Atlas of Genetics and Cytogenetics in Oncology and Haematology


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APOA1 (apolipoprotein A-I)

Identity

Other namesapo(a)
HGNC (Hugo) APOA1
LocusID (NCBI) 335
Atlas_Id 43824
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 116706467 and ends at 116708666 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
APOA1 (11q23.3) / DRAP1 (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)APOA1   600
Cards
Entrez_Gene (NCBI)APOA1  335  apolipoprotein A-I
Aliasesapo(a)
GeneCards (Weizmann)APOA1
Ensembl hg19 (Hinxton)ENSG00000118137 [Gene_View]  chr11:116706467-116708666 [Contig_View]  APOA1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000118137 [Gene_View]  chr11:116706467-116708666 [Contig_View]  APOA1 [Vega]
ICGC DataPortalENSG00000118137
TCGA cBioPortalAPOA1
AceView (NCBI)APOA1
Genatlas (Paris)APOA1
WikiGenes335
SOURCE (Princeton)APOA1
Genomic and cartography
GoldenPath hg19 (UCSC)APOA1  -     chr11:116706467-116708666 -  11q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)APOA1  -     11q23.3   [Description]    (hg38-Dec_2013)
EnsemblAPOA1 - 11q23.3 [CytoView hg19]  APOA1 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIAPOA1 [Mapview hg19]  APOA1 [Mapview hg38]
OMIM105200   107680   604091   
Gene and transcription
Genbank (Entrez)A14829 A15879 AK292231 AL531353 AL557908
RefSeq transcript (Entrez)NM_000039 NM_001318017 NM_001318018 NM_001318021
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_012021 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)APOA1
Cluster EST : UnigeneHs.93194 [ NCBI ]
CGAP (NCI)Hs.93194
Alternative Splicing GalleryENSG00000118137
Gene ExpressionAPOA1 [ NCBI-GEO ]   APOA1 [ EBI - ARRAY_EXPRESS ]   APOA1 [ SEEK ]   APOA1 [ MEM ]
Gene Expression Viewer (FireBrowse)APOA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)335
GTEX Portal (Tissue expression)APOA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02647 (Uniprot)
NextProtP02647  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02647
Splice isoforms : SwissVarP02647 (Swissvar)
PhosPhoSitePlusP02647
Domains : Interpro (EBI)ApoA_E   
Domain families : Pfam (Sanger)Apolipoprotein (PF01442)   
Domain families : Pfam (NCBI)pfam01442   
DMDM Disease mutations335
Blocks (Seattle)APOA1
PDB (SRS)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    2MSC    2MSD    2MSE    3K2S    3R2P    4V6M   
PDB (PDBSum)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    2MSC    2MSD    2MSE    3K2S    3R2P    4V6M   
PDB (IMB)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    2MSC    2MSD    2MSE    3K2S    3R2P    4V6M   
PDB (RSDB)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    2MSC    2MSD    2MSE    3K2S    3R2P    4V6M   
Structural Biology KnowledgeBase1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    2MSC    2MSD    2MSE    3K2S    3R2P    4V6M   
SCOP (Structural Classification of Proteins)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    2MSC    2MSD    2MSE    3K2S    3R2P    4V6M   
CATH (Classification of proteins structures)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    2MSC    2MSD    2MSE    3K2S    3R2P    4V6M   
SuperfamilyP02647
Human Protein AtlasENSG00000118137
Peptide AtlasP02647
HPRD02517
IPIIPI00021841   IPI00853525   
Protein Interaction databases
DIP (DOE-UCLA)P02647
IntAct (EBI)P02647
FunCoupENSG00000118137
BioGRIDAPOA1
STRING (EMBL)APOA1
ZODIACAPOA1
Ontologies - Pathways
QuickGOP02647
Ontology : AmiGOretinoid metabolic process  beta-amyloid binding  regulation of protein phosphorylation  endothelial cell proliferation  platelet degranulation  negative regulation of cytokine secretion involved in immune response  protein binding  phospholipid binding  phospholipid transporter activity  extracellular region  extracellular space  extracellular space  nucleus  early endosome  endoplasmic reticulum lumen  cytosol  plasma membrane  phosphatidylcholine biosynthetic process  cholesterol biosynthetic process  receptor-mediated endocytosis  transforming growth factor beta receptor signaling pathway  G-protein coupled receptor signaling pathway  integrin-mediated signaling pathway  response to nutrient  high-density lipoprotein particle binding  cholesterol metabolic process  glucocorticoid metabolic process  cell surface  negative regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of cholesterol esterification  positive regulation of triglyceride catabolic process  negative regulation of very-low-density lipoprotein particle remodeling  peripheral nervous system axon regeneration  cholesterol binding  cholesterol transporter activity  cholesterol transporter activity  protein oxidation  peptidyl-methionine modification  triglyceride catabolic process  enzyme binding  lipid storage  endocytic vesicle  regulation of intestinal cholesterol absorption  cholesterol transport  adrenal gland development  organ regeneration  neuron projection regeneration  phosphatidylcholine binding  cytoplasmic vesicle  regulation of Cdc42 protein signal transduction  cholesterol efflux  cholesterol efflux  phospholipid efflux  negative regulation of heterotypic cell-cell adhesion  apolipoprotein receptor binding  apolipoprotein A-I receptor binding  very-low-density lipoprotein particle  high-density lipoprotein particle  discoidal high-density lipoprotein particle  spherical high-density lipoprotein particle  high-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  high-density lipoprotein particle clearance  secretory granule lumen  positive regulation of Rho protein signal transduction  lipoprotein metabolic process  lipoprotein metabolic process  lipoprotein biosynthetic process  response to drug  chylomicron  cholesterol homeostasis  cholesterol homeostasis  identical protein binding  blood vessel endothelial cell migration  response to estrogen  reverse cholesterol transport  cellular protein metabolic process  chemorepellent activity  positive regulation of fatty acid biosynthetic process  negative regulation of interleukin-1 beta secretion  negative regulation of inflammatory response  protein stabilization  negative chemotaxis  positive regulation of lipoprotein lipase activity  vitamin transport  positive regulation of hydrolase activity  positive regulation of stress fiber assembly  transmembrane transport  phospholipid homeostasis  lipase inhibitor activity  negative regulation of lipase activity  phosphatidylcholine-sterol O-acyltransferase activator activity  negative regulation of cell adhesion molecule production  negative regulation of response to cytokine stimulus  extracellular exosome  triglyceride homeostasis  ERK1 and ERK2 cascade  cholesterol import  high-density lipoprotein particle receptor binding  endocytic vesicle lumen  blood microparticle  positive regulation of substrate adhesion-dependent cell spreading  extracellular vesicle  
Ontology : EGO-EBIretinoid metabolic process  beta-amyloid binding  regulation of protein phosphorylation  endothelial cell proliferation  platelet degranulation  negative regulation of cytokine secretion involved in immune response  protein binding  phospholipid binding  phospholipid transporter activity  extracellular region  extracellular space  extracellular space  nucleus  early endosome  endoplasmic reticulum lumen  cytosol  plasma membrane  phosphatidylcholine biosynthetic process  cholesterol biosynthetic process  receptor-mediated endocytosis  transforming growth factor beta receptor signaling pathway  G-protein coupled receptor signaling pathway  integrin-mediated signaling pathway  response to nutrient  high-density lipoprotein particle binding  cholesterol metabolic process  glucocorticoid metabolic process  cell surface  negative regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of cholesterol esterification  positive regulation of triglyceride catabolic process  negative regulation of very-low-density lipoprotein particle remodeling  peripheral nervous system axon regeneration  cholesterol binding  cholesterol transporter activity  cholesterol transporter activity  protein oxidation  peptidyl-methionine modification  triglyceride catabolic process  enzyme binding  lipid storage  endocytic vesicle  regulation of intestinal cholesterol absorption  cholesterol transport  adrenal gland development  organ regeneration  neuron projection regeneration  phosphatidylcholine binding  cytoplasmic vesicle  regulation of Cdc42 protein signal transduction  cholesterol efflux  cholesterol efflux  phospholipid efflux  negative regulation of heterotypic cell-cell adhesion  apolipoprotein receptor binding  apolipoprotein A-I receptor binding  very-low-density lipoprotein particle  high-density lipoprotein particle  discoidal high-density lipoprotein particle  spherical high-density lipoprotein particle  high-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  high-density lipoprotein particle clearance  secretory granule lumen  positive regulation of Rho protein signal transduction  lipoprotein metabolic process  lipoprotein metabolic process  lipoprotein biosynthetic process  response to drug  chylomicron  cholesterol homeostasis  cholesterol homeostasis  identical protein binding  blood vessel endothelial cell migration  response to estrogen  reverse cholesterol transport  cellular protein metabolic process  chemorepellent activity  positive regulation of fatty acid biosynthetic process  negative regulation of interleukin-1 beta secretion  negative regulation of inflammatory response  protein stabilization  negative chemotaxis  positive regulation of lipoprotein lipase activity  vitamin transport  positive regulation of hydrolase activity  positive regulation of stress fiber assembly  transmembrane transport  phospholipid homeostasis  lipase inhibitor activity  negative regulation of lipase activity  phosphatidylcholine-sterol O-acyltransferase activator activity  negative regulation of cell adhesion molecule production  negative regulation of response to cytokine stimulus  extracellular exosome  triglyceride homeostasis  ERK1 and ERK2 cascade  cholesterol import  high-density lipoprotein particle receptor binding  endocytic vesicle lumen  blood microparticle  positive regulation of substrate adhesion-dependent cell spreading  extracellular vesicle  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]   
Pathways : KEGGPPAR signaling pathway    Fat digestion and absorption    Vitamin digestion and absorption    African trypanosomiasis   
NDEx Network
Atlas of Cancer Signalling NetworkAPOA1
Wikipedia pathwaysAPOA1
Orthology - Evolution
OrthoDB335
GeneTree (enSembl)ENSG00000118137
Phylogenetic Trees/Animal Genes : TreeFamAPOA1
Homologs : HomoloGeneAPOA1
Homology/Alignments : Family Browser (UCSC)APOA1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerAPOA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APOA1
dbVarAPOA1
ClinVarAPOA1
1000_GenomesAPOA1 
Exome Variant ServerAPOA1
ExAC (Exome Aggregation Consortium)APOA1 (select the gene name)
Genetic variants : HAPMAP335
Genomic Variants (DGV)APOA1 [DGVbeta]
Mutations
ICGC Data PortalAPOA1 
TCGA Data PortalAPOA1 
Broad Tumor PortalAPOA1
OASIS PortalAPOA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPOA1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APOA1
DgiDB (Drug Gene Interaction Database)APOA1
DoCM (Curated mutations)APOA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APOA1 (select a term)
intoGenAPOA1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:116706467-116708666  ENSG00000118137
CONAN: Copy Number AnalysisAPOA1 
Mutations and Diseases : HGMDAPOA1
OMIM105200    107680    604091   
MedgenAPOA1
Genetic Testing Registry APOA1
NextProtP02647 [Medical]
TSGene335
GENETestsAPOA1
Huge Navigator APOA1 [HugePedia]
snp3D : Map Gene to Disease335
BioCentury BCIQAPOA1
ClinGenAPOA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD335
Chemical/Pharm GKB GenePA49
Clinical trialAPOA1
Miscellaneous
canSAR (ICR)APOA1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPOA1
EVEXAPOA1
GoPubMedAPOA1
iHOPAPOA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 18:58:55 CEST 2016

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