APOA4 (apolipoprotein A4)

2009-06-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 337
MIM: 107690
HGNC: 602
Ensembl: ENSG00000110244

Variants:

dbSNP: 337
ClinVar: 337
TCGA: ENSG00000110244
COSMIC: APOA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110244ENST00000357780P06727

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Vitamin digestion and absorptionKEGGko04977
Vitamin digestion and absorptionKEGGhsa04977
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA273PLTPGenePathwayassociated

References

Pubmed IDYearTitleCitations
181930432008Newly identified loci that influence lipid concentrations and risk of coronary artery disease.690
207143482010Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.246
166028262006Lipoprotein genotype and conserved pathway for exceptional longevity in humans.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
124175252002Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.75
124175252002Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides.75
152545932004Apolipoprotein A-IV inhibits experimental colitis.54
178558072007Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery.36
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32

Citation

Dessen P

APOA4 (apolipoprotein A4)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50976/apoa4