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ANXA5 (annexin A5)

Identity

Alias_namesENX2
ANX5
Other aliasHEL-S-7
PP4
RPRGL3
HGNC (Hugo) ANXA5
LocusID (NCBI) 308
Atlas_Id 656
Location 4q27  [Link to chromosome band 4q27]
Location_base_pair Starts at 122589152 and ends at 122618147 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANXA5 (4q27) / ANXA5 (4q27)ANXA5 (4q27) / CLASP2 (3p22.3)ANXA5 (4q27) / INO80C (18q12.2)
ANXA5 (4q27) / USP48 (1p36.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ANXA5   543
Cards
Entrez_Gene (NCBI)ANXA5  308  annexin A5
AliasesANX5; ENX2; HEL-S-7; PP4; 
RPRGL3
GeneCards (Weizmann)ANXA5
Ensembl hg19 (Hinxton)ENSG00000164111 [Gene_View]  chr4:122589152-122618147 [Contig_View]  ANXA5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164111 [Gene_View]  chr4:122589152-122618147 [Contig_View]  ANXA5 [Vega]
ICGC DataPortalENSG00000164111
TCGA cBioPortalANXA5
AceView (NCBI)ANXA5
Genatlas (Paris)ANXA5
WikiGenes308
SOURCE (Princeton)ANXA5
Genetics Home Reference (NIH)ANXA5
Genomic and cartography
GoldenPath hg19 (UCSC)ANXA5  -     chr4:122589152-122618147 -  4q27   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ANXA5  -     4q27   [Description]    (hg38-Dec_2013)
EnsemblANXA5 - 4q27 [CytoView hg19]  ANXA5 - 4q27 [CytoView hg38]
Mapping of homologs : NCBIANXA5 [Mapview hg19]  ANXA5 [Mapview hg38]
OMIM131230   614391   
Gene and transcription
Genbank (Entrez)AK297909 AK312644 AM393144 AY577779 BC001429
RefSeq transcript (Entrez)NM_001154
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_032042 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)ANXA5
Cluster EST : UnigeneHs.480653 [ NCBI ]
CGAP (NCI)Hs.480653
Alternative Splicing GalleryENSG00000164111
Gene ExpressionANXA5 [ NCBI-GEO ]   ANXA5 [ EBI - ARRAY_EXPRESS ]   ANXA5 [ SEEK ]   ANXA5 [ MEM ]
Gene Expression Viewer (FireBrowse)ANXA5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)308
GTEX Portal (Tissue expression)ANXA5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08758   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08758  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08758
Splice isoforms : SwissVarP08758
PhosPhoSitePlusP08758
Domaine pattern : Prosite (Expaxy)ANNEXIN (PS00223)   
Domains : Interpro (EBI)Annexin    Annexin_repeat    Annexin_repeat_CS    Annexins_V    AnnexinV   
Domain families : Pfam (Sanger)Annexin (PF00191)   
Domain families : Pfam (NCBI)pfam00191   
Domain families : Smart (EMBL)ANX (SM00335)  
Conserved Domain (NCBI)ANXA5
DMDM Disease mutations308
Blocks (Seattle)ANXA5
PDB (SRS)1ANW    1ANX    1AVH    1AVR    1HAK    1HVD    1HVE    1HVF    1HVG    1SAV    2XO2    2XO3   
PDB (PDBSum)1ANW    1ANX    1AVH    1AVR    1HAK    1HVD    1HVE    1HVF    1HVG    1SAV    2XO2    2XO3   
PDB (IMB)1ANW    1ANX    1AVH    1AVR    1HAK    1HVD    1HVE    1HVF    1HVG    1SAV    2XO2    2XO3   
PDB (RSDB)1ANW    1ANX    1AVH    1AVR    1HAK    1HVD    1HVE    1HVF    1HVG    1SAV    2XO2    2XO3   
Structural Biology KnowledgeBase1ANW    1ANX    1AVH    1AVR    1HAK    1HVD    1HVE    1HVF    1HVG    1SAV    2XO2    2XO3   
SCOP (Structural Classification of Proteins)1ANW    1ANX    1AVH    1AVR    1HAK    1HVD    1HVE    1HVF    1HVG    1SAV    2XO2    2XO3   
CATH (Classification of proteins structures)1ANW    1ANX    1AVH    1AVR    1HAK    1HVD    1HVE    1HVF    1HVG    1SAV    2XO2    2XO3   
SuperfamilyP08758
Human Protein AtlasENSG00000164111
Peptide AtlasP08758
HPRD00568
IPIIPI00329801   IPI00964913   IPI00967416   IPI00964365   IPI00964635   IPI00965294   
Protein Interaction databases
DIP (DOE-UCLA)P08758
IntAct (EBI)P08758
FunCoupENSG00000164111
BioGRIDANXA5
STRING (EMBL)ANXA5
ZODIACANXA5
Ontologies - Pathways
QuickGOP08758
Ontology : AmiGOpositive regulation of defense response to virus by host  phospholipase inhibitor activity  calcium-transporting ATPase activity  calcium ion binding  protein binding  phospholipid binding  calcium-dependent phospholipid binding  intracellular  nucleus  cytoplasm  endoplasmic reticulum  cytosol  focal adhesion  signal transduction  blood coagulation  synaptic vesicle  external side of plasma membrane  intercalated disc  membrane  peptide hormone binding  Z disc  negative regulation of blood coagulation  dendrite  receptor tyrosine kinase binding  sarcolemma  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of catalytic activity  perikaryon  axon terminus  protein homooligomerization  response to calcium ion  extracellular exosome  calcium ion transmembrane transport  cellular response to lead ion  endothelial microparticle  response to thyroid hormone  cellular response to gonadotropin-releasing hormone  mitophagy in response to mitochondrial depolarization  xenophagy  regulation of sperm motility  negative regulation of prolactin secretion  
Ontology : EGO-EBIpositive regulation of defense response to virus by host  phospholipase inhibitor activity  calcium-transporting ATPase activity  calcium ion binding  protein binding  phospholipid binding  calcium-dependent phospholipid binding  intracellular  nucleus  cytoplasm  endoplasmic reticulum  cytosol  focal adhesion  signal transduction  blood coagulation  synaptic vesicle  external side of plasma membrane  intercalated disc  membrane  peptide hormone binding  Z disc  negative regulation of blood coagulation  dendrite  receptor tyrosine kinase binding  sarcolemma  positive regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of catalytic activity  perikaryon  axon terminus  protein homooligomerization  response to calcium ion  extracellular exosome  calcium ion transmembrane transport  cellular response to lead ion  endothelial microparticle  response to thyroid hormone  cellular response to gonadotropin-releasing hormone  mitophagy in response to mitochondrial depolarization  xenophagy  regulation of sperm motility  negative regulation of prolactin secretion  
NDEx NetworkANXA5
Atlas of Cancer Signalling NetworkANXA5
Wikipedia pathwaysANXA5
Orthology - Evolution
OrthoDB308
GeneTree (enSembl)ENSG00000164111
Phylogenetic Trees/Animal Genes : TreeFamANXA5
HOVERGENP08758
HOGENOMP08758
Homologs : HomoloGeneANXA5
Homology/Alignments : Family Browser (UCSC)ANXA5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerANXA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ANXA5
dbVarANXA5
ClinVarANXA5
1000_GenomesANXA5 
Exome Variant ServerANXA5
ExAC (Exome Aggregation Consortium)ANXA5 (select the gene name)
Genetic variants : HAPMAP308
Genomic Variants (DGV)ANXA5 [DGVbeta]
DECIPHER (Syndromes)4:122589152-122618147  ENSG00000164111
CONAN: Copy Number AnalysisANXA5 
Mutations
ICGC Data PortalANXA5 
TCGA Data PortalANXA5 
Broad Tumor PortalANXA5
OASIS PortalANXA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICANXA5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDANXA5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ANXA5
DgiDB (Drug Gene Interaction Database)ANXA5
DoCM (Curated mutations)ANXA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ANXA5 (select a term)
intoGenANXA5
Cancer3DANXA5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM131230    614391   
Orphanet
MedgenANXA5
Genetic Testing Registry ANXA5
NextProtP08758 [Medical]
TSGene308
GENETestsANXA5
Huge Navigator ANXA5 [HugePedia]
snp3D : Map Gene to Disease308
BioCentury BCIQANXA5
ClinGenANXA5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD308
Chemical/Pharm GKB GenePA24833
Clinical trialANXA5
Miscellaneous
canSAR (ICR)ANXA5 (select the gene name)
Probes
Litterature
PubMed186 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineANXA5
EVEXANXA5
GoPubMedANXA5
iHOPANXA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:55:58 CET 2017

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