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APC2 (APC2, WNT signaling pathway regulator)

Identity

Alias_namesadenomatosis polyposis coli 2
Alias_symbol (synonym)APCL
Other aliasSOTOS3
HGNC (Hugo) APC2
LocusID (NCBI) 10297
Atlas_Id 666
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 1450149 and ends at 1473244 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APC2 (19p13.3) / GIGYF2 (2q37.1)C19orf25 (19p13.3) / APC2 (19p13.3)TCF3 (19p13.3) / APC2 (19p13.3)
APC2 19p13.3 / GIGYF2 2q37.1TCF3 19p13.3 / APC2 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)APC2   24036
Cards
Entrez_Gene (NCBI)APC2  10297  APC2, WNT signaling pathway regulator
AliasesAPCL; SOTOS3
GeneCards (Weizmann)APC2
Ensembl hg19 (Hinxton)ENSG00000115266 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115266 [Gene_View]  chr19:1450149-1473244 [Contig_View]  APC2 [Vega]
ICGC DataPortalENSG00000115266
TCGA cBioPortalAPC2
AceView (NCBI)APC2
Genatlas (Paris)APC2
WikiGenes10297
SOURCE (Princeton)APC2
Genetics Home Reference (NIH)APC2
Genomic and cartography
GoldenPath hg38 (UCSC)APC2  -     chr19:1450149-1473244 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)APC2  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblAPC2 - 19p13.3 [CytoView hg19]  APC2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIAPC2 [Mapview hg19]  APC2 [Mapview hg38]
OMIM612034   617169   
Gene and transcription
Genbank (Entrez)AB012162 AF110334 AF128222 AJ012652 AL078616
RefSeq transcript (Entrez)NM_005883
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)APC2
Cluster EST : UnigeneHs.446376 [ NCBI ]
CGAP (NCI)Hs.446376
Alternative Splicing GalleryENSG00000115266
Gene ExpressionAPC2 [ NCBI-GEO ]   APC2 [ EBI - ARRAY_EXPRESS ]   APC2 [ SEEK ]   APC2 [ MEM ]
Gene Expression Viewer (FireBrowse)APC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10297
GTEX Portal (Tissue expression)APC2
Human Protein AtlasENSG00000115266-APC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95996   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95996  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95996
Splice isoforms : SwissVarO95996
PhosPhoSitePlusO95996
Domains : Interpro (EBI)APC2    APC_basic_dom    APC_dom    Apc_fam    APC_N    APC_rpt    ARM-like    ARM-type_fold    Armadillo    SAMP   
Domain families : Pfam (Sanger)APC_basic (PF05956)    APC_N_CC (PF16689)    APC_r (PF05923)    Arm (PF00514)    SAMP (PF05924)   
Domain families : Pfam (NCBI)pfam05956    pfam16689    pfam05923    pfam00514    pfam05924   
Domain families : Smart (EMBL)ARM (SM00185)  
Conserved Domain (NCBI)APC2
DMDM Disease mutations10297
Blocks (Seattle)APC2
SuperfamilyO95996
Human Protein Atlas [tissue]ENSG00000115266-APC2 [tissue]
Peptide AtlasO95996
HPRD09802
IPIIPI00025190   IPI00017891   IPI00880059   IPI01018138   
Protein Interaction databases
DIP (DOE-UCLA)O95996
IntAct (EBI)O95996
FunCoupENSG00000115266
BioGRIDAPC2
STRING (EMBL)APC2
ZODIACAPC2
Ontologies - Pathways
QuickGOO95996
Ontology : AmiGOmicrotubule cytoskeleton organization  protein binding  cytoplasm  Golgi apparatus  cytoplasmic microtubule  actin filament  beta-catenin binding  microtubule binding  microtubule cytoskeleton  Wnt signaling pathway  catenin complex  lamellipodium membrane  filamentous actin  negative regulation of catenin import into nucleus  perinuclear region of cytoplasm  negative regulation of canonical Wnt signaling pathway  activation of GTPase activity  
Ontology : EGO-EBImicrotubule cytoskeleton organization  protein binding  cytoplasm  Golgi apparatus  cytoplasmic microtubule  actin filament  beta-catenin binding  microtubule binding  microtubule cytoskeleton  Wnt signaling pathway  catenin complex  lamellipodium membrane  filamentous actin  negative regulation of catenin import into nucleus  perinuclear region of cytoplasm  negative regulation of canonical Wnt signaling pathway  activation of GTPase activity  
Pathways : KEGG   
NDEx NetworkAPC2
Atlas of Cancer Signalling NetworkAPC2
Wikipedia pathwaysAPC2
Orthology - Evolution
OrthoDB10297
GeneTree (enSembl)ENSG00000115266
Phylogenetic Trees/Animal Genes : TreeFamAPC2
HOVERGENO95996
HOGENOMO95996
Homologs : HomoloGeneAPC2
Homology/Alignments : Family Browser (UCSC)APC2
Gene fusions - Rearrangements
Fusion : MitelmanAPC2/GIGYF2 [19p13.3/2q37.1]  
Fusion : MitelmanC19orf25/APC2 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanTCF3/APC2 [19p13.3/19p13.3]  [t(19;19)(p13;p13)]  
Fusion: TCGA_MDACCAPC2 19p13.3 GIGYF2 2q37.1 LGG
Fusion: TCGA_MDACCTCF3 19p13.3 APC2 19p13.3 PRAD
Tumor Fusion PortalAPC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APC2
dbVarAPC2
ClinVarAPC2
1000_GenomesAPC2 
Exome Variant ServerAPC2
ExAC (Exome Aggregation Consortium)ENSG00000115266
GNOMAD BrowserENSG00000115266
Genetic variants : HAPMAP10297
Genomic Variants (DGV)APC2 [DGVbeta]
DECIPHERAPC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAPC2 
Mutations
ICGC Data PortalAPC2 
TCGA Data PortalAPC2 
Broad Tumor PortalAPC2
OASIS PortalAPC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAPC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APC2
DgiDB (Drug Gene Interaction Database)APC2
DoCM (Curated mutations)APC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APC2 (select a term)
intoGenAPC2
Cancer3DAPC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612034    617169   
Orphanet588   
DisGeNETAPC2
MedgenAPC2
Genetic Testing Registry APC2
NextProtO95996 [Medical]
TSGene10297
GENETestsAPC2
Target ValidationAPC2
Huge Navigator APC2 [HugePedia]
snp3D : Map Gene to Disease10297
BioCentury BCIQ//www.biocentury.com/targets/APC2 TARGET=BioCentury>APC2
ClinGenAPC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10297
Chemical/Pharm GKB GenePA134906843
Clinical trialAPC2
Miscellaneous
canSAR (ICR)APC2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPC2
EVEXAPC2
GoPubMedAPC2
iHOPAPC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:03:15 CET 2017

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