AP2M1 (adaptor related protein complex 2 subunit mu 1)

2003-11-01  

Identity

HGNC
LOCATION
3q27.1
LOCUSID
ALIAS
AP50,CLAPM1,MRD60,mu2
FUSION GENES

Other Information

Locus ID:

NCBI: 1173
MIM: 601024
HGNC: 564
Ensembl: ENSG00000161203

Variants:

dbSNP: 1173
ClinVar: 1173
TCGA: ENSG00000161203
COSMIC: AP2M1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161203ENST00000292807Q96CW1
ENSG00000161203ENST00000382456Q96CW1
ENSG00000161203ENST00000411763E9PFW3
ENSG00000161203ENST00000427072C9JPV8
ENSG00000161203ENST00000431779C9JGT8
ENSG00000161203ENST00000432591C9JJ47
ENSG00000161203ENST00000439647Q96CW1
ENSG00000161203ENST00000442686H7C4C3
ENSG00000161203ENST00000448139C9JTK4
ENSG00000161203ENST00000455925C9JJD3
ENSG00000161203ENST00000621863A0A087WY71

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Huntington's diseaseKEGGko05016
Huntington's diseaseKEGGhsa05016
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
The role of Nef in HIV-1 replication and disease pathogenesisREACTOMER-HSA-164952
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersREACTOMER-HSA-164938
Nef mediated downregulation of CD28 cell surface expressionREACTOMER-HSA-164939
Nef Mediated CD4 Down-regulationREACTOMER-HSA-167590
Nef Mediated CD8 Down-regulationREACTOMER-HSA-182218
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Retrograde neurotrophin signallingREACTOMER-HSA-177504
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
WNT5A-dependent internalization of FZD4REACTOMER-HSA-5099900
WNT5A-dependent internalization of FZD2, FZD5 and ROR2REACTOMER-HSA-5140745
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Gap junction trafficking and regulationREACTOMER-HSA-157858
Gap junction traffickingREACTOMER-HSA-190828
Gap junction degradationREACTOMER-HSA-190873
Formation of annular gap junctionsREACTOMER-HSA-196025
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665
VLDL interactionsREACTOMER-HSA-8855121
VLDLR internalisation and degradationREACTOMER-HSA-8866427
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129529412003Clathrin-mediated endocytosis in AP-2-depleted cells.272
168803962006Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes.58
229160112012Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.53
180325172008A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2.49
159117682005Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments.48
204856802010Roles of AP-2 in clathrin-mediated endocytosis.48
250480042015Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia.41
120321422002Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery.40
172898402007Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2.39
280033332017Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2.31

Citation

Dessen P

AP2M1 (adaptor related protein complex 2 subunit mu 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/663/ap2m1