APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A)

2008-05-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
A3A,ARP3,PHRBN,bK150C2.1

Other Information

Locus ID:

NCBI: 200315
MIM: 607109
HGNC: 17343
Ensembl: ENSG00000128383

Variants:

dbSNP: 200315
ClinVar: 200315
TCGA: ENSG00000128383
COSMIC: APOBEC3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128383ENST00000249116P31941
ENSG00000128383ENST00000249116A0A0K0MJ49
ENSG00000128383ENST00000402255P31941
ENSG00000128383ENST00000402255A0A0K0MJ49
ENSG00000128383ENST00000618553P31941
ENSG00000128383ENST00000618553A0A0K0MJ49

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200620552010APOBEC3 proteins mediate the clearance of foreign DNA from human cells.164
235998962013DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.152
164073272006APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells.148
184037102008Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions.139
247282942014Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.122
262588492015An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.109
214607932011APOBEC3A can activate the DNA damage response and cause cell-cycle arrest.101
236956842013NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity.79
194618822009Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase.73
268324002016APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.66

Citation

Dessen P

APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50116/apobec3a