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APOA4 (apolipoprotein A4)

Identity

Alias_namesapolipoprotein A-IV
Other alias-
HGNC (Hugo) APOA4
LocusID (NCBI) 337
Atlas_Id 50976
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 116820702 and ends at 116823295 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)APOA4   602
Cards
Entrez_Gene (NCBI)APOA4  337  apolipoprotein A4
Aliases
GeneCards (Weizmann)APOA4
Ensembl hg19 (Hinxton)ENSG00000110244 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110244 [Gene_View]  chr11:116820702-116823295 [Contig_View]  APOA4 [Vega]
ICGC DataPortalENSG00000110244
TCGA cBioPortalAPOA4
AceView (NCBI)APOA4
Genatlas (Paris)APOA4
WikiGenes337
SOURCE (Princeton)APOA4
Genetics Home Reference (NIH)APOA4
Genomic and cartography
GoldenPath hg38 (UCSC)APOA4  -     chr11:116820702-116823295 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)APOA4  -     11q23.3   [Description]    (hg19-Feb_2009)
EnsemblAPOA4 - 11q23.3 [CytoView hg19]  APOA4 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIAPOA4 [Mapview hg19]  APOA4 [Mapview hg38]
OMIM107690   
Gene and transcription
Genbank (Entrez)AL531739 BC074764 BC113594 BC113596 HQ258218
RefSeq transcript (Entrez)NM_000482
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)APOA4
Cluster EST : UnigeneHs.1247 [ NCBI ]
CGAP (NCI)Hs.1247
Alternative Splicing GalleryENSG00000110244
Gene ExpressionAPOA4 [ NCBI-GEO ]   APOA4 [ EBI - ARRAY_EXPRESS ]   APOA4 [ SEEK ]   APOA4 [ MEM ]
Gene Expression Viewer (FireBrowse)APOA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)337
GTEX Portal (Tissue expression)APOA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06727   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06727  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06727
Splice isoforms : SwissVarP06727
PhosPhoSitePlusP06727
Domains : Interpro (EBI)ApoA_E   
Domain families : Pfam (Sanger)Apolipoprotein (PF01442)   
Domain families : Pfam (NCBI)pfam01442   
Conserved Domain (NCBI)APOA4
DMDM Disease mutations337
Blocks (Seattle)APOA4
PDB (SRS)3S84   
PDB (PDBSum)3S84   
PDB (IMB)3S84   
PDB (RSDB)3S84   
Structural Biology KnowledgeBase3S84   
SCOP (Structural Classification of Proteins)3S84   
CATH (Classification of proteins structures)3S84   
SuperfamilyP06727
Human Protein AtlasENSG00000110244
Peptide AtlasP06727
HPRD00130
IPIIPI00304273   
Protein Interaction databases
DIP (DOE-UCLA)P06727
IntAct (EBI)P06727
FunCoupENSG00000110244
BioGRIDAPOA4
STRING (EMBL)APOA4
ZODIACAPOA4
Ontologies - Pathways
QuickGOP06727
Ontology : AmiGOretinoid metabolic process  innate immune response in mucosa  lipid transporter activity  copper ion binding  protein binding  extracellular region  extracellular region  extracellular space  early endosome  endoplasmic reticulum lumen  cytosol  cholesterol biosynthetic process  lipid transport  response to lipid hydroperoxide  leukocyte cell-cell adhesion  cholesterol metabolic process  lipid binding  cell surface  positive regulation of cholesterol esterification  positive regulation of triglyceride catabolic process  cholesterol binding  antioxidant activity  cholesterol transporter activity  removal of superoxide radicals  regulation of intestinal cholesterol absorption  neuron projection regeneration  phosphatidylcholine binding  regulation of cholesterol transport  cholesterol efflux  phospholipid efflux  very-low-density lipoprotein particle  high-density lipoprotein particle  chylomicron remodeling  very-low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  chylomicron assembly  high-density lipoprotein particle assembly  negative regulation of plasma lipoprotein oxidation  response to stilbenoid  lipoprotein metabolic process  lipoprotein biosynthetic process  chylomicron  cholesterol homeostasis  hydrogen peroxide catabolic process  protein homodimerization activity  reverse cholesterol transport  multicellular organismal lipid catabolic process  cellular protein metabolic process  positive regulation of fatty acid biosynthetic process  phosphatidylcholine metabolic process  positive regulation of lipoprotein lipase activity  lipid homeostasis  phosphatidylcholine-sterol O-acyltransferase activator activity  protein-lipid complex assembly  extracellular exosome  triglyceride homeostasis  blood microparticle  
Ontology : EGO-EBIretinoid metabolic process  innate immune response in mucosa  lipid transporter activity  copper ion binding  protein binding  extracellular region  extracellular region  extracellular space  early endosome  endoplasmic reticulum lumen  cytosol  cholesterol biosynthetic process  lipid transport  response to lipid hydroperoxide  leukocyte cell-cell adhesion  cholesterol metabolic process  lipid binding  cell surface  positive regulation of cholesterol esterification  positive regulation of triglyceride catabolic process  cholesterol binding  antioxidant activity  cholesterol transporter activity  removal of superoxide radicals  regulation of intestinal cholesterol absorption  neuron projection regeneration  phosphatidylcholine binding  regulation of cholesterol transport  cholesterol efflux  phospholipid efflux  very-low-density lipoprotein particle  high-density lipoprotein particle  chylomicron remodeling  very-low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  chylomicron assembly  high-density lipoprotein particle assembly  negative regulation of plasma lipoprotein oxidation  response to stilbenoid  lipoprotein metabolic process  lipoprotein biosynthetic process  chylomicron  cholesterol homeostasis  hydrogen peroxide catabolic process  protein homodimerization activity  reverse cholesterol transport  multicellular organismal lipid catabolic process  cellular protein metabolic process  positive regulation of fatty acid biosynthetic process  phosphatidylcholine metabolic process  positive regulation of lipoprotein lipase activity  lipid homeostasis  phosphatidylcholine-sterol O-acyltransferase activator activity  protein-lipid complex assembly  extracellular exosome  triglyceride homeostasis  blood microparticle  
Pathways : KEGGFat digestion and absorption    Vitamin digestion and absorption   
NDEx NetworkAPOA4
Atlas of Cancer Signalling NetworkAPOA4
Wikipedia pathwaysAPOA4
Orthology - Evolution
OrthoDB337
GeneTree (enSembl)ENSG00000110244
Phylogenetic Trees/Animal Genes : TreeFamAPOA4
HOVERGENP06727
HOGENOMP06727
Homologs : HomoloGeneAPOA4
Homology/Alignments : Family Browser (UCSC)APOA4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPOA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APOA4
dbVarAPOA4
ClinVarAPOA4
1000_GenomesAPOA4 
Exome Variant ServerAPOA4
ExAC (Exome Aggregation Consortium)APOA4 (select the gene name)
Genetic variants : HAPMAP337
Genomic Variants (DGV)APOA4 [DGVbeta]
DECIPHERAPOA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAPOA4 
Mutations
ICGC Data PortalAPOA4 
TCGA Data PortalAPOA4 
Broad Tumor PortalAPOA4
OASIS PortalAPOA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPOA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAPOA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APOA4
DgiDB (Drug Gene Interaction Database)APOA4
DoCM (Curated mutations)APOA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APOA4 (select a term)
intoGenAPOA4
Cancer3DAPOA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107690   
Orphanet
MedgenAPOA4
Genetic Testing Registry APOA4
NextProtP06727 [Medical]
TSGene337
GENETestsAPOA4
Target ValidationAPOA4
Huge Navigator APOA4 [HugePedia]
snp3D : Map Gene to Disease337
BioCentury BCIQAPOA4
ClinGenAPOA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD337
Chemical/Pharm GKB GenePA24887
Clinical trialAPOA4
Miscellaneous
canSAR (ICR)APOA4 (select the gene name)
Probes
Litterature
PubMed186 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPOA4
EVEXAPOA4
GoPubMedAPOA4
iHOPAPOA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 18:57:34 CEST 2017

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