Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

APBB2 (amyloid beta precursor protein binding family B member 2)

Identity

Alias_namesamyloid beta (A4) precursor protein-binding
Alias_symbol (synonym)FE65L
FE65L1
MGC35575
Other alias
HGNC (Hugo) APBB2
LocusID (NCBI) 323
Atlas_Id 55947
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 40810027 and ends at 41214618 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APBB2 (4p14) / APBB2 (4p14)APBB2 (4p14) / CCNB1 (5q13.2)APBB2 (4p14) / DMD (Xp21.2)
APBB2 (4p14) / NKIRAS1 (3p24.2)APBB2 (4p14) / NSUN7 (4p14)APBB2 (4p14) / PACS1 (11q13.1)
LIMCH1 (4p13) / APBB2 (4p14)PLA2G15 (16q22.1) / APBB2 (4p14)RBM47 (4p14) / APBB2 (4p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)APBB2   582
Cards
Entrez_Gene (NCBI)APBB2  323  amyloid beta precursor protein binding family B member 2
AliasesFE65L; FE65L1
GeneCards (Weizmann)APBB2
Ensembl hg19 (Hinxton)ENSG00000163697 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163697 [Gene_View]  chr4:40810027-41214618 [Contig_View]  APBB2 [Vega]
ICGC DataPortalENSG00000163697
TCGA cBioPortalAPBB2
AceView (NCBI)APBB2
Genatlas (Paris)APBB2
WikiGenes323
SOURCE (Princeton)APBB2
Genetics Home Reference (NIH)APBB2
Genomic and cartography
GoldenPath hg38 (UCSC)APBB2  -     chr4:40810027-41214618 -  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)APBB2  -     4p14   [Description]    (hg19-Feb_2009)
EnsemblAPBB2 - 4p14 [CytoView hg19]  APBB2 - 4p14 [CytoView hg38]
Mapping of homologs : NCBIAPBB2 [Mapview hg19]  APBB2 [Mapview hg38]
OMIM104300   602710   
Gene and transcription
Genbank (Entrez)AK024871 AK226179 AK289838 AK295974 AK299800
RefSeq transcript (Entrez)NM_001166050 NM_001166051 NM_001166052 NM_001166053 NM_001166054 NM_001330656 NM_001330658 NM_004307 NM_173075
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)APBB2
Cluster EST : UnigeneHs.479602 [ NCBI ]
CGAP (NCI)Hs.479602
Alternative Splicing GalleryENSG00000163697
Gene ExpressionAPBB2 [ NCBI-GEO ]   APBB2 [ EBI - ARRAY_EXPRESS ]   APBB2 [ SEEK ]   APBB2 [ MEM ]
Gene Expression Viewer (FireBrowse)APBB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)323
GTEX Portal (Tissue expression)APBB2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92870   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92870  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92870
Splice isoforms : SwissVarQ92870
PhosPhoSitePlusQ92870
Domaine pattern : Prosite (Expaxy)PID (PS01179)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)PH_dom-like    PTB/PI_dom    WW_dom   
Domain families : Pfam (Sanger)PID (PF00640)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00640    pfam00397   
Domain families : Smart (EMBL)PTB (SM00462)  WW (SM00456)  
Conserved Domain (NCBI)APBB2
DMDM Disease mutations323
Blocks (Seattle)APBB2
SuperfamilyQ92870
Human Protein AtlasENSG00000163697
Peptide AtlasQ92870
HPRD04088
IPIIPI00470455   IPI00470456   IPI00968001   IPI00947448   IPI00946577   IPI00964562   IPI00973509   IPI00964656   IPI00965350   IPI00964033   IPI00967759   IPI00965110   IPI00964939   IPI00967642   IPI00966944   IPI00965582   IPI00964841   
Protein Interaction databases
DIP (DOE-UCLA)Q92870
IntAct (EBI)Q92870
FunCoupENSG00000163697
BioGRIDAPBB2
STRING (EMBL)APBB2
ZODIACAPBB2
Ontologies - Pathways
QuickGOQ92870
Ontology : AmiGObeta-amyloid binding  beta-amyloid binding  neuron migration  protein binding  nucleus  nucleus  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  cell cycle arrest  axon guidance  transcription factor binding  transcription factor binding  membrane  lamellipodium  extracellular matrix organization  negative regulation of cell growth  growth cone  intracellular signal transduction  positive regulation of apoptotic process  negative regulation of apoptotic process  synapse  
Ontology : EGO-EBIbeta-amyloid binding  beta-amyloid binding  neuron migration  protein binding  nucleus  nucleus  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  cell cycle arrest  axon guidance  transcription factor binding  transcription factor binding  membrane  lamellipodium  extracellular matrix organization  negative regulation of cell growth  growth cone  intracellular signal transduction  positive regulation of apoptotic process  negative regulation of apoptotic process  synapse  
NDEx NetworkAPBB2
Atlas of Cancer Signalling NetworkAPBB2
Wikipedia pathwaysAPBB2
Orthology - Evolution
OrthoDB323
GeneTree (enSembl)ENSG00000163697
Phylogenetic Trees/Animal Genes : TreeFamAPBB2
HOVERGENQ92870
HOGENOMQ92870
Homologs : HomoloGeneAPBB2
Homology/Alignments : Family Browser (UCSC)APBB2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPBB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APBB2
dbVarAPBB2
ClinVarAPBB2
1000_GenomesAPBB2 
Exome Variant ServerAPBB2
ExAC (Exome Aggregation Consortium)APBB2 (select the gene name)
Genetic variants : HAPMAP323
Genomic Variants (DGV)APBB2 [DGVbeta]
DECIPHERAPBB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAPBB2 
Mutations
ICGC Data PortalAPBB2 
TCGA Data PortalAPBB2 
Broad Tumor PortalAPBB2
OASIS PortalAPBB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPBB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAPBB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APBB2
DgiDB (Drug Gene Interaction Database)APBB2
DoCM (Curated mutations)APBB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APBB2 (select a term)
intoGenAPBB2
Cancer3DAPBB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104300    602710   
Orphanet
MedgenAPBB2
Genetic Testing Registry APBB2
NextProtQ92870 [Medical]
TSGene323
GENETestsAPBB2
Target ValidationAPBB2
Huge Navigator APBB2 [HugePedia]
snp3D : Map Gene to Disease323
BioCentury BCIQAPBB2
ClinGenAPBB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD323
Chemical/Pharm GKB GenePA24874
Clinical trialAPBB2
Miscellaneous
canSAR (ICR)APBB2 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPBB2
EVEXAPBB2
GoPubMedAPBB2
iHOPAPBB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:46:56 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.