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APBB2 (amyloid beta precursor protein binding family B member 2)

Identity

Alias (NCBI)FE65L
FE65L1
HGNC (Hugo) APBB2
HGNC Alias symbFE65L
FE65L1
MGC35575
HGNC Alias nameFe65-like
HGNC Previous nameamyloid beta (A4) precursor protein-binding, family B, member 2
LocusID (NCBI) 323
Atlas_Id 55947
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 40810027 and ends at 41214542 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APBB2 (4p14)::APBB2 (4p14)APBB2 (4p14)::CCNB1 (5q13.2)APBB2 (4p14)::DMD (Xp21.2)
APBB2 (4p14)::NKIRAS1 (3p24.2)APBB2 (4p14)::NSUN7 (4p14)APBB2 (4p14)::PACS1 (11q13.1)
LIMCH1 (4p13)::APBB2 (4p14)PLA2G15 (16q22.1)::APBB2 (4p14)RBM47 (4p14)::APBB2 (4p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)APBB2   582
Cards
Entrez_Gene (NCBI)APBB2    amyloid beta precursor protein binding family B member 2
AliasesFE65L; FE65L1
GeneCards (Weizmann)APBB2
Ensembl hg19 (Hinxton)ENSG00000163697 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163697 [Gene_View]  ENSG00000163697 [Sequence]  chr4:40810027-41214542 [Contig_View]  APBB2 [Vega]
ICGC DataPortalENSG00000163697
TCGA cBioPortalAPBB2
AceView (NCBI)APBB2
Genatlas (Paris)APBB2
SOURCE (Princeton)APBB2
Genetics Home Reference (NIH)APBB2
Genomic and cartography
GoldenPath hg38 (UCSC)APBB2  -     chr4:40810027-41214542 -  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)APBB2  -     4p14   [Description]    (hg19-Feb_2009)
GoldenPathAPBB2 - 4p14 [CytoView hg19]  APBB2 - 4p14 [CytoView hg38]
ImmunoBaseENSG00000163697
Genome Data Viewer NCBIAPBB2 [Mapview hg19]  
OMIM602710   
Gene and transcription
Genbank (Entrez)AK024871 AK226179 AK289838 AK295974 AK299800
RefSeq transcript (Entrez)NM_001166050 NM_001166051 NM_001166052 NM_001166053 NM_001166054 NM_001330656 NM_001330658 NM_004307 NM_173075
Consensus coding sequences : CCDS (NCBI)APBB2
Gene ExpressionAPBB2 [ NCBI-GEO ]   APBB2 [ EBI - ARRAY_EXPRESS ]   APBB2 [ SEEK ]   APBB2 [ MEM ]
Gene Expression Viewer (FireBrowse)APBB2 [ Firebrowse - Broad ]
GenevisibleExpression of APBB2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)323
GTEX Portal (Tissue expression)APBB2
Human Protein AtlasENSG00000163697-APBB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92870   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92870  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92870
PhosPhoSitePlusQ92870
Domaine pattern : Prosite (Expaxy)PID (PS01179)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)Fe65    PH-like_dom_sf    PTB/PI_dom    WW_dom    WW_dom_sf   
Domain families : Pfam (Sanger)PID (PF00640)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00640    pfam00397   
Domain families : Smart (EMBL)PTB (SM00462)  WW (SM00456)  
Conserved Domain (NCBI)APBB2
SuperfamilyQ92870
AlphaFold pdb e-kbQ92870   
Human Protein Atlas [tissue]ENSG00000163697-APBB2 [tissue]
HPRD04088
Protein Interaction databases
DIP (DOE-UCLA)Q92870
IntAct (EBI)Q92870
BioGRIDAPBB2
STRING (EMBL)APBB2
ZODIACAPBB2
Ontologies - Pathways
QuickGOQ92870
Ontology : AmiGOamyloid-beta binding  protein binding  nucleus  nucleus  cytoplasm  regulation of transcription, DNA-templated  transcription factor binding  transcription factor binding  membrane  lamellipodium  negative regulation of cell growth  growth cone  intracellular signal transduction  synapse  synapse organization  regulation of cell cycle  
Ontology : EGO-EBIamyloid-beta binding  protein binding  nucleus  nucleus  cytoplasm  regulation of transcription, DNA-templated  transcription factor binding  transcription factor binding  membrane  lamellipodium  negative regulation of cell growth  growth cone  intracellular signal transduction  synapse  synapse organization  regulation of cell cycle  
NDEx NetworkAPBB2
Atlas of Cancer Signalling NetworkAPBB2
Wikipedia pathwaysAPBB2
Orthology - Evolution
OrthoDB323
GeneTree (enSembl)ENSG00000163697
Phylogenetic Trees/Animal Genes : TreeFamAPBB2
Homologs : HomoloGeneAPBB2
Homology/Alignments : Family Browser (UCSC)APBB2
Gene fusions - Rearrangements
Fusion : QuiverAPBB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPBB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APBB2
dbVarAPBB2
ClinVarAPBB2
MonarchAPBB2
1000_GenomesAPBB2 
Exome Variant ServerAPBB2
GNOMAD BrowserENSG00000163697
Varsome BrowserAPBB2
ACMGAPBB2 variants
VarityQ92870
Genomic Variants (DGV)APBB2 [DGVbeta]
DECIPHERAPBB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAPBB2 
Mutations
ICGC Data PortalAPBB2 
TCGA Data PortalAPBB2 
Broad Tumor PortalAPBB2
OASIS PortalAPBB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPBB2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAPBB2
Mutations and Diseases : HGMDAPBB2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaAPBB2
DgiDB (Drug Gene Interaction Database)APBB2
DoCM (Curated mutations)APBB2
CIViC (Clinical Interpretations of Variants in Cancer)APBB2
Cancer3DAPBB2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602710   
Orphanet
DisGeNETAPBB2
MedgenAPBB2
Genetic Testing Registry APBB2
NextProtQ92870 [Medical]
GENETestsAPBB2
Target ValidationAPBB2
Huge Navigator APBB2 [HugePedia]
ClinGenAPBB2
Clinical trials, drugs, therapy
MyCancerGenomeAPBB2
Protein Interactions : CTDAPBB2
Pharm GKB GenePA24874
PharosQ92870
Clinical trialAPBB2
Miscellaneous
canSAR (ICR)APBB2
HarmonizomeAPBB2
ARCHS4APBB2
DataMed IndexAPBB2
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXAPBB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jan 17 15:14:48 CET 2022

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