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APOA1 (apolipoprotein A-I)

Identity

Other names-
HGNC (Hugo) APOA1
LocusID (NCBI) 335
Location 11q23.3
Location_base_pair Starts at 116706469 and ends at 116708338 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)APOA1   600
Cards
Entrez_Gene (NCBI)APOA1  335  apolipoprotein A-I
GeneCards (Weizmann)APOA1
Ensembl (Hinxton)ENSG00000118137 [Gene_View]  chr11:116706469-116708338 [Contig_View]  APOA1 [Vega]
ICGC DataPortalENSG00000118137
cBioPortalAPOA1
AceView (NCBI)APOA1
Genatlas (Paris)APOA1
WikiGenes335
SOURCE (Princeton)NM_000039
Genomic and cartography
GoldenPath (UCSC)APOA1  -  11q23.3   chr11:116706469-116708338 -  11q23.3   [Description]    (hg19-Feb_2009)
EnsemblAPOA1 - 11q23.3 [CytoView]
Mapping of homologs : NCBIAPOA1 [Mapview]
OMIM105200   107680   604091   
Gene and transcription
Genbank (Entrez)A14829 A15879 AK292231 BC005380 BC110286
RefSeq transcript (Entrez)NM_000039
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_012021 NT_033899 NW_001838042 NW_004929381
Consensus coding sequences : CCDS (NCBI)APOA1
Cluster EST : UnigeneHs.93194 [ NCBI ]
CGAP (NCI)Hs.93194
Alternative Splicing : Fast-db (Paris)GSHG0006208
Alternative Splicing GalleryENSG00000118137
Gene ExpressionAPOA1 [ NCBI-GEO ]     APOA1 [ SEEK ]   APOA1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02647 (Uniprot)
NextProtP02647  [Medical]
With graphics : InterProP02647
Splice isoforms : SwissVarP02647 (Swissvar)
Domains : Interpro (EBI)ApoA1_A4_E [organisation]  
Related proteins : CluSTrP02647
Domain families : Pfam (Sanger)Apolipoprotein (PF01442)   
Domain families : Pfam (NCBI)pfam01442   
DMDM Disease mutations335
Blocks (Seattle)P02647
PDB (SRS)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    3J00    3K2S    3R2P   
PDB (PDBSum)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    3J00    3K2S    3R2P   
PDB (IMB)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    3J00    3K2S    3R2P   
PDB (RSDB)1AV1    1GW3    1GW4    1ODP    1ODQ    1ODR    2A01    3J00    3K2S    3R2P   
Human Protein AtlasENSG00000118137 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP02647
HPRD02517
IPIIPI00021841   IPI00853525   
Protein Interaction databases
DIP (DOE-UCLA)P02647
IntAct (EBI)P02647
FunCoupENSG00000118137
BioGRIDAPOA1
InParanoidP02647
Interologous Interaction database P02647
IntegromeDBAPOA1
STRING (EMBL)APOA1
Ontologies - Pathways
Ontology : AmiGOretinoid metabolic process  beta-amyloid binding  regulation of protein phosphorylation  endothelial cell proliferation  platelet degranulation  negative regulation of cytokine secretion involved in immune response  protein binding  phospholipid binding  phospholipid transporter activity  extracellular region  extracellular space  extracellular space  nucleus  early endosome  endoplasmic reticulum lumen  cytosol  plasma membrane  phosphatidylcholine biosynthetic process  cholesterol biosynthetic process  G-protein coupled receptor signaling pathway  response to nutrient  blood coagulation  phototransduction, visible light  high-density lipoprotein particle binding  cholesterol metabolic process  glucocorticoid metabolic process  negative regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of cholesterol esterification  negative regulation of very-low-density lipoprotein particle remodeling  peripheral nervous system axon regeneration  cholesterol binding  cholesterol transporter activity  cholesterol transporter activity  protein oxidation  peptidyl-methionine modification  enzyme binding  lipid storage  endocytic vesicle  platelet activation  regulation of intestinal cholesterol absorption  cholesterol transport  adrenal gland development  organ regeneration  cytoplasmic vesicle  regulation of Cdc42 protein signal transduction  cholesterol efflux  phospholipid efflux  negative regulation of heterotypic cell-cell adhesion  apolipoprotein receptor binding  apolipoprotein A-I receptor binding  very-low-density lipoprotein particle  high-density lipoprotein particle  spherical high-density lipoprotein particle  high-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  high-density lipoprotein particle clearance  secretory granule lumen  lipoprotein metabolic process  lipoprotein biosynthetic process  response to drug  cholesterol homeostasis  cholesterol homeostasis  identical protein binding  blood vessel endothelial cell migration  response to estrogen  reverse cholesterol transport  cellular lipid metabolic process  small molecule metabolic process  negative regulation of interleukin-1 beta secretion  negative regulation of inflammatory response  protein stabilization  positive regulation of hydrolase activity  positive regulation of transferase activity  transmembrane transport  phospholipid homeostasis  lipase inhibitor activity  negative regulation of lipase activity  phosphatidylcholine-sterol O-acyltransferase activator activity  negative regulation of cell adhesion molecule production  negative regulation of response to cytokine stimulus  extracellular vesicular exosome  triglyceride homeostasis  cholesterol import  high-density lipoprotein particle receptor binding  endocytic vesicle lumen  blood microparticle  
Ontology : EGO-EBIretinoid metabolic process  beta-amyloid binding  regulation of protein phosphorylation  endothelial cell proliferation  platelet degranulation  negative regulation of cytokine secretion involved in immune response  protein binding  phospholipid binding  phospholipid transporter activity  extracellular region  extracellular space  extracellular space  nucleus  early endosome  endoplasmic reticulum lumen  cytosol  plasma membrane  phosphatidylcholine biosynthetic process  cholesterol biosynthetic process  G-protein coupled receptor signaling pathway  response to nutrient  blood coagulation  phototransduction, visible light  high-density lipoprotein particle binding  cholesterol metabolic process  glucocorticoid metabolic process  negative regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of cholesterol esterification  negative regulation of very-low-density lipoprotein particle remodeling  peripheral nervous system axon regeneration  cholesterol binding  cholesterol transporter activity  cholesterol transporter activity  protein oxidation  peptidyl-methionine modification  enzyme binding  lipid storage  endocytic vesicle  platelet activation  regulation of intestinal cholesterol absorption  cholesterol transport  adrenal gland development  organ regeneration  cytoplasmic vesicle  regulation of Cdc42 protein signal transduction  cholesterol efflux  phospholipid efflux  negative regulation of heterotypic cell-cell adhesion  apolipoprotein receptor binding  apolipoprotein A-I receptor binding  very-low-density lipoprotein particle  high-density lipoprotein particle  spherical high-density lipoprotein particle  high-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  high-density lipoprotein particle clearance  secretory granule lumen  lipoprotein metabolic process  lipoprotein biosynthetic process  response to drug  cholesterol homeostasis  cholesterol homeostasis  identical protein binding  blood vessel endothelial cell migration  response to estrogen  reverse cholesterol transport  cellular lipid metabolic process  small molecule metabolic process  negative regulation of interleukin-1 beta secretion  negative regulation of inflammatory response  protein stabilization  positive regulation of hydrolase activity  positive regulation of transferase activity  transmembrane transport  phospholipid homeostasis  lipase inhibitor activity  negative regulation of lipase activity  phosphatidylcholine-sterol O-acyltransferase activator activity  negative regulation of cell adhesion molecule production  negative regulation of response to cytokine stimulus  extracellular vesicular exosome  triglyceride homeostasis  cholesterol import  high-density lipoprotein particle receptor binding  endocytic vesicle lumen  blood microparticle  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]   
Pathways : KEGGPPAR signaling pathway    Fat digestion and absorption    Vitamin digestion and absorption    African trypanosomiasis   
Protein Interaction DatabaseAPOA1
Wikipedia pathwaysAPOA1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)APOA1
snp3D : Map Gene to Disease335
SNP (GeneSNP Utah)APOA1
SNP : HGBaseAPOA1
Genetic variants : HAPMAPAPOA1
Exome VariantAPOA1
1000_GenomesAPOA1 
ICGC programENSG00000118137 
Somatic Mutations in Cancer : COSMICAPOA1 
CONAN: Copy Number AnalysisAPOA1 
Mutations and Diseases : HGMDAPOA1
Mutations and Diseases : intOGenAPOA1
Genomic VariantsAPOA1  APOA1 [DGVbeta]
dbVarAPOA1
ClinVarAPOA1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM105200    107680    604091   
MedgenAPOA1
GENETestsAPOA1
Disease Genetic AssociationAPOA1
Huge Navigator APOA1 [HugePedia]  APOA1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneAPOA1
Homology/Alignments : Family Browser (UCSC)APOA1
Phylogenetic Trees/Animal Genes : TreeFamAPOA1
Chemical/Protein Interactions : CTD335
Chemical/Pharm GKB GenePA49
Clinical trialAPOA1
Cancer Resource (Charite)ENSG00000118137
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineAPOA1
iHOPAPOA1
OncoSearchAPOA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:38:21 CEST 2014

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