AP1G1 (adaptor related protein complex 1 subunit gamma 1)

2017-11-01  

Identity

HGNC
LOCATION
16q22.2
LOCUSID
ALIAS
ADTG,CLAPG1
FUSION GENES

Other Information

Locus ID:

NCBI: 164
MIM: 603533
HGNC: 555
Ensembl: ENSG00000166747

Variants:

dbSNP: 164
ClinVar: 164
TCGA: ENSG00000166747
COSMIC: AP1G1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166747ENST00000299980O43747
ENSG00000166747ENST00000393512O43747
ENSG00000166747ENST00000393512A0A140VJE7
ENSG00000166747ENST00000450149B4DGE1
ENSG00000166747ENST00000563104H3BN71
ENSG00000166747ENST00000563259H3BR36
ENSG00000166747ENST00000564155B3KNW1
ENSG00000166747ENST00000565009H3BUN9
ENSG00000166747ENST00000565412H3BS13
ENSG00000166747ENST00000566179H3BNN2
ENSG00000166747ENST00000567583H3BV30
ENSG00000166747ENST00000568327H3BNR4
ENSG00000166747ENST00000569185H3BRM7
ENSG00000166747ENST00000569748O43747
ENSG00000166747ENST00000569975H3BN75
ENSG00000166747ENST00000570017H3BPN9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
The role of Nef in HIV-1 replication and disease pathogenesisREACTOMER-HSA-164952
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersREACTOMER-HSA-164938
Nef mediated downregulation of MHC class I complex cell surface expressionREACTOMER-HSA-164940
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
168679822006Gamma-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation.31
118721612002Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain.22
120428762002Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.21
288239582017AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis.9
294268652018The WDR11 complex facilitates the tethering of AP-1-derived vesicles.6
240062552013Rab4b controls an early endosome sorting event by interacting with the γ-subunit of the clathrin adaptor complex 1.5
279092442017CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the γ1 and γ2 subunits of the AP-1 complex in protein trafficking.5

Citation

Dessen P

AP1G1 (adaptor related protein complex 1 subunit gamma 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-11-01

Online version: http://atlasgeneticsoncology.org/gene/57249/ap1g1