APC2 (APC regulator of WNT signaling pathway 2)

2003-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
APCL
FUSION GENES

Other Information

Locus ID:

NCBI: 10297
MIM: 612034
HGNC: 24036
Ensembl: ENSG00000115266

Variants:

dbSNP: 10297
ClinVar: 10297
TCGA: ENSG00000115266
COSMIC: APC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115266ENST00000233607O95996
ENSG00000115266ENST00000238483B5MDS5
ENSG00000115266ENST00000535453O95996
ENSG00000115266ENST00000587149K7ERC5
ENSG00000115266ENST00000587869K7EN62
ENSG00000115266ENST00000590469A0A0C4DGQ0
ENSG00000115266ENST00000590877K7ELQ3

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Regulation of actin cytoskeletonKEGGko04810
Colorectal cancerKEGGko05210
Endometrial cancerKEGGko05213
Basal cell carcinomaKEGGko05217
Wnt signaling pathwayKEGGhsa04310
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Endometrial cancerKEGGhsa05213
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
259602172015MiR-939 promotes the proliferation of human ovarian cancer cells by repressing APC2 expression.20
225130882012Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization.17
238408862013Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.16
311099672019Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
270687432016The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2.10
276949022017Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.9
295174842018Sumoylation promotes optimal APC/C Activation and Timely Anaphase.9

Citation

Dessen P

APC2 (APC regulator of WNT signaling pathway 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/666/apc2