Atlas of Genetics and Cytogenetics in Oncology and Haematology

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APOA5 (apolipoprotein A5)

Identity

Alias (NCBI)APOAV
RAP3
HGNC (Hugo) APOA5
HGNC Alias symbRAP3
APOA-V
HGNC Previous nameapolipoprotein A-V
LocusID (NCBI) 116519
Atlas_Id 60424
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 116789370 and ends at 116792420 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BUD13 (11q23.3) / APOA5 (11q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  BUD13/APOA5 (11q23)

External links

Nomenclature
HGNC (Hugo)APOA5   17288
Cards
Entrez_Gene (NCBI)APOA5    apolipoprotein A5
AliasesAPOAV; RAP3
GeneCards (Weizmann)APOA5
Ensembl hg19 (Hinxton)ENSG00000110243 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110243 [Gene_View]  ENSG00000110243 [Sequence]  chr11:116789370-116792420 [Contig_View]  APOA5 [Vega]
ICGC DataPortalENSG00000110243
TCGA cBioPortalAPOA5
AceView (NCBI)APOA5
Genatlas (Paris)APOA5
SOURCE (Princeton)APOA5
Genetics Home Reference (NIH)APOA5
Genomic and cartography
GoldenPath hg38 (UCSC)APOA5  -     chr11:116789370-116792420 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)APOA5  -     11q23.3   [Description]    (hg19-Feb_2009)
GoldenPathAPOA5 - 11q23.3 [CytoView hg19]  APOA5 - 11q23.3 [CytoView hg38]
ImmunoBaseENSG00000110243
genome Data Viewer NCBIAPOA5 [Mapview hg19]  
OMIM144650   145750   606368   
Gene and transcription
Genbank (Entrez)AF202889 AF202890 AK292739 AK308047 AK315229
RefSeq transcript (Entrez)NM_001166598 NM_001371904 NM_052968
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)APOA5
Alternative Splicing GalleryENSG00000110243
Gene ExpressionAPOA5 [ NCBI-GEO ]   APOA5 [ EBI - ARRAY_EXPRESS ]   APOA5 [ SEEK ]   APOA5 [ MEM ]
Gene Expression Viewer (FireBrowse)APOA5 [ Firebrowse - Broad ]
GenevisibleExpression of APOA5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116519
GTEX Portal (Tissue expression)APOA5
Human Protein AtlasENSG00000110243-APOA5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6Q788   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6Q788  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6Q788
Splice isoforms : SwissVarQ6Q788
PhosPhoSitePlusQ6Q788
Domains : Interpro (EBI)ApoA_E   
Domain families : Pfam (Sanger)Apolipoprotein (PF01442)   
Domain families : Pfam (NCBI)pfam01442   
Conserved Domain (NCBI)APOA5
Blocks (Seattle)APOA5
SuperfamilyQ6Q788
Human Protein Atlas [tissue]ENSG00000110243-APOA5 [tissue]
Peptide AtlasQ6Q788
HPRD06966
IPIIPI00465378   IPI00657743   
Protein Interaction databases
DIP (DOE-UCLA)Q6Q788
IntAct (EBI)Q6Q788
BioGRIDAPOA5
STRING (EMBL)APOA5
ZODIACAPOA5
Ontologies - Pathways
QuickGOQ6Q788
Ontology : AmiGOphospholipid binding  phospholipid binding  extracellular region  extracellular region  extracellular space  early endosome  late endosome  endoplasmic reticulum lumen  Golgi apparatus  triglyceride metabolic process  triglyceride metabolic process  cholesterol biosynthetic process  lipid transport  enzyme activator activity  heparin binding  lipid binding  positive regulation of cholesterol esterification  positive regulation of triglyceride catabolic process  positive regulation of triglyceride catabolic process  positive regulation of very-low-density lipoprotein particle remodeling  cholesterol binding  regulation of lipid metabolic process  triglyceride catabolic process  enzyme binding  regulation of intestinal cholesterol absorption  phosphatidylcholine binding  phosphatidylcholine binding  cholesterol efflux  phospholipid efflux  very-low-density lipoprotein particle  low-density lipoprotein particle  high-density lipoprotein particle  high-density lipoprotein particle  very-low-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  lipase binding  lipoprotein metabolic process  tissue regeneration  chylomicron  chylomicron  cholesterol homeostasis  cholesterol homeostasis  post-translational protein modification  cellular protein metabolic process  positive regulation of fatty acid biosynthetic process  positive regulation of fatty acid biosynthetic process  phosphatidylcholine metabolic process  positive regulation of receptor-mediated endocytosis  low-density lipoprotein particle receptor binding  positive regulation of lipid catabolic process  positive regulation of lipoprotein lipase activity  positive regulation of lipoprotein lipase activity  acylglycerol homeostasis  acylglycerol homeostasis  phosphatidylcholine-sterol O-acyltransferase activator activity  lipase activator activity  lipoprotein lipase activator activity  lipoprotein particle receptor binding  triglyceride homeostasis  triglyceride homeostasis  triglyceride homeostasis  
Ontology : EGO-EBIphospholipid binding  phospholipid binding  extracellular region  extracellular region  extracellular space  early endosome  late endosome  endoplasmic reticulum lumen  Golgi apparatus  triglyceride metabolic process  triglyceride metabolic process  cholesterol biosynthetic process  lipid transport  enzyme activator activity  heparin binding  lipid binding  positive regulation of cholesterol esterification  positive regulation of triglyceride catabolic process  positive regulation of triglyceride catabolic process  positive regulation of very-low-density lipoprotein particle remodeling  cholesterol binding  regulation of lipid metabolic process  triglyceride catabolic process  enzyme binding  regulation of intestinal cholesterol absorption  phosphatidylcholine binding  phosphatidylcholine binding  cholesterol efflux  phospholipid efflux  very-low-density lipoprotein particle  low-density lipoprotein particle  high-density lipoprotein particle  high-density lipoprotein particle  very-low-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  lipase binding  lipoprotein metabolic process  tissue regeneration  chylomicron  chylomicron  cholesterol homeostasis  cholesterol homeostasis  post-translational protein modification  cellular protein metabolic process  positive regulation of fatty acid biosynthetic process  positive regulation of fatty acid biosynthetic process  phosphatidylcholine metabolic process  positive regulation of receptor-mediated endocytosis  low-density lipoprotein particle receptor binding  positive regulation of lipid catabolic process  positive regulation of lipoprotein lipase activity  positive regulation of lipoprotein lipase activity  acylglycerol homeostasis  acylglycerol homeostasis  phosphatidylcholine-sterol O-acyltransferase activator activity  lipase activator activity  lipoprotein lipase activator activity  lipoprotein particle receptor binding  triglyceride homeostasis  triglyceride homeostasis  triglyceride homeostasis  
NDEx NetworkAPOA5
Atlas of Cancer Signalling NetworkAPOA5
Wikipedia pathwaysAPOA5
Orthology - Evolution
OrthoDB116519
GeneTree (enSembl)ENSG00000110243
Phylogenetic Trees/Animal Genes : TreeFamAPOA5
HOGENOMQ6Q788
Homologs : HomoloGeneAPOA5
Homology/Alignments : Family Browser (UCSC)APOA5
Gene fusions - Rearrangements
Fusion : QuiverAPOA5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPOA5 [hg38]
dbVarAPOA5
ClinVarAPOA5
MonarchAPOA5
1000_GenomesAPOA5 
Exome Variant ServerAPOA5
GNOMAD BrowserENSG00000110243
Varsome BrowserAPOA5
Genomic Variants (DGV)APOA5 [DGVbeta]
DECIPHERAPOA5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAPOA5 
Mutations
ICGC Data PortalAPOA5 
TCGA Data PortalAPOA5 
Broad Tumor PortalAPOA5
OASIS PortalAPOA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPOA5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAPOA5
Mutations and Diseases : HGMDAPOA5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APOA5
DgiDB (Drug Gene Interaction Database)APOA5
DoCM (Curated mutations)APOA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APOA5 (select a term)
intoGenAPOA5
Cancer3DAPOA5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM144650    145750    606368   
Orphanet10944   
DisGeNETAPOA5
MedgenAPOA5
Genetic Testing Registry APOA5
NextProtQ6Q788 [Medical]
GENETestsAPOA5
Target ValidationAPOA5
Huge Navigator APOA5 [HugePedia]
ClinGenAPOA5
Clinical trials, drugs, therapy
MyCancerGenomeAPOA5
Protein Interactions : CTD
Pharm GKB GenePA24888
Clinical trialAPOA5
Miscellaneous
canSAR (ICR)APOA5 (select the gene name)
HarmonizomeAPOA5
DataMed IndexAPOA5
Probes
Litterature
PubMed425 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPOA5
EVEXAPOA5
GoPubMedAPOA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Dec 5 16:46:02 CET 2020
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