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APC2 (adenomatosis polyposis coli 2)

Identity

Alias_namesadenomatosis polyposis coli 2
Alias_symbol (synonym)APCL
Other alias
HGNC (Hugo) APC2
LocusID (NCBI) 10297
Atlas_Id 666
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 1450148 and ends at 1473243 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
APC2 (19p13.3) / GIGYF2 (2q37.1)C19orf25 (19p13.3) / APC2 (19p13.3)TCF3 (19p13.3) / APC2 (19p13.3)
APC2 19p13.3 / GIGYF2 2q37.1TCF3 19p13.3 / APC2 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)APC2   24036
Cards
Entrez_Gene (NCBI)APC2  10297  adenomatosis polyposis coli 2
AliasesAPCL
GeneCards (Weizmann)APC2
Ensembl hg19 (Hinxton)ENSG00000115266 [Gene_View]  chr19:1450148-1473243 [Contig_View]  APC2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000115266 [Gene_View]  chr19:1450148-1473243 [Contig_View]  APC2 [Vega]
ICGC DataPortalENSG00000115266
TCGA cBioPortalAPC2
AceView (NCBI)APC2
Genatlas (Paris)APC2
WikiGenes10297
SOURCE (Princeton)APC2
Genetics Home Reference (NIH)APC2
Genomic and cartography
GoldenPath hg19 (UCSC)APC2  -     chr19:1450148-1473243 +  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)APC2  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblAPC2 - 19p13.3 [CytoView hg19]  APC2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIAPC2 [Mapview hg19]  APC2 [Mapview hg38]
OMIM612034   
Gene and transcription
Genbank (Entrez)AB012162 AF110334 AF128222 AJ012652 AL078616
RefSeq transcript (Entrez)NM_005883
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)APC2
Cluster EST : UnigeneHs.446376 [ NCBI ]
CGAP (NCI)Hs.446376
Alternative Splicing GalleryENSG00000115266
Gene ExpressionAPC2 [ NCBI-GEO ]   APC2 [ EBI - ARRAY_EXPRESS ]   APC2 [ SEEK ]   APC2 [ MEM ]
Gene Expression Viewer (FireBrowse)APC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10297
GTEX Portal (Tissue expression)APC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95996   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95996  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95996
Splice isoforms : SwissVarO95996
PhosPhoSitePlusO95996
Domains : Interpro (EBI)APC2    APC_basic_dom    APC_dom    Apc_fam    APC_N    APC_rpt    ARM-like    ARM-type_fold    Armadillo    SAMP   
Domain families : Pfam (Sanger)APC_basic (PF05956)    APC_crr (PF05923)    APC_N_CC (PF16689)    Arm (PF00514)    SAMP (PF05924)   
Domain families : Pfam (NCBI)pfam05956    pfam05923    pfam16689    pfam00514    pfam05924   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)APC2
DMDM Disease mutations10297
Blocks (Seattle)APC2
SuperfamilyO95996
Human Protein AtlasENSG00000115266
Peptide AtlasO95996
HPRD09802
IPIIPI00025190   IPI00017891   IPI00880059   IPI01018138   
Protein Interaction databases
DIP (DOE-UCLA)O95996
IntAct (EBI)O95996
FunCoupENSG00000115266
BioGRIDAPC2
STRING (EMBL)APC2
ZODIACAPC2
Ontologies - Pathways
QuickGOO95996
Ontology : AmiGOcell fate specification  protein binding  cytoplasm  Golgi apparatus  cytoplasmic microtubule  actin filament  negative regulation of microtubule depolymerization  pattern specification process  beta-catenin binding  microtubule binding  cell proliferation  microtubule cytoskeleton  Wnt signaling pathway  catenin complex  cell migration  beta-catenin destruction complex  lamellipodium membrane  negative regulation of catenin import into nucleus  gamma-catenin binding  regulation of cell differentiation  positive regulation of protein catabolic process  perinuclear region of cytoplasm  negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIcell fate specification  protein binding  cytoplasm  Golgi apparatus  cytoplasmic microtubule  actin filament  negative regulation of microtubule depolymerization  pattern specification process  beta-catenin binding  microtubule binding  cell proliferation  microtubule cytoskeleton  Wnt signaling pathway  catenin complex  cell migration  beta-catenin destruction complex  lamellipodium membrane  negative regulation of catenin import into nucleus  gamma-catenin binding  regulation of cell differentiation  positive regulation of protein catabolic process  perinuclear region of cytoplasm  negative regulation of canonical Wnt signaling pathway  
Pathways : KEGGWnt signaling pathway    Hippo signaling pathway    Regulation of actin cytoskeleton    HTLV-I infection    Pathways in cancer    MicroRNAs in cancer    Colorectal cancer    Endometrial cancer    Basal cell carcinoma   
NDEx NetworkAPC2
Atlas of Cancer Signalling NetworkAPC2
Wikipedia pathwaysAPC2
Orthology - Evolution
OrthoDB10297
GeneTree (enSembl)ENSG00000115266
Phylogenetic Trees/Animal Genes : TreeFamAPC2
HOVERGENO95996
HOGENOMO95996
Homologs : HomoloGeneAPC2
Homology/Alignments : Family Browser (UCSC)APC2
Gene fusions - Rearrangements
Fusion : MitelmanAPC2/GIGYF2 [19p13.3/2q37.1]  
Fusion : MitelmanC19orf25/APC2 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanTCF3/APC2 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGAAPC2 19p13.3 GIGYF2 2q37.1 LGG
Fusion: TCGATCF3 19p13.3 APC2 19p13.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APC2
dbVarAPC2
ClinVarAPC2
1000_GenomesAPC2 
Exome Variant ServerAPC2
ExAC (Exome Aggregation Consortium)APC2 (select the gene name)
Genetic variants : HAPMAP10297
Genomic Variants (DGV)APC2 [DGVbeta]
DECIPHER (Syndromes)19:1450148-1473243  ENSG00000115266
CONAN: Copy Number AnalysisAPC2 
Mutations
ICGC Data PortalAPC2 
TCGA Data PortalAPC2 
Broad Tumor PortalAPC2
OASIS PortalAPC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAPC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APC2
DgiDB (Drug Gene Interaction Database)APC2
DoCM (Curated mutations)APC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APC2 (select a term)
intoGenAPC2
Cancer3DAPC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612034   
Orphanet588   
MedgenAPC2
Genetic Testing Registry APC2
NextProtO95996 [Medical]
TSGene10297
GENETestsAPC2
Huge Navigator APC2 [HugePedia]
snp3D : Map Gene to Disease10297
BioCentury BCIQAPC2
ClinGenAPC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10297
Chemical/Pharm GKB GenePA134906843
Clinical trialAPC2
Miscellaneous
canSAR (ICR)APC2 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPC2
EVEXAPC2
GoPubMedAPC2
iHOPAPC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:52:36 CEST 2017

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