Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA
Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

Donate (in Euros)

Donate (in US Dollars)


AP1S1 (adaptor-related protein complex 1, sigma 1 subunit)

Identity

Other namesAP19
CLAPS1
EKV3
MEDNIK
SIGMA1A
HGNC (Hugo) AP1S1
LocusID (NCBI) 1174
Location 7q22.1
Location_base_pair Starts at 100797686 and ends at 100804557 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)AP1S1   559
Cards
Entrez_Gene (NCBI)AP1S1  1174  adaptor-related protein complex 1, sigma 1 subunit
GeneCards (Weizmann)AP1S1
Ensembl hg19 (Hinxton)ENSG00000106367 [Gene_View]  chr7:100797686-100804557 [Contig_View]  AP1S1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000106367 [Gene_View]  chr7:100797686-100804557 [Contig_View]  AP1S1 [Vega]
ICGC DataPortalENSG00000106367
cBioPortalAP1S1
AceView (NCBI)AP1S1
Genatlas (Paris)AP1S1
WikiGenes1174
SOURCE (Princeton)AP1S1
Genomic and cartography
GoldenPath hg19 (UCSC)AP1S1  -     chr7:100797686-100804557 +  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AP1S1  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblAP1S1 - 7q22.1 [CytoView hg19]  AP1S1 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIAP1S1 [Mapview hg19]  AP1S1 [Mapview hg38]
OMIM603531   609313   
Gene and transcription
Genbank (Entrez)AB015319 AK312151 BC003561 BI597121 BI598615
RefSeq transcript (Entrez)NM_001283 NM_057089
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_033082 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)AP1S1
Cluster EST : UnigeneHs.489365 [ NCBI ]
CGAP (NCI)Hs.489365
Alternative Splicing : Fast-db (Paris)GSHG0027599
Alternative Splicing GalleryENSG00000106367
Gene ExpressionAP1S1 [ NCBI-GEO ]     AP1S1 [ SEEK ]   AP1S1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61966 (Uniprot)
NextProtP61966  [Medical]
With graphics : InterProP61966
Splice isoforms : SwissVarP61966 (Swissvar)
Domaine pattern : Prosite (Expaxy)CLAT_ADAPTOR_S (PS00989)   
Domains : Interpro (EBI)AP_complex_ssu    AP_mu_sigma_su    Clathrin_sm-chain_CS    Longin-like_dom   
Related proteins : CluSTrP61966
Domain families : Pfam (Sanger)Clat_adaptor_s (PF01217)   
Domain families : Pfam (NCBI)pfam01217   
DMDM Disease mutations1174
Blocks (Seattle)P61966
PDB (SRS)4P6Z   
PDB (PDBSum)4P6Z   
PDB (IMB)4P6Z   
PDB (RSDB)4P6Z   
Human Protein AtlasENSG00000106367
Peptide AtlasP61966
HPRD04635
IPIIPI00152898   IPI00100559   IPI00927531   
Protein Interaction databases
DIP (DOE-UCLA)P61966
IntAct (EBI)P61966
FunCoupENSG00000106367
BioGRIDAP1S1
IntegromeDBAP1S1
STRING (EMBL)AP1S1
Ontologies - Pathways
QuickGOP61966
Ontology : AmiGOGolgi membrane  lysosomal membrane  cytosol  coated pit  intracellular protein transport  post-Golgi vesicle-mediated transport  receptor-mediated endocytosis  protein transporter activity  response to virus  membrane  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  AP-1 adaptor complex  cytoplasmic vesicle membrane  trans-Golgi network membrane  regulation of defense response to virus by virus  membrane organization  extracellular exosome  
Ontology : EGO-EBIGolgi membrane  lysosomal membrane  cytosol  coated pit  intracellular protein transport  post-Golgi vesicle-mediated transport  receptor-mediated endocytosis  protein transporter activity  response to virus  membrane  viral process  antigen processing and presentation of exogenous peptide antigen via MHC class II  AP-1 adaptor complex  cytoplasmic vesicle membrane  trans-Golgi network membrane  regulation of defense response to virus by virus  membrane organization  extracellular exosome  
Pathways : KEGGLysosome   
Protein Interaction DatabaseAP1S1
DoCM (Curated mutations)AP1S1
Wikipedia pathwaysAP1S1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerAP1S1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AP1S1
dbVarAP1S1
ClinVarAP1S1
1000_GenomesAP1S1 
Exome Variant ServerAP1S1
SNP (GeneSNP Utah)AP1S1
SNP : HGBaseAP1S1
Genetic variants : HAPMAPAP1S1
Genomic Variants (DGV)AP1S1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000106367 
Somatic Mutations in Cancer : COSMICAP1S1 
CONAN: Copy Number AnalysisAP1S1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:100797686-100804557
Mutations and Diseases : HGMDAP1S1
OMIM603531    609313   
MedgenAP1S1
NextProtP61966 [Medical]
GENETestsAP1S1
Disease Genetic AssociationAP1S1
Huge Navigator AP1S1 [HugePedia]  AP1S1 [HugeCancerGEM]
snp3D : Map Gene to Disease1174
DGIdb (Drug Gene Interaction db)AP1S1
General knowledge
Homologs : HomoloGeneAP1S1
Homology/Alignments : Family Browser (UCSC)AP1S1
Phylogenetic Trees/Animal Genes : TreeFamAP1S1
Chemical/Protein Interactions : CTD1174
Chemical/Pharm GKB GenePA24850
Clinical trialAP1S1
Cancer Resource (Charite)ENSG00000106367
Other databases
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
CoreMineAP1S1
GoPubMedAP1S1
iHOPAP1S1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 14:43:45 CET 2015

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.