APOBEC3B (apolipoprotein B mRNA editing enzyme catalytic subunit 3B)

2008-05-01  

Identity

HGNC
APOBEC3B
LOCATION
22q13.1
LOCUSID
9582
ALIAS
A3B,APOBEC1L,ARCD3,ARP4,DJ742C19.2,PHRBNL,bK150C2.2

Other Information

Locus ID:

NCBI: 9582
MIM: 607110
HGNC: 17352
Ensembl: ENSG00000179750

Variants:

dbSNP: 9582
ClinVar: 9582
TCGA: ENSG00000179750
COSMIC: APOBEC3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179750ENST00000333467Q9UH17
ENSG00000179750ENST00000335760Q9UH17
ENSG00000179750ENST00000402182B0QYD3
ENSG00000179750ENST00000407298Q9UH17

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalVariantAnnotationassociatedPD30697902
PA443450AsthmaDiseaseVariantAnnotationassociatedPD30697902

References

Pubmed IDYearTitleCitations
233894452013APOBEC3B is an enzymatic source of mutation in breast cancer.321
238521682013Evidence for APOBEC3B mutagenesis in multiple human cancers.269
154668722004APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.159
235998962013DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.152
166481362006APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.150
164073272006APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells.148
184037102008Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions.139
247282942014Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.122
174478452007Population stratification of a common APOBEC gene deletion polymorphism.115
174478452007Population stratification of a common APOBEC gene deletion polymorphism.115

Citation

Dessen P

APOBEC3B (apolipoprotein B mRNA editing enzyme catalytic subunit 3B)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50120/apobec3b