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AP4M1 (adaptor related protein complex 4 mu 1 subunit)

Identity

Alias_namesadaptor-related protein complex 4, mu 1 subunit
Alias_symbol (synonym)MU-ARP2
MU-4
SPG50
Other aliasCPSQ3
HGNC (Hugo) AP4M1
LocusID (NCBI) 9179
Atlas_Id 60410
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 100101507 and ends at 100107180 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AP4M1 (7q22.1) / AP4M1 (7q22.1)AP4M1 (7q22.1) / TAF6 (7q22.1)LYZ (12q15) / AP4M1 (7q22.1)
SLC1A2 (11p13) / AP4M1 (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AP4M1   574
Cards
Entrez_Gene (NCBI)AP4M1  9179  adaptor related protein complex 4 mu 1 subunit
AliasesCPSQ3; MU-4; MU-ARP2; SPG50
GeneCards (Weizmann)AP4M1
Ensembl hg19 (Hinxton)ENSG00000221838 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000221838 [Gene_View]  chr7:100101507-100107180 [Contig_View]  AP4M1 [Vega]
ICGC DataPortalENSG00000221838
TCGA cBioPortalAP4M1
AceView (NCBI)AP4M1
Genatlas (Paris)AP4M1
WikiGenes9179
SOURCE (Princeton)AP4M1
Genetics Home Reference (NIH)AP4M1
Genomic and cartography
GoldenPath hg38 (UCSC)AP4M1  -     chr7:100101507-100107180 +  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AP4M1  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblAP4M1 - 7q22.1 [CytoView hg19]  AP4M1 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIAP4M1 [Mapview hg19]  AP4M1 [Mapview hg38]
OMIM602296   612936   
Gene and transcription
Genbank (Entrez)AF020796 AF155158 AK055686 AK293590 AK296651
RefSeq transcript (Entrez)NM_004722
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AP4M1
Cluster EST : UnigeneHs.632317 [ NCBI ]
CGAP (NCI)Hs.632317
Alternative Splicing GalleryENSG00000221838
Gene ExpressionAP4M1 [ NCBI-GEO ]   AP4M1 [ EBI - ARRAY_EXPRESS ]   AP4M1 [ SEEK ]   AP4M1 [ MEM ]
Gene Expression Viewer (FireBrowse)AP4M1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9179
GTEX Portal (Tissue expression)AP4M1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00189   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00189  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00189
Splice isoforms : SwissVarO00189
PhosPhoSitePlusO00189
Domaine pattern : Prosite (Expaxy)CLAT_ADAPTOR_M_2 (PS00991)    MHD (PS51072)   
Domains : Interpro (EBI)AP_mu_sigma_su    Clathrin_mu    Clathrin_mu_CS    Longin-like_dom    MHD   
Domain families : Pfam (Sanger)Adap_comp_sub (PF00928)    Clat_adaptor_s (PF01217)   
Domain families : Pfam (NCBI)pfam00928    pfam01217   
Conserved Domain (NCBI)AP4M1
DMDM Disease mutations9179
Blocks (Seattle)AP4M1
PDB (SRS)3L81    4MDR   
PDB (PDBSum)3L81    4MDR   
PDB (IMB)3L81    4MDR   
PDB (RSDB)3L81    4MDR   
Structural Biology KnowledgeBase3L81    4MDR   
SCOP (Structural Classification of Proteins)3L81    4MDR   
CATH (Classification of proteins structures)3L81    4MDR   
SuperfamilyO00189
Human Protein AtlasENSG00000221838
Peptide AtlasO00189
HPRD03803
IPIIPI00103040   IPI00909400   IPI00926043   IPI00423366   IPI00926434   IPI00926596   IPI00926844   IPI00927468   IPI00927663   IPI00927908   IPI00924561   IPI00872305   
Protein Interaction databases
DIP (DOE-UCLA)O00189
IntAct (EBI)O00189
FunCoupENSG00000221838
BioGRIDAP4M1
STRING (EMBL)AP4M1
ZODIACAP4M1
Ontologies - Pathways
QuickGOO00189
Ontology : AmiGOGolgi trans cisterna  transporter activity  protein binding  trans-Golgi network  cytosol  intracellular protein transport  Golgi to endosome transport  vesicle-mediated transport  AP-type membrane coat adaptor complex  clathrin adaptor complex  endosome lumen  trans-Golgi network membrane  extracellular exosome  
Ontology : EGO-EBIGolgi trans cisterna  transporter activity  protein binding  trans-Golgi network  cytosol  intracellular protein transport  Golgi to endosome transport  vesicle-mediated transport  AP-type membrane coat adaptor complex  clathrin adaptor complex  endosome lumen  trans-Golgi network membrane  extracellular exosome  
Pathways : KEGGLysosome   
NDEx NetworkAP4M1
Atlas of Cancer Signalling NetworkAP4M1
Wikipedia pathwaysAP4M1
Orthology - Evolution
OrthoDB9179
GeneTree (enSembl)ENSG00000221838
Phylogenetic Trees/Animal Genes : TreeFamAP4M1
HOVERGENO00189
HOGENOMO00189
Homologs : HomoloGeneAP4M1
Homology/Alignments : Family Browser (UCSC)AP4M1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAP4M1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AP4M1
dbVarAP4M1
ClinVarAP4M1
1000_GenomesAP4M1 
Exome Variant ServerAP4M1
ExAC (Exome Aggregation Consortium)AP4M1 (select the gene name)
Genetic variants : HAPMAP9179
Genomic Variants (DGV)AP4M1 [DGVbeta]
DECIPHERAP4M1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAP4M1 
Mutations
ICGC Data PortalAP4M1 
TCGA Data PortalAP4M1 
Broad Tumor PortalAP4M1
OASIS PortalAP4M1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAP4M1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAP4M1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AP4M1
DgiDB (Drug Gene Interaction Database)AP4M1
DoCM (Curated mutations)AP4M1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AP4M1 (select a term)
intoGenAP4M1
Cancer3DAP4M1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602296    612936   
Orphanet20498   
MedgenAP4M1
Genetic Testing Registry AP4M1
NextProtO00189 [Medical]
TSGene9179
GENETestsAP4M1
Huge Navigator AP4M1 [HugePedia]
snp3D : Map Gene to Disease9179
BioCentury BCIQAP4M1
ClinGenAP4M1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9179
Chemical/Pharm GKB GenePA24866
Clinical trialAP4M1
Miscellaneous
canSAR (ICR)AP4M1 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAP4M1
EVEXAP4M1
GoPubMedAP4M1
iHOPAP4M1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:00:28 CEST 2017

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