ANXA5 (annexin A5)

2003-08-01  

Identity

HGNC
ANXA5
LOCATION
4q27
LOCUSID
308
ALIAS
ANX5,ENX2,HEL-S-7,PP4,RPRGL3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 308
MIM: 131230
HGNC: 543
Ensembl: ENSG00000164111

Variants:

dbSNP: 308
ClinVar: 308
TCGA: ENSG00000164111
COSMIC: ANXA5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164111ENST00000296511P08758
ENSG00000164111ENST00000296511V9HWE0
ENSG00000164111ENST00000501272D6RBL5
ENSG00000164111ENST00000506395E9PHT9
ENSG00000164111ENST00000513728D6RCN3
ENSG00000164111ENST00000515017D6RBE9

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
153816972004Cell surface-expressed phosphatidylserine and annexin A5 open a novel portal of cell entry.37
228795872012Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells.30
152860432004Cryopreservation and thawing is associated with varying extent of activation of apoptotic machinery in subsets of ejaculated human spermatozoa.26
167852262006Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function.26
222669062012Annexin A5 stimulates autophagy and inhibits endocytosis.24
173392692007A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss.23
173392692007A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss.23
147645262004Neutrophils in Barth syndrome (BTHS) avidly bind annexin-V in the absence of apoptosis.22
170530602007Correlation between antiphospholipid antibodies that recognize domain I of beta2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5.20
189779902008Candidate genes and cerebral palsy: a population-based study.18

Citation

Dessen P

ANXA5 (annexin A5)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/656/anxa5