AOC3 (amine oxidase copper containing 3)

2007-02-01  

Identity

HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
HPAO,SSAO,VAP-1,VAP1

Other Information

Locus ID:

NCBI: 8639
MIM: 603735
HGNC: 550
Ensembl: ENSG00000131471

Variants:

dbSNP: 8639
ClinVar: 8639
TCGA: ENSG00000131471
COSMIC: AOC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131471ENST00000308423Q16853
ENSG00000131471ENST00000587330K7EIK5
ENSG00000131471ENST00000588033K7EQZ5
ENSG00000131471ENST00000591562Q16853
ENSG00000131471ENST00000592999K7EL47
ENSG00000131471ENST00000613571Q16853
ENSG00000131471ENST00000617500Q16853

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Tyrosine metabolismKEGGko00350
Phenylalanine metabolismKEGGko00360
beta-Alanine metabolismKEGGko00410
Glycine, serine and threonine metabolismKEGGhsa00260
Tyrosine metabolismKEGGhsa00350
Phenylalanine metabolismKEGGhsa00360
beta-Alanine metabolismKEGGhsa00410
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120974052002Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells.67
170069782006Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.54
255623182015Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis.40
147263752004Granulocyte transmigration through the endothelium is regulated by the oxidase activity of vascular adhesion protein-1 (VAP-1).39
218217082011Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer.36
205129912010CX(3)CR1 and vascular adhesion protein-1-dependent recruitment of CD16(+) monocytes across human liver sinusoidal endothelium.32
198616822009Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate.30
160466232005Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications.29
172567512007Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion.28
221504392012Vascular adhesion protein-1 and syndecan-1 in septic shock.23

Citation

Dessen P

AOC3 (amine oxidase copper containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45604/aoc3