Atlas of Genetics and Cytogenetics in Oncology and Haematology

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APOA1 (apolipoprotein A1)

Identity

Alias (NCBI)HPALP2
apo(a)
HGNC (Hugo) APOA1
HGNC Previous nameapolipoprotein A-I
LocusID (NCBI) 335
Atlas_Id 43824
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 116835751 and ends at 116837950 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APOA1 (11q23.3) / DRAP1 (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)APOA1   600
LRG (Locus Reference Genomic)LRG_767
Cards
Entrez_Gene (NCBI)APOA1    apolipoprotein A1
AliasesHPALP2; apo(a)
GeneCards (Weizmann)APOA1
Ensembl hg19 (Hinxton)ENSG00000118137 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118137 [Gene_View]  ENSG00000118137 [Sequence]  chr11:116835751-116837950 [Contig_View]  APOA1 [Vega]
ICGC DataPortalENSG00000118137
TCGA cBioPortalAPOA1
AceView (NCBI)APOA1
Genatlas (Paris)APOA1
SOURCE (Princeton)APOA1
Genetics Home Reference (NIH)APOA1
Genomic and cartography
GoldenPath hg38 (UCSC)APOA1  -     chr11:116835751-116837950 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)APOA1  -     11q23.3   [Description]    (hg19-Feb_2009)
GoldenPathAPOA1 - 11q23.3 [CytoView hg19]  APOA1 - 11q23.3 [CytoView hg38]
ImmunoBaseENSG00000118137
genome Data Viewer NCBIAPOA1 [Mapview hg19]  
OMIM105200   107680   618463   
Gene and transcription
Genbank (Entrez)A14829 A15879 AK292231 AL531353 AL557908
RefSeq transcript (Entrez)NM_000039 NM_001318017 NM_001318018 NM_001318021
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)APOA1
Alternative Splicing GalleryENSG00000118137
Gene ExpressionAPOA1 [ NCBI-GEO ]   APOA1 [ EBI - ARRAY_EXPRESS ]   APOA1 [ SEEK ]   APOA1 [ MEM ]
Gene Expression Viewer (FireBrowse)APOA1 [ Firebrowse - Broad ]
GenevisibleExpression of APOA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)335
GTEX Portal (Tissue expression)APOA1
Human Protein AtlasENSG00000118137-APOA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02647   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02647  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02647
Splice isoforms : SwissVarP02647
PhosPhoSitePlusP02647
Domains : Interpro (EBI)ApoA_E   
Domain families : Pfam (Sanger)Apolipoprotein (PF01442)   
Domain families : Pfam (NCBI)pfam01442   
Conserved Domain (NCBI)APOA1
Blocks (Seattle)APOA1
PDB (RSDB)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2MSC    2MSD    2MSE    2N5E    3K2S    3R2P    4V6M    6CC9    6CCH    6CCX    6CLZ    6CM1    6PTS    6PTW    6W4E    6W4F   
PDB Europe1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2MSC    2MSD    2MSE    2N5E    3K2S    3R2P    4V6M    6CC9    6CCH    6CCX    6CLZ    6CM1    6PTS    6PTW    6W4E    6W4F   
PDB (PDBSum)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2MSC    2MSD    2MSE    2N5E    3K2S    3R2P    4V6M    6CC9    6CCH    6CCX    6CLZ    6CM1    6PTS    6PTW    6W4E    6W4F   
PDB (IMB)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2MSC    2MSD    2MSE    2N5E    3K2S    3R2P    4V6M    6CC9    6CCH    6CCX    6CLZ    6CM1    6PTS    6PTW    6W4E    6W4F   
Structural Biology KnowledgeBase1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2MSC    2MSD    2MSE    2N5E    3K2S    3R2P    4V6M    6CC9    6CCH    6CCX    6CLZ    6CM1    6PTS    6PTW    6W4E    6W4F   
SCOP (Structural Classification of Proteins)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2MSC    2MSD    2MSE    2N5E    3K2S    3R2P    4V6M    6CC9    6CCH    6CCX    6CLZ    6CM1    6PTS    6PTW    6W4E    6W4F   
CATH (Classification of proteins structures)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2MSC    2MSD    2MSE    2N5E    3K2S    3R2P    4V6M    6CC9    6CCH    6CCX    6CLZ    6CM1    6PTS    6PTW    6W4E    6W4F   
SuperfamilyP02647
Human Protein Atlas [tissue]ENSG00000118137-APOA1 [tissue]
Peptide AtlasP02647
HPRD02517
IPIIPI00021841   IPI00853525   
Protein Interaction databases
DIP (DOE-UCLA)P02647
IntAct (EBI)P02647
BioGRIDAPOA1
STRING (EMBL)APOA1
ZODIACAPOA1
Ontologies - Pathways
QuickGOP02647
Ontology : AmiGOretinoid metabolic process  amyloid-beta binding  amyloid-beta binding  regulation of protein phosphorylation  endothelial cell proliferation  platelet degranulation  negative regulation of cytokine production involved in immune response  signaling receptor binding  protein binding  phospholipid binding  phospholipid binding  extracellular region  extracellular region  extracellular space  extracellular space  extracellular space  nucleus  early endosome  endoplasmic reticulum lumen  cytosol  plasma membrane  phosphatidylcholine biosynthetic process  cholesterol biosynthetic process  receptor-mediated endocytosis  transforming growth factor beta receptor signaling pathway  G protein-coupled receptor signaling pathway  integrin-mediated signaling pathway  response to nutrient  high-density lipoprotein particle binding  cholesterol metabolic process  glucocorticoid metabolic process  cell surface  negative regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of cholesterol esterification  positive regulation of cholesterol esterification  positive regulation of cholesterol efflux  positive regulation of triglyceride catabolic process  negative regulation of very-low-density lipoprotein particle remodeling  peripheral nervous system axon regeneration  cholesterol binding  cholesterol binding  protein oxidation  peptidyl-methionine modification  regulation of lipid metabolic process  enzyme binding  lipid storage  endocytic vesicle  regulation of intestinal cholesterol absorption  cholesterol transport  adrenal gland development  heat shock protein binding  animal organ regeneration  phosphatidylcholine binding  cytoplasmic vesicle  regulation of Cdc42 protein signal transduction  negative regulation of interleukin-1 beta production  cholesterol efflux  cholesterol efflux  cholesterol efflux  phospholipid efflux  phospholipid efflux  negative regulation of heterotypic cell-cell adhesion  apolipoprotein receptor binding  apolipoprotein A-I receptor binding  very-low-density lipoprotein particle  low-density lipoprotein particle  intermediate-density lipoprotein particle  high-density lipoprotein particle  high-density lipoprotein particle  high-density lipoprotein particle  discoidal high-density lipoprotein particle  spherical high-density lipoprotein particle  chylomicron remodeling  very-low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  chylomicron assembly  high-density lipoprotein particle assembly  high-density lipoprotein particle assembly  high-density lipoprotein particle assembly  high-density lipoprotein particle clearance  high-density lipoprotein particle clearance  secretory granule lumen  positive regulation of Rho protein signal transduction  lipoprotein metabolic process  lipoprotein biosynthetic process  response to drug  chylomicron  cholesterol homeostasis  cholesterol homeostasis  cholesterol homeostasis  identical protein binding  blood vessel endothelial cell migration  response to estrogen  post-translational protein modification  reverse cholesterol transport  reverse cholesterol transport  cellular protein metabolic process  chemorepellent activity  positive regulation of fatty acid biosynthetic process  phosphatidylcholine metabolic process  positive regulation of lipid biosynthetic process  negative regulation of inflammatory response  positive regulation of phagocytosis  protein stabilization  negative chemotaxis  positive regulation of lipoprotein lipase activity  vitamin transport  positive regulation of hydrolase activity  positive regulation of stress fiber assembly  transmembrane transport  phospholipid homeostasis  lipase inhibitor activity  negative regulation of lipase activity  phosphatidylcholine-sterol O-acyltransferase activator activity  phosphatidylcholine-sterol O-acyltransferase activator activity  negative regulation of cell adhesion molecule production  negative regulation of response to cytokine stimulus  collagen-containing extracellular matrix  extracellular exosome  triglyceride homeostasis  triglyceride homeostasis  ERK1 and ERK2 cascade  cholesterol import  high-density lipoprotein particle receptor binding  high-density lipoprotein particle receptor binding  endocytic vesicle lumen  blood microparticle  intermembrane lipid transfer  cholesterol transfer activity  cholesterol transfer activity  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of phospholipid efflux  extracellular vesicle  
Ontology : EGO-EBIretinoid metabolic process  amyloid-beta binding  amyloid-beta binding  regulation of protein phosphorylation  endothelial cell proliferation  platelet degranulation  negative regulation of cytokine production involved in immune response  signaling receptor binding  protein binding  phospholipid binding  phospholipid binding  extracellular region  extracellular region  extracellular space  extracellular space  extracellular space  nucleus  early endosome  endoplasmic reticulum lumen  cytosol  plasma membrane  phosphatidylcholine biosynthetic process  cholesterol biosynthetic process  receptor-mediated endocytosis  transforming growth factor beta receptor signaling pathway  G protein-coupled receptor signaling pathway  integrin-mediated signaling pathway  response to nutrient  high-density lipoprotein particle binding  cholesterol metabolic process  glucocorticoid metabolic process  cell surface  negative regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of cholesterol esterification  positive regulation of cholesterol esterification  positive regulation of cholesterol efflux  positive regulation of triglyceride catabolic process  negative regulation of very-low-density lipoprotein particle remodeling  peripheral nervous system axon regeneration  cholesterol binding  cholesterol binding  protein oxidation  peptidyl-methionine modification  regulation of lipid metabolic process  enzyme binding  lipid storage  endocytic vesicle  regulation of intestinal cholesterol absorption  cholesterol transport  adrenal gland development  heat shock protein binding  animal organ regeneration  phosphatidylcholine binding  cytoplasmic vesicle  regulation of Cdc42 protein signal transduction  negative regulation of interleukin-1 beta production  cholesterol efflux  cholesterol efflux  cholesterol efflux  phospholipid efflux  phospholipid efflux  negative regulation of heterotypic cell-cell adhesion  apolipoprotein receptor binding  apolipoprotein A-I receptor binding  very-low-density lipoprotein particle  low-density lipoprotein particle  intermediate-density lipoprotein particle  high-density lipoprotein particle  high-density lipoprotein particle  high-density lipoprotein particle  discoidal high-density lipoprotein particle  spherical high-density lipoprotein particle  chylomicron remodeling  very-low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  chylomicron assembly  high-density lipoprotein particle assembly  high-density lipoprotein particle assembly  high-density lipoprotein particle assembly  high-density lipoprotein particle clearance  high-density lipoprotein particle clearance  secretory granule lumen  positive regulation of Rho protein signal transduction  lipoprotein metabolic process  lipoprotein biosynthetic process  response to drug  chylomicron  cholesterol homeostasis  cholesterol homeostasis  cholesterol homeostasis  identical protein binding  blood vessel endothelial cell migration  response to estrogen  post-translational protein modification  reverse cholesterol transport  reverse cholesterol transport  cellular protein metabolic process  chemorepellent activity  positive regulation of fatty acid biosynthetic process  phosphatidylcholine metabolic process  positive regulation of lipid biosynthetic process  negative regulation of inflammatory response  positive regulation of phagocytosis  protein stabilization  negative chemotaxis  positive regulation of lipoprotein lipase activity  vitamin transport  positive regulation of hydrolase activity  positive regulation of stress fiber assembly  transmembrane transport  phospholipid homeostasis  lipase inhibitor activity  negative regulation of lipase activity  phosphatidylcholine-sterol O-acyltransferase activator activity  phosphatidylcholine-sterol O-acyltransferase activator activity  negative regulation of cell adhesion molecule production  negative regulation of response to cytokine stimulus  collagen-containing extracellular matrix  extracellular exosome  triglyceride homeostasis  triglyceride homeostasis  ERK1 and ERK2 cascade  cholesterol import  high-density lipoprotein particle receptor binding  high-density lipoprotein particle receptor binding  endocytic vesicle lumen  blood microparticle  intermembrane lipid transfer  cholesterol transfer activity  cholesterol transfer activity  positive regulation of substrate adhesion-dependent cell spreading  positive regulation of phospholipid efflux  extracellular vesicle  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]   
Pathways : KEGGPPAR signaling pathway    Fat digestion and absorption    Vitamin digestion and absorption    African trypanosomiasis   
NDEx NetworkAPOA1
Atlas of Cancer Signalling NetworkAPOA1
Wikipedia pathwaysAPOA1
Orthology - Evolution
OrthoDB335
GeneTree (enSembl)ENSG00000118137
Phylogenetic Trees/Animal Genes : TreeFamAPOA1
HOGENOMP02647
Homologs : HomoloGeneAPOA1
Homology/Alignments : Family Browser (UCSC)APOA1
Gene fusions - Rearrangements
Fusion : QuiverAPOA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPOA1 [hg38]
dbVarAPOA1
ClinVarAPOA1
MonarchAPOA1
1000_GenomesAPOA1 
Exome Variant ServerAPOA1
GNOMAD BrowserENSG00000118137
Varsome BrowserAPOA1
Genomic Variants (DGV)APOA1 [DGVbeta]
DECIPHERAPOA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAPOA1 
Mutations
ICGC Data PortalAPOA1 
TCGA Data PortalAPOA1 
Broad Tumor PortalAPOA1
OASIS PortalAPOA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPOA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAPOA1
Mutations and Diseases : HGMDAPOA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APOA1
DgiDB (Drug Gene Interaction Database)APOA1
DoCM (Curated mutations)APOA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APOA1 (select a term)
intoGenAPOA1
Cancer3DAPOA1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM105200    107680    618463   
Orphanet2927    12402   
DisGeNETAPOA1
MedgenAPOA1
Genetic Testing Registry APOA1
NextProtP02647 [Medical]
GENETestsAPOA1
Target ValidationAPOA1
Huge Navigator APOA1 [HugePedia]
ClinGenAPOA1
Clinical trials, drugs, therapy
MyCancerGenomeAPOA1
Protein Interactions : CTD
Pharm GKB GenePA49
Pharm GKB PathwaysPA2031   
PharosP02647
Clinical trialAPOA1
Miscellaneous
canSAR (ICR)APOA1 (select the gene name)
HarmonizomeAPOA1
DataMed IndexAPOA1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXAPOA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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