binding  negative regulation of apoptotic process  negative regulation of catalytic activity  calcium-dependent protein binding  perinuclear region of cytoplasm  NF-kappaB binding  extracellular exosome  negative regulation of interleukin-8 secretion  
Ontology : EGO-EBIphospholipase inhibitor activity  calcium ion binding  protein binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  nucleus  cytoplasm  cytoplasm  plasma membrane  regulation of transcription from RNA polymerase II promoter  signal transduction  Notch signaling pathway  cell surface  vesicle membrane  epithelial cell differentiation  nuclear membrane  negative regulation of NF-kappaB transcription factor activity  identical protein binding  negative regulation of apoptotic process  negative regulation of catalytic activity  calcium-dependent protein binding  perinuclear region of cytoplasm  NF-kappaB binding  extracellular exosome  negative regulation of interleukin-8 secretion  
NDEx NetworkANXA4
Atlas of Cancer Signalling NetworkANXA4
Wikipedia pathwaysANXA4
Orthology - Evolution
OrthoDB307
GeneTree (enSembl)ENSG00000196975
Phylogenetic Trees/Animal Genes : TreeFamANXA4
HOVERGENP09525
HOGENOMP09525
Homologs : HomoloGeneANXA4
Homology/Alignments : Family Browser (UCSC)ANXA4
Gene fusions - Rearrangements
Fusion : MitelmanABL1/ANXA4 [9q34.12/2p13.3]  [t(2;9)(p13;q34)]  
Fusion : MitelmanANXA4/TMEM67 [2p13.3/8q22.1]  [t(2;8)(p13;q22)]  
Fusion : MitelmanDENND1A/ANXA4 [9q33.3/2p13.3]  [t(2;9)(p13;q33)]  
Fusion : MitelmanGMCL1/ANXA4 [2p13.3/2p13.3]  [t(2;2)(p13;p13)]  
Fusion : MitelmanMCEE/ANXA4 [2p13.3/2p13.3]  [t(2;2)(p13;p13)]  
Fusion : MitelmanRBBP8/ANXA4 [18q11.2/2p13.3]  [t(2;18)(p13;q11)]  
Fusion: TCGAGMCL1 2p13.3 ANXA4 2p13.3 LUAD
Fusion: TCGAMCEE 2p13.3 ANXA4 2p13.3 LUAD
Fusion: TCGARBBP8 18q11.2 ANXA4 2p13.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANXA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANXA4
dbVarANXA4
ClinVarANXA4
1000_GenomesANXA4 
Exome Variant ServerANXA4
ExAC (Exome Aggregation Consortium)ANXA4 (select the gene name)
Genetic variants : HAPMAP307
Genomic Variants (DGV)ANXA4 [DGVbeta]
DECIPHER (Syndromes)2:69969106-70053609  ENSG00000196975
CONAN: Copy Number AnalysisANXA4 
Mutations
ICGC Data PortalANXA4 
TCGA Data PortalANXA4 
Broad Tumor PortalANXA4
OASIS PortalANXA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANXA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANXA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANXA4
DgiDB (Drug Gene Interaction Database)ANXA4
DoCM (Curated mutations)ANXA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANXA4 (select a term)
intoGenANXA4
Cancer3DANXA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM106491   
Orphanet
MedgenANXA4
Genetic Testing Registry ANXA4
NextProtP09525 [Medical]
TSGene307
GENETestsANXA4
Huge Navigator ANXA4 [HugePedia]
snp3D : Map Gene to Disease307
BioCentury BCIQANXA4
ClinGenANXA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD307
Chemical/Pharm GKB GenePA24832
Clinical trialANXA4
Miscellaneous
canSAR (ICR)ANXA4 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANXA4
EVEXANXA4
GoPubMedANXA4
iHOPANXA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:55:57 CET 2017

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