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APLP1 (amyloid beta precursor like protein 1)

Identity

Alias_namesamyloid beta (A4) precursor-like protein 1
Alias_symbol (synonym)APLP
Other alias
HGNC (Hugo) APLP1
LocusID (NCBI) 333
Atlas_Id 50382
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35868445 and ends at 35879797 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABHD14B (3p21.2) / APLP1 (19q13.12)APLP1 (19q13.12) / B2M (15q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)APLP1   597
Cards
Entrez_Gene (NCBI)APLP1  333  amyloid beta precursor like protein 1
AliasesAPLP
GeneCards (Weizmann)APLP1
Ensembl hg19 (Hinxton)ENSG00000105290 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105290 [Gene_View]  ENSG00000105290 [Sequence]  chr19:35868445-35879797 [Contig_View]  APLP1 [Vega]
ICGC DataPortalENSG00000105290
TCGA cBioPortalAPLP1
AceView (NCBI)APLP1
Genatlas (Paris)APLP1
WikiGenes333
SOURCE (Princeton)APLP1
Genetics Home Reference (NIH)APLP1
Genomic and cartography
GoldenPath hg38 (UCSC)APLP1  -     chr19:35868445-35879797 +  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)APLP1  -     19q13.12   [Description]    (hg19-Feb_2009)
EnsemblAPLP1 - 19q13.12 [CytoView hg19]  APLP1 - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBIAPLP1 [Mapview hg19]  APLP1 [Mapview hg38]
OMIM104775   
Gene and transcription
Genbank (Entrez)AK092376 AK126907 AK297339 AK297640 AK312292
RefSeq transcript (Entrez)NM_001024807 NM_005166
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)APLP1
Cluster EST : UnigeneHs.74565 [ NCBI ]
CGAP (NCI)Hs.74565
Alternative Splicing GalleryENSG00000105290
Gene ExpressionAPLP1 [ NCBI-GEO ]   APLP1 [ EBI - ARRAY_EXPRESS ]   APLP1 [ SEEK ]   APLP1 [ MEM ]
Gene Expression Viewer (FireBrowse)APLP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)333
GTEX Portal (Tissue expression)APLP1
Human Protein AtlasENSG00000105290-APLP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51693   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51693  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51693
Splice isoforms : SwissVarP51693
PhosPhoSitePlusP51693
Domaine pattern : Prosite (Expaxy)A4_EXTRA (PS00319)    A4_INTRA (PS00320)   
Domains : Interpro (EBI)Amyloid_Cu-bd_sf    Amyloid_glyco    Amyloid_glyco_Cu-bd    Amyloid_glyco_E2_domain    Amyloid_glyco_extra    Amyloid_glyco_extracell_CS    Amyloid_glyco_heparin-bd    Amyloid_glyco_heparin-bd_sf    Amyloid_glyco_intracell_CS    APP_amyloid_C    E2_sf   
Domain families : Pfam (Sanger)APP_amyloid (PF10515)    APP_Cu_bd (PF12924)    APP_E2 (PF12925)    APP_N (PF02177)   
Domain families : Pfam (NCBI)pfam10515    pfam12924    pfam12925    pfam02177   
Domain families : Smart (EMBL)A4_EXTRA (SM00006)  
Conserved Domain (NCBI)APLP1
DMDM Disease mutations333
Blocks (Seattle)APLP1
PDB (RSDB)3PMR    3Q7G    3Q7L    3QMK    4RD9    4RDA   
PDB Europe3PMR    3Q7G    3Q7L    3QMK    4RD9    4RDA   
PDB (PDBSum)3PMR    3Q7G    3Q7L    3QMK    4RD9    4RDA   
PDB (IMB)3PMR    3Q7G    3Q7L    3QMK    4RD9    4RDA   
Structural Biology KnowledgeBase3PMR    3Q7G    3Q7L    3QMK    4RD9    4RDA   
SCOP (Structural Classification of Proteins)3PMR    3Q7G    3Q7L    3QMK    4RD9    4RDA   
CATH (Classification of proteins structures)3PMR    3Q7G    3Q7L    3QMK    4RD9    4RDA   
SuperfamilyP51693
Human Protein Atlas [tissue]ENSG00000105290-APLP1 [tissue]
Peptide AtlasP51693
HPRD00102
IPIIPI00020012   IPI00607600   
Protein Interaction databases
DIP (DOE-UCLA)P51693
IntAct (EBI)P51693
FunCoupENSG00000105290
BioGRIDAPLP1
STRING (EMBL)APLP1
ZODIACAPLP1
Ontologies - Pathways
QuickGOP51693
Ontology : AmiGOprotein binding  basement membrane  plasma membrane  endocytosis  apoptotic process  cell adhesion  nervous system development  heparin binding  animal organ morphogenesis  integral component of membrane  alpha-2A adrenergic receptor binding  alpha-2B adrenergic receptor binding  alpha-2C adrenergic receptor binding  identical protein binding  transition metal ion binding  perinuclear region of cytoplasm  cellular response to norepinephrine stimulus  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  
Ontology : EGO-EBIprotein binding  basement membrane  plasma membrane  endocytosis  apoptotic process  cell adhesion  nervous system development  heparin binding  animal organ morphogenesis  integral component of membrane  alpha-2A adrenergic receptor binding  alpha-2B adrenergic receptor binding  alpha-2C adrenergic receptor binding  identical protein binding  transition metal ion binding  perinuclear region of cytoplasm  cellular response to norepinephrine stimulus  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  
NDEx NetworkAPLP1
Atlas of Cancer Signalling NetworkAPLP1
Wikipedia pathwaysAPLP1
Orthology - Evolution
OrthoDB333
GeneTree (enSembl)ENSG00000105290
Phylogenetic Trees/Animal Genes : TreeFamAPLP1
HOGENOMP51693
Homologs : HomoloGeneAPLP1
Homology/Alignments : Family Browser (UCSC)APLP1
Gene fusions - Rearrangements
Fusion : QuiverAPLP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPLP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APLP1
dbVarAPLP1
ClinVarAPLP1
1000_GenomesAPLP1 
Exome Variant ServerAPLP1
ExAC (Exome Aggregation Consortium)ENSG00000105290
GNOMAD BrowserENSG00000105290
Varsome BrowserAPLP1
Genetic variants : HAPMAP333
Genomic Variants (DGV)APLP1 [DGVbeta]
DECIPHERAPLP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAPLP1 
Mutations
ICGC Data PortalAPLP1 
TCGA Data PortalAPLP1 
Broad Tumor PortalAPLP1
OASIS PortalAPLP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPLP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAPLP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APLP1
DgiDB (Drug Gene Interaction Database)APLP1
DoCM (Curated mutations)APLP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APLP1 (select a term)
intoGenAPLP1
Cancer3DAPLP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104775   
Orphanet
DisGeNETAPLP1
MedgenAPLP1
Genetic Testing Registry APLP1
NextProtP51693 [Medical]
TSGene333
GENETestsAPLP1
Target ValidationAPLP1
Huge Navigator APLP1 [HugePedia]
snp3D : Map Gene to Disease333
BioCentury BCIQAPLP1
ClinGenAPLP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD333
Chemical/Pharm GKB GenePA24884
Clinical trialAPLP1
Miscellaneous
canSAR (ICR)APLP1 (select the gene name)
DataMed IndexAPLP1
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPLP1
EVEXAPLP1
GoPubMedAPLP1
iHOPAPLP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:01:22 CET 2019

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