| Nomenclature | | HGNC (Hugo) | APEX1 587 |
| Entrez_Gene (NCBI) | APEX1 328 APEX nuclease (multifunctional DNA repair enzyme) 1 |
| Cards | | GeneCards (Weizmann) | APEX1 |
| Ensembl (Hinxton) | ENSG00000100823 [Gene_View] chr14:20923290-20925931 [Contig_View] APEX1 [Vega] |
| AceView (NCBI) | APEX1 |
| Genatlas (Paris) | APEX1 |
| SOURCE (Stanford) | NM_001244249 NM_001641 NM_080648 NM_080649 |
| Genomic and cartography | | GoldenPath (UCSC) | APEX1 - 14q11.2 chr14:20923290-20925931 + 14q11.2 [Description] (hg19-Feb_2009) |
| Ensembl | APEX1 - 14q11.2 [CytoView] |
| Mapping of homologs : NCBI | APEX1 [Mapview] |
| OMIM | 107748 |
| Gene and transcription |
| Genbank (Entrez) | AI554786 AK098588 AK291100 BC002338 BC004979 |
| RefSeq transcript (SRS) | NM_001244249 NM_001641 NM_080648 NM_080649 |
| RefSeq transcript (Entrez) | NM_001244249 NM_001641 NM_080648 NM_080649 |
| RefSeq genomic (SRS) | AC_000146 NC_000014 NC_018925 NG_008718 NT_026437 NW_001838110 NW_004078079 |
| RefSeq genomic (Entrez) | AC_000146 NC_000014 NC_018925 NG_008718 NT_026437 NW_001838110 NW_004078079 |
| Consensus coding sequences : CCDS (NCBI) | APEX1 |
| Cluster EST : Unigene | Hs.73722 [ SRS ] Hs.73722 [ NCBI ] |
| CGAP (NCI) | Hs.73722 |
| Alternative Splicing : Fast-db (Paris) | GSHG0008688 |
| Alternative Splicing Gallery | ENSG00000100823 |
| Gene Expression | APEX1 [ NCBI-GEO ] APEX1 [ EBI - ARRAY_EXPRESS ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P27695 (SRS) P27695 (Uniprot) |
| NextProt | P27695 |
| With graphics : InterPro | P27695 |
| Splice isoforms : SwissVar | P27695(Swissvar) |
| Domaine pattern : Prosite (SRS) | AP_NUCLEASE_F1_1 (PS00726) AP_NUCLEASE_F1_2 (PS00727) AP_NUCLEASE_F1_3 (PS00728) AP_NUCLEASE_F1_4 (PS51435) |
| Domaine pattern : Prosite (Expaxy) | AP_NUCLEASE_F1_1 (PS00726) AP_NUCLEASE_F1_2 (PS00727) AP_NUCLEASE_F1_3 (PS00728) AP_NUCLEASE_F1_4 (PS51435) |
| Domains : Interpro (SRS) | AP_endonuclease_F1_BS AP_endonuclease_F1_CS Endo/exonuclease/phosphatase ExoDNase_III |
| Domains : Interpro (EBI) | AP_endonuclease_F1_BS AP_endonuclease_F1_CS Endo/exonuclease/phosphatase ExoDNase_III |
| Related proteins : CluSTr | P27695 |
| Domain families : Pfam (SRS) | Exo_endo_phos (PF03372) |
| Domain families : Pfam (Sanger) | Exo_endo_phos (PF03372) |
| Domain families : Pfam (NCBI) | pfam03372 |
| DMDM | 328 |
| Blocks (Seattle) | P27695 |
| PDB (SRS) | 1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U |
| PDB (PDBSum) | 1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U |
| PDB (IMB) | 1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U |
| PDB (RSDB) | 1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U |
| Human Protein Atlas | ENSG00000100823 |
| HPRD | 00136 |
| IPI | IPI00215911 IPI01025699 IPI01025878 IPI01025537 IPI01025654 IPI01025255 IPI01025023 IPI01024798 IPI01026385 IPI01026512 IPI00792538 IPI00978725 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P27695 |
| IntAct (EBI) | P27695 |
| FunCoup | ENSG00000100823 |
| REACTOME | APEX1 |
| Protein Interaction Database | 328 |
| BioGRID | APEX1 |
| InParanoid | P27695 |
| Interologous Interaction database | P27695 |
| IntegromeDB | APEX1 |
| Polymorphism : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | APEX1 |
| SNP (GeneSNP Utah) | APEX1 |
| SNP : HGBase | APEX1 |
| Genetic variants : HAPMAP | APEX1 |
| Somatic Mutations in Cancer : COSMIC | APEX1 |
| CONAN: Copy Number Analysis | APEX1 |
| Mutations and Diseases : HGMD | APEX1 |
| OMIM | 107748 |
| GENETests | 107748 |
| Disease Genetic Association | APEX1 |
| Huge Navigator |
APEX1 [HugePedia] APEX1 [HugeCancerGEM] |
| Genomic Variants | APEX1 APEX1 [DGVbeta] |
| snp3D : Map Gene to Disease | 328 |
| General knowledge |
|---|
| Homologs : HomoloGene | APEX1 |
| Homology/Alignments : Family Browser (UCSC) | APEX1 |
| Phylogenetic Trees/Animal Genes : TreeFam | APEX1 |
| Catalytic activity : Enzyme | 3.1.-.- [ Enzyme-Expasy ] 3.1.-.- [ Enzyme-SRS ] 3.1.-.- [ IntEnz-EBI ] 3.1.-.- [ BRENDA ] 3.1.-.- [ KEGG ] |
| Chemical/Protein Interactions : CTD | 328 |
| Chemical/Pharm GKB Gene | PA201059 |
| Clinical trial | APEX1 |
| Cancer Resource (Charite) | ENSG00000100823 |
| Ontology : AmiGO | DNA binding damaged DNA binding transcription coactivator activity transcription corepressor activity RNA binding DNA-(apurinic or apyrimidinic site) lyase activity DNA-(apurinic or apyrimidinic site) lyase activity endonuclease activity endodeoxyribonuclease activity ribonuclease H activity phosphodiesterase I activity uracil DNA N-glycosylase activity protein binding nucleus nucleoplasm nucleoplasm nucleolus cytoplasm mitochondrion endoplasmic reticulum centrosome ribosome DNA repair DNA repair base-excision repair DNA recombination transcription, DNA-dependent regulation of transcription, DNA-dependent phosphoric diester hydrolase activity 3'-5' exonuclease activity 3'-5' exonuclease activity oxidoreductase activity nuclear speck site-specific endodeoxyribonuclease activity, specific for altered base chromatin DNA binding regulation of mRNA stability cell redox homeostasis positive regulation of DNA repair metal ion binding perinuclear region of cytoplasm oxidation-reduction process DNA demethylation |
| Ontology : EGO-EBI | DNA binding damaged DNA binding transcription coactivator activity transcription corepressor activity RNA binding DNA-(apurinic or apyrimidinic site) lyase activity DNA-(apurinic or apyrimidinic site) lyase activity endonuclease activity endodeoxyribonuclease activity ribonuclease H activity phosphodiesterase I activity uracil DNA N-glycosylase activity protein binding nucleus nucleoplasm nucleoplasm nucleolus cytoplasm mitochondrion endoplasmic reticulum centrosome ribosome DNA repair DNA repair base-excision repair DNA recombination transcription, DNA-dependent regulation of transcription, DNA-dependent phosphoric diester hydrolase activity 3'-5' exonuclease activity 3'-5' exonuclease activity oxidoreductase activity nuclear speck site-specific endodeoxyribonuclease activity, specific for altered base chromatin DNA binding regulation of mRNA stability cell redox homeostasis positive regulation of DNA repair metal ion binding perinuclear region of cytoplasm oxidation-reduction process DNA demethylation |
| Pathways : BIOCARTA | Granzyme A mediated Apoptosis Pathway [Genes] |
| Other databases |
| Probes |
|---|
| Litterature | | PubMed | 361 Pubmed reference(s) in Entrez |
| PubGene | APEX1 |
| iHOP | APEX1 |
