AP1M1 (adaptor related protein complex 1 subunit mu 1)

2014-11-01  

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
AP47,CLAPM2,CLTNM,MU-1A,mu1A
FUSION GENES

Other Information

Locus ID:

NCBI: 8907
MIM: 603535
HGNC: 13667
Ensembl: ENSG00000072958

Variants:

dbSNP: 8907
ClinVar: 8907
TCGA: ENSG00000072958
COSMIC: AP1M1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072958ENST00000291439Q9BXS5
ENSG00000072958ENST00000291439A0A024R7K8
ENSG00000072958ENST00000429941E7ENJ6
ENSG00000072958ENST00000444449Q9BXS5
ENSG00000072958ENST00000586543K7EQX3
ENSG00000072958ENST00000589782A0A087WZX7
ENSG00000072958ENST00000589822K7ER75
ENSG00000072958ENST00000590263K7ENA7
ENSG00000072958ENST00000590756K7EJL1
ENSG00000072958ENST00000590945K7EQ90
ENSG00000072958ENST00000591775K7EPJ8

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
The role of Nef in HIV-1 replication and disease pathogenesisREACTOMER-HSA-164952
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersREACTOMER-HSA-164938
Nef mediated downregulation of MHC class I complex cell surface expressionREACTOMER-HSA-164940
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180572552008Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit.39
287438252017Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting.11
234782622013The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation.10
236781822013Adaptor protein 1 promotes cross-presentation through the same tyrosine signal in major histocompatibility complex class I as that targeted by HIV-1.10
208331402010Human kidney anion exchanger 1 interacts with adaptor-related protein complex 1 μ1A (AP-1 mu1A).9
295352042018Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release.6
223011372012A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes.4
301352092018Phosphoserine acidic cluster motifs bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes.3
254492652014Basolateral sorting of the Mg²⁺ transporter CNNM4 requires interaction with AP-1A and AP-1B.2
297939512018Varicella-Zoster Virus ORF9p Binding to Cellular Adaptor Protein Complex 1 Is Important for Viral Infectivity.2

Citation

Dessen P

AP1M1 (adaptor related protein complex 1 subunit mu 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60399/ap1m1