Identity
HGNC
LOCATION
15q22.2
LOCUSID
ALIAS
APH-1B,PRO1328,PSFL,TAAV688
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 83464
MIM: 607630
HGNC: 24080
Ensembl: ENSG00000138613
Variants:
dbSNP: 83464
ClinVar: 83464
TCGA: ENSG00000138613
COSMIC: APH1B
RNA/Proteins
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34732252 | 2021 | Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer's disease. | 11 |
| 34732252 | 2021 | Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-β deposition in Alzheimer's disease. | 11 |
| 31995180 | 2020 | Negative evidence for a role of APH1B T27I variant in Alzheimer's disease. | 3 |
| 31995180 | 2020 | Negative evidence for a role of APH1B T27I variant in Alzheimer's disease. | 3 |
| 27608597 | 2016 | Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase. | 8 |
| 27608597 | 2016 | Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase. | 8 |
| 23665252 | 2013 | Imatinib methanesulfonate reduces hippocampal amyloid-β and restores cognitive function following repeated endotoxin exposure. | 9 |
| 23665252 | 2013 | Imatinib methanesulfonate reduces hippocampal amyloid-β and restores cognitive function following repeated endotoxin exposure. | 9 |
| 19774691 | 2009 | Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations. | 1 |
| 19774691 | 2009 | Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations. | 1 |
| 19774691 | 2009 | Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations. | 1 |
| 19774691 | 2009 | Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations. | 1 |
| 17466415 | 2008 | Interaction between the APOE epsilon4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease. | 1 |
| 17466415 | 2008 | Interaction between the APOE epsilon4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease. | 1 |
| 18987747 | 2008 | Male-specific association between a gamma-secretase polymorphism and premature coronary atherosclerosis. | 3 |
Citation
Dessen P
APH1B (aph-1 homolog B, gamma-secretase subunit)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47465/aph1b
